Product References
Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C
16-0031-82 was used in T-Cell Activation to evaluate the combination of a DPP4 inhibitor (anagliptin) and PD-L1 blockade in an NSCLC mouse model.
Wed Nov 01 00:00:00 EDT 2023
Vaccination-based immunotherapy to target profibrotic cells in liver and lung.
Cell stem cell
Sobecki M,Chen J,Krzywinska E,Nagarajan S,Fan Z,Nelius E,Monné Rodriguez JM,Seehusen F,Hussein A,Moschini G,Hajam EY,Kiran R,Gotthardt D,Debbache J,Badoual C,Sato T,Isagawa T,Takeda N,Tanchot C,Tartour E,Weber A,Werner S,Loffing J,Sommer L,Sexl V,Münz C,Feghali-Bostwick C,Pachera E,Distler O,Snedeker J,Jamora C,Stockmann C
16-0031-82 was used in Flow Cytometry, Functional Assay, In Vitro Assay to demonstrate the efficacy of a vaccination approach to mount CD8+ T cell responses that reduce fibroblasts and fibrosis in the liver and lungs in mice.
Thu Oct 06 00:00:00 EDT 2022
Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.
Cell reports
Dunlock VE,Arp AB,Singh SP,Charrin S,Nguyen V,Jansen E,Schaper F,Beest MT,Zuidscherwoude M,van Deventer SJ,Nakken B,Szodoray P,Demaria MC,Wright MD,Querol Cano L,Rubinstein E,van Spriel AB
16-0031-82 was used in Flow Cytometry, Functional Assay, Western Blot to reveal CD53 as a regulator of CD45 activity required for T cell immunity.
Tue Jun 28 00:00:00 EDT 2022
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models.
Science translational medicine
Hajnik RL,Plante JA,Liang Y,Alameh MG,Tang J,Bonam SR,Zhong C,Adam A,Scharton D,Rafael GH,Liu Y,Hazell NC,Sun J,Soong L,Shi PY,Wang T,Walker DH,Sun J,Weissman D,Weaver SC,Plante KS,Hu H
16-0031-82 was used in ELISA to suggest that combined mRNA-S+N vaccination is an effective approach for promoting broad protection against SARS-CoV-2 variants.
Wed Sep 14 00:00:00 EDT 2022
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity.
Cellular & molecular immunology
Dumauthioz N,Tschumi B,Wenes M,Marti B,Wang H,Franco F,Li W,Lopez-Mejia IC,Fajas L,Ho PC,Donda A,Romero P,Zhang L
16-0031 was used in Western Blotting to indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation, metabolic fitness, and antitumor immunity in vivo.
Thu Jul 01 00:00:00 EDT 2021
SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses.
Journal of virology
Carnell GW,Ciazynska KA,Wells DA,Xiong X,Aguinam ET,McLaughlin SH,Mallery D,Ebrahimi S,Ceron-Gutierrez L,Asbach B,Einhauser S,Wagner R,James LC,Doffinger R,Heeney JL,Briggs JAG
16-0031-82 was used in ELISA to assess the use as an immunogen of a spike protein engineered to be conformationally stabilized in the closed state where the receptor binding site is occluded.
Mon Jul 12 00:00:00 EDT 2021
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Frontiers in cell and developmental biology
Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F
16-0031-81 was used in T-Cell Activation to show the phenomenon of brown adipose tissue 'whitening' in old mice, induced by IFN-γ secretion by senescent T cells.
Tue Mar 23 00:00:00 EDT 2021
The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine.
International journal of molecular sciences
Ergang P,Vagnerová K,Hermanová P,Vodička M,Jágr M,Šrůtková D,Dvořáček V,Hudcovic T,Pácha J
16-0031 was used in functional assays to investigate the influence of the microbiota on de novo steroidogenesis and regeneration of corticosterone in the intestine of germ-free (GF) and specific pathogen-free mice challenged with a physical stressor (anti-CD3 antibody i.p. injection).
Mon Apr 19 00:00:00 EDT 2021
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion.
Journal of experimental & clinical cancer research : CR
Fang W,Zhou T,Shi H,Yao M,Zhang D,Qian H,Zeng Q,Wang Y,Jin F,Chai C,Chen T
16-0031-82 was used in Functional assay to provide new ideas and targets for clinical breast cancer immunotherapy.
Mon Jan 04 00:00:00 EST 2021
Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.
Cancer immunology research
De Martino M,Daviaud C,Diamond JM,Kraynak J,Alard A,Formenti SC,Miller LD,Demaria S,Vanpouille-Box C
16-0031-82 was used in Flow Cytometry to shed light on an immune escape mechanism driven by activin A and suggest that dual targeting of activin A and TGFβ may be required to optimally unleash radiation-induced antitumor immunity against breast cancer.
Fri Jan 01 00:00:00 EST 2021
Generation of a chemical genetic model for JAK3.
Scientific reports
Remenyi J,Naik RJ,Wang J,Razsolkov M,Verano A,Cai Q,Tan L,Toth R,Raggett S,Baillie C,Traynor R,Hastie CJ,Gray NS,Arthur JSC
16-0031-82 was used in Functional assay to generate a JAK3 Cys905Ser knockin mouse demonstrating decreased ability of covalent JAK3 inhibitors to block JAK3 function.
Wed May 12 00:00:00 EDT 2021
PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity.
Frontiers in immunology
Amici SA,Osman W,Guerau-de-Arellano M
16-0031-82 was used in Flow Cytometry to demonstrate the role of protein arginine N-methyltransferase 5 in T cell activation during multiple sclerosis.
Mon Dec 13 00:00:00 EST 2021
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
16-0031-82 was used in Flow Cytometry to report a function of FATS in tumor development via regulation of tumor immunity.
Wed Jul 14 00:00:00 EDT 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
16-0031 was used in Functional assays to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 EDT 2020
Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.
Immunity
Wu J,Dobbs N,Yang K,Yan N
16-0031-82 was used in Flow Cytometry to investigate if mammalian stimulator of interferon genes possesses widespread IFN-independent activities that are important for restricting HSV-1 infection, tumor immune evasion and likely also adaptive immunity.
Tue Jul 14 00:00:00 EDT 2020
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Proceedings of the National Academy of Sciences of the United States of America
Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR
16-0031-81 was used in In vitro Assay to report that activation of regulatory CD8 T cells (CD8 Treg) that recognize the Qa-1 class Ib major histocompatibility complex (MHC), a mouse homolog of human leukocyte antigen-E (HLA-E), inhibits antibody-mediated immune rejection of heart allografts.
Tue Mar 17 00:00:00 EDT 2020
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.
Basic research in cardiology
Lubos N,van der Gaag S,Gerçek M,Kant S,Leube RE,Krusche CA
16-0031 was used in Immunohistochemistry to investigate if specific immune cell populations and chemokine expression profiles modulate inflammatory and repair processes throughout arrhythmogenic cardiomyopathy progression.
Fri Jun 12 00:00:00 EDT 2020
Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation.
Cell proliferation
Ma Y,Yang Q,Fan M,Zhang L,Gu Y,Jia W,Li Z,Wang F,Li YX,Wang J,Li R,Shao X,Wang YL
16-0031 was used in Flow cytometry/Cell sorting to study the TGF-β1 expression and distribution of regulatory T cells (Tregs) along the placental-maternal circulation route.
Fri May 01 00:00:00 EDT 2020
Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy.
Cancer immunology, immunotherapy : CII
Wachowska M,Stachura J,Tonecka K,Fidyt K,Braniewska A,Sas Z,Kotula I,Rygiel TP,Boon L,Golab J,Muchowicz A
16-0031-82 was used in Flow Cytometry to investigate the antitumor potential of photodynamic therapy combined with indoleamine 2,3-dioxygenase 1 inhibitor in the murine 4T1 and E0771 orthotopic breast cancer models.
Mon Jun 01 00:00:00 EDT 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
16-0031 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner.
Journal of neurochemistry
Trudler D,Levy-Barazany H,Nash Y,Samuel L,Sharon R,Frenkel D
16-0031-82 was used in Functional assay to investigate if alpha synuclein can affect CD4+ T-cell proliferation and activity.
Wed Jan 01 00:00:00 EST 2020
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Wang J,Zhang X,Liu P,Zhang X,Wang J,Zheng X,Wei L,Peng Q,Liu C,Yan Q,Shen S,Li X,Ma J
16-0031 was used in Flow cytometry/Cell sorting to report that S100A8 significantly induced PD-L1 expression in monocytes/macrophages but not in tumor cells.
Fri May 01 00:00:00 EDT 2020
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
16-0031-81 was used in T-Cell Activation to investigate the associations between Th2 differentiation and miR-1165b-3p in asthma as well as the possible mechanisms.
Tue Sep 01 00:00:00 EDT 2020
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Investigative ophthalmology & visual science
Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X
16-0031-82 was used in Flow Cytometry to investigate the role of thymic stromal lymphopoietin secreted by Aspergillus fumigatus–stimulated dendritic cells during the T helper 17 immune response.
Tue Dec 01 00:00:00 EST 2020
Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro.
Experimental hematology
He X,Dou A,Feng S,Roman-Rivera A,Hawkins C,Lawley L,Zhang J,Wunderlich M,Mizukawa B,Halene S,Patel A,Fang J
16-0031-81 was used in T-Cell Activation to examine the combined effect of LEN and Cys in MDS/AML cells and T cells.
Mon Jun 01 00:00:00 EDT 2020
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2.
BioMed research international
Zhao K,Tian Y,Wang J,Chen C,Pan B,Yan Z,Zhu S,Xu K
16-0031 was used in Western Blotting to conclude that administration of Fluvastatin to donor mice showed protective effects against recipient aGVHD when compared to untreated mice due to the retention of effector T cells in lymphoid organs accompanying with reduction of nonlymphatic infiltration and related inflammatory cytokines.
Fri Sep 10 00:00:00 EDT 2021
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.
Nature communications
Guo X,Pan Y,Xiong M,Sanapala S,Anastasaki C,Cobb O,Dahiya S,Gutmann DH
16-0031 was used in Immunohistochemistry-immunofluorescence to leverage genetically engineered mouse models and human biospecimens to define the axis in which neurons, T cells, and microglia interact to govern Neurofibromatosis-1 (NF1) low-grade glioma (LGG) growth.
Fri May 01 00:00:00 EDT 2020
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
16-0031 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 EDT 2020
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.
Cell reports
Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA
16-0031-82 was used in Functional assay to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.
Tue Feb 04 00:00:00 EST 2020
Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti-Lag-3 via reducing FGL1 expression.
Cancer medicine
Wang J,Wei W,Tang Q,Lu L,Luo Z,Li W,Lu Y,Pu J
16-0031 was used in Functional assays to investigate whether Oxysophocarpine can distinctly suppress hepatocellular carcinoma (HCC) cells and sensitize the immunotherapy of CD8+ T cells against HCC.
Thu Oct 01 00:00:00 EDT 2020
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells.
Cell reports
Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT
16-0031 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Tue Mar 10 00:00:00 EDT 2020
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
Journal for immunotherapy of cancer
Marshall LA,Marubayashi S,Jorapur A,Jacobson S,Zibinsky M,Robles O,Hu DX,Jackson JJ,Pookot D,Sanchez J,Brovarney M,Wadsworth A,Chian D,Wustrow D,Kassner PD,Cutler G,Wong B,Brockstedt DG,Talay O
16-0031 was used in Flow cytometry/Cell sorting to demonstrate that CCR4-dependent Treg recruitment into the tumor is an important tumor-extrinsic mechanism for immune resistance.
Sun Nov 01 00:00:00 EDT 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
16-0031 was used in Functional assays to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 EST 2020
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
16-0031 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 EDT 2019
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.
Nature cell biology
Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,Sreekumar A,Rosen JM,Zhang XH
16-0031 was used in Flow cytometry/Cell sorting to demonstrate diverse myeloid cell frequencies, functionality and potential roles in immunotherapies, and highlight the need to better understand the inter-patient heterogeneity of the myeloid compartment.
Sun Sep 01 00:00:00 EDT 2019
Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection.
Proceedings of the National Academy of Sciences of the United States of America
Zheng M,Li D,Zhao Z,Shytikov D,Xu Q,Jin X,Liang J,Lou J,Wu S,Wang L,Hu H,Zhou Y,Gao X,Lu L
16-0031 was used in Functional assays to reveal the cell survival is regulated by PP2A which has a crucial role in the progression of thymocyte development.
Tue Jun 18 00:00:00 EDT 2019
KCa3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats.
Journal of the American Heart Association
She G,Ren YJ,Wang Y,Hou MC,Wang HF,Gou W,Lai BC,Lei T,Du XJ,Deng XL
16-0031 was used in Flow cytometry/Cell sorting to evaluate the impact of the specific KCa3.1 channel blocker TRAM-34 on cardiac fibrosis.
Tue Jan 08 00:00:00 EST 2019
C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions.
Frontiers in immunology
Jimenez RV,Kuznetsova V,Connelly AN,Hel Z,Szalai AJ
16-0031-82 was used in Flow cytometry/Cell sorting to demonstrate that CRP dose-dependently increases the generation of MDSC from wild type mouse bone marrow progenitors and enhances MDSC production of intracellular reactive oxygen species (iROS).
Tue Nov 10 00:00:00 EST 2020
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
Nature communications
Racioppi L,Nelson ER,Huang W,Mukherjee D,Lawrence SA,Lento W,Masci AM,Jiao Y,Park S,York B,Liu Y,Baek AE,Drewry DH,Zuercher WJ,Bertani FR,Businaro L,Geradts J,Hall A,Means AR,Chao N,Chang CY,McDonnell DP
16-0031-82 was used in Flow Cytometry to find that calcium/calmodulin-dependent kinase kinase (CaMKK2) to be highly expressed within intratumoral myeloid cells in mouse models of breast cancer.
Tue Jun 04 00:00:00 EDT 2019
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.
Nature communications
Kang YH,Biswas A,Field M,Snapper SB
16-0031 was used in Flow cytometry/Cell sorting to reveal a critical perspective on JAK-STAT1 signalling that might apply to multiple inflammatory diseases.
Fri Feb 22 00:00:00 EST 2019
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
16-0031-82 was used in In vitro experiments to study the role of microRNA-210 in the immune imbalance of T lymphocyte subsets in psoriasis and suggest a potential therapeutic avenue.
Fri Jun 01 00:00:00 EDT 2018
Cross-Talk between Myeloid-Derived Suppressor Cells and Mast Cells Mediates Tumor-Specific Immunosuppression in Prostate Cancer.
Cancer immunology research
Jachetti E,Cancila V,Rigoni A,Bongiovanni L,Cappetti B,Belmonte B,Enriquez C,Casalini P,Ostano P,Frossi B,Sangaletti S,Chiodoni C,Chiorino G,Pucillo CE,Tripodo C,Colombo MP
16-0031 was used in in vitro experiments to suggest that CD40L–CD40 signaling may sustain immune suppression in those cancer patients characterized by accumulation of both mast cells and MDSCs.
Tue May 01 00:00:00 EDT 2018
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.
Glia
Villadiego J,Labrador-Garrido A,Franco JM,Leal-Lasarte M,De Genst EJ,Dobson CM,Pozo D,Toledo-Aral JJ,Roodveldt C
16-0031 was used in Functional assays to assess a novel vaccination strategy that uses a combination of α-Synuclein and Grp94 chaperone, and a murine Parkinson's disease model.
Mon Jan 01 00:00:00 EST 2018
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Majri SS,Fritz JM,Villarino AV,Zheng L,Kanellopoulou C,Chaigne-Delalande B,Grönholm J,Niemela JE,Afzali B,Biancalana M,Pittaluga S,Sun A,Cohen JL,Holland SM,O'Shea JJ,Uzel G,Lenardo MJ
16-0031 was used in Flow cytometry/Cell sorting to show that STAT5B, a transcription factor downstream of multiple cytokines involved in RICD, is essential for triggering apoptosis of mouse and human TEM cells, and that altered STAT5B transcriptional activity drives immunodeficiency and dysfunction.
Mon Jan 01 00:00:00 EST 2018
Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment.
Nature communications
Wunderlich CM,Ackermann PJ,Ostermann AL,Adams-Quack P,Vogt MC,Tran ML,Nikolajev A,Waisman A,Garbers C,Theurich S,Mauer J,Hövelmeyer N,Wunderlich FT
16-0031 was used in Immunohistochemistry to investigate whether obesity-induced inflammation predisposes to colorectal cancer development.
Wed Apr 25 00:00:00 EDT 2018
NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation.
Nature communications
Brosseau JP,Liao CP,Wang Y,Ramani V,Vandergriff T,Lee M,Patel A,Ariizumi K,Le LQ
16-0031 was used in Functional assays to study the role of the neurofibromatosis type 1 tumour suppressor gene in de novo tumorigenesis and malignant transformation.
Tue Nov 27 00:00:00 EST 2018
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Cell metabolism
Ma EH,Bantug G,Griss T,Condotta S,Johnson RM,Samborska B,Mainolfi N,Suri V,Guak H,Balmer ML,Verway MJ,Raissi TC,Tsui H,Boukhaled G,Henriques da Costa S,Frezza C,Krawczyk CM,Friedman A,Manfredi M,Richer MJ,Hess C,Jones RG
16-0031 was used in Flow cytometry/Cell sorting to show adaptive immunity is directly modulated by serine through the control of T cell proliferative capacity.
Tue Feb 07 00:00:00 EST 2017
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Cell metabolism
Liberti MV,Dai Z,Wardell SE,Baccile JA,Liu X,Gao X,Baldi R,Mehrmohamadi M,Johnson MO,Madhukar NS,Shestov AA,Chio IIC,Elemento O,Rathmell JC,Schroeder FC,McDonnell DP,Locasale JW
16-0031 was used in Functional assays to develop a predictive model for selective targeting of the Warburg effect.
Tue Oct 03 00:00:00 EDT 2017
Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Orillion A,Hashimoto A,Damayanti N,Shen L,Adelaiye-Ogala R,Arisa S,Chintala S,Ordentlich P,Kao C,Elzey B,Gabrilovich D,Pili R
16-0031 was used in Flow cytometry/Cell sorting to study whether entinostat can enhance anti-PD-1 treatment, and investigate those alterations in the immunosuppressive tumour microenvironment that contribute to the combined anti-tumour activity.
Fri Sep 01 00:00:00 EDT 2017
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Cancer immunology research
Kubo H,Mensurado S,Gonçalves-Sousa N,Serre K,Silva-Santos B
16-0031 was used in Flow cytometry/Cell sorting to identifies an innate cell network and the molecular determinants responsible for metastasis immunosurveillance, providing support for using the key molecular mediator to improve immunotherapeutic outcomes.
Fri Sep 01 00:00:00 EDT 2017
NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.
European journal of immunology
Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S
16-0031 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.
Fri Sep 01 00:00:00 EDT 2017
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase.
Chinese medicine
Houng JY,Tai TS,Hsu SC,Hsu HF,Hwang TS,Lin CJ,Fang LW
16-0031 was used in Functional assays to study how anti-inflammatory effects exerted by GTE are mediated via suppression of JNK phosphorylation in T cell activation.
Wed Sep 30 00:00:00 EDT 2020
Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor.
Mediators of inflammation
Zhao GJ,Zheng JY,Bian JL,Chen LW,Dong N,Yu Y,Hong GL,Chandoo A,Yao YM,Lu ZQ
16-0031 was used in Flow cytometry/Cell sorting to investigate the role of the TAM ligand, growth arrest-specific 6, as an immune modulator.
Mon Jul 10 00:00:00 EDT 2017
A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments.
Mediators of inflammation
Jia B,Zhao C,Li G,Kong Y,Ma Y,Wang Q,Wang B,Zeng H
16-0031 was used in Flow cytometry/Cell sorting to develop a novel strategy for distinguishing granulocytic myeloid-derived suppressor cells from monocytic MDSCs in septic mice by expression of CD48.
Mon Aug 14 00:00:00 EDT 2017
SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance.
Molecular pharmacology
Li J,Jing J,Bai Y,Li Z,Xing R,Tan B,Ma X,Qiu WW,Du C,Du B,Yang F,Tang J,Siwko S,Liu M,Chen H,Luo J
16-0031 was used in Functional assays to identify a betulinic acid derivative, SH479, able to modulate the Th17/Treg balance to ameliorate experimental autoimmune encephalomyelitis.
Mon May 01 00:00:00 EDT 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
16-0031-82 was used in Flow Cytometry to demonstrate that BM‚derived DC culture systems were heterogeneous, comprising of non‚adherent cells, adherent cells, mixed cells and firmly adherent cells.
Wed Nov 01 00:00:00 EDT 2017
T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab.
PloS one
Bughani U,Saha A,Kuriakose A,Nair R,Sadashivarao RB,Venkataraman R,Patel S,Deshchougule AT,S SK,Montero E,Pai HV,Palanivelu DV,Melarkode R,Nair P
16-0031 was used in Functional assays to investigate the effect of Itolizumab on T cels.
Fri Oct 06 00:00:00 EDT 2017
Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.
Scientific reports
Wang H,Mo L,Xiao X,An S,Liu X,Ba J,Wu W,Ran P,Yang P,Liu Z
16-0031 was used in an ELISA assay to demonstrate that Pplase is not a dustmite allergen but can enhance allergic responses.
Mon Feb 27 00:00:00 EST 2017
Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts.
Oncotarget
Zhang S,Al-Maghout T,Bissinger R,Zeng N,Pelzl L,Salker MS,Cheng A,Singh Y,Lang F
16-0031 was used in Functional assays to suggest that epigallocatechin-3-gallate inhibits the Ca2+ entry into murine and human T cells.
Fri Oct 27 00:00:00 EDT 2017
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
Nature
Xu T,Stewart KM,Wang X,Liu K,Xie M,Ryu JK,Li K,Ma T,Wang H,Ni L,Zhu S,Cao N,Zhu D,Zhang Y,Akassoglou K,Dong C,Driggers EM,Ding S
16-0031-82 was used in Immunohistochemistry, Flow Cytometry, Functional Assay to investigate T helper 17 cell differentiation and fate.
Thu Aug 10 00:00:00 EDT 2017
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
16-0031-82 was used in T-Cell Activation to show that therapeutic vaccination against DLK1 results in slowed tumor growth, and compensatory expression of DLK2 by tumor-associated pericytes.
Tue Jan 12 00:00:00 EST 2021
A Mouse Model of West Nile Virus Infection.
Current protocols in mouse biology
Graham JB,Swarts JL,Lund JM
16-0031 was used in Functional assays to develop a mouse model to study the breadth of symptoms and disease severity seen in human West Nile virus infection.
Wed Dec 20 00:00:00 EST 2017
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nature communications
Yamamura K,Uruno T,Shiraishi A,Tanaka Y,Ushijima M,Nakahara T,Watanabe M,Kido-Nakahara M,Tsuge I,Furue M,Fukui Y
16-0031 was used in Flow cytometry/Cell sorting to reveal how transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4+ T cells.
Mon Jan 09 00:00:00 EST 2017
Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.
Scientific reports
Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z
16-0031 was used in Flow cytometry/Cell sorting to investigate whether Dermatophagoides farinae-31 modulates airway epithelial cell functions, and increases the frequency of lung-resident group 2 innate lymphoid cells.
Thu Aug 17 00:00:00 EDT 2017
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
16003182 was used in blocking or activating experiment to elucidate the role of TfR1 in adaptive immunity
Fri Jan 01 00:00:00 EST 2016
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Nature immunology
Martin BN,Wang C,Zhang CJ,Kang Z,Gulen MF,Zepp JA,Zhao J,Bian G,Do JS,Min B,Pavicic PG,El-Sanadi C,Fox PL,Akitsu A,Iwakura Y,Sarkar A,Wewers MD,Kaiser WJ,Mocarski ES,Rothenberg ME,Hise AG,Dubyak GR,Ransohoff RM,Li X
16-0031 was used in Functional assays to reveal a critical role for IL-1β produced by a T(H)17 cell-intrinsic ASC-NLRP3-caspase-8 inflammasome during inflammation of the central nervous system.
Sun May 01 00:00:00 EDT 2016
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Nature cell biology
Welte T,Kim IS,Tian L,Gao X,Wang H,Li J,Holdman XB,Herschkowitz JI,Pond A,Xie G,Kurley S,Nguyen T,Liao L,Dobrolecki LE,Pang L,Mo Q,Edwards DP,Huang S,Xin L,Xu J,Li Y,Lewis MT,Wang T,Westbrook TF,Rosen JM,Zhang XH
16003182 was used in blocking or activating experiment to describe the role of mTOR signalling in recruiting pro-tumorigenic myeloid-derived suppressor cells.
Wed Jun 01 00:00:00 EDT 2016
Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice.
Cellular & molecular immunology
Jiang Y,Gao Q,Wang L,Guo C,Zhu F,Wang B,Wang Q,Gao F,Chen Y,Zhang L
16-0031 was used in Flow cytometry/Cell sorting to investigate the role of programmed cell death 4 in atherosclerosis.
Fri Jul 01 00:00:00 EDT 2016
Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites.
The Journal of experimental medicine
Demarta-Gatsi C,Smith L,Thiberge S,Peronet R,Commere PH,Matondo M,Apetoh L,Bruhns P,Ménard R,Mécheri S
16-0031 was used in Flow cytometry/Cell sorting to identify a novel blood stage genetically attenuated parasite that lacks a secreted factor and assess immune responses to this.
Mon Jul 25 00:00:00 EDT 2016
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
The Journal of experimental medicine
Hu H,Wang H,Xiao Y,Jin J,Chang JH,Zou Q,Xie X,Cheng X,Sun SC
16-0031 was used in Immunoprecipitation to reveal the importance of deubiquitination in regulating Zap70 function.
Mon Mar 07 00:00:00 EST 2016
The Antitumor Efficacy of IL2/IL21-Cultured Polyfunctional Neu-Specific T Cells Is TNFα/IL17 Dependent.
Clinical cancer research : an official journal of the American Association for Cancer Research
Phan-Lai V,Dang Y,Gad E,Childs J,Disis ML
16-0031 was used in an ELISpot assay to investigate whether alteration of cytokine growth factors used to culture vaccine-primed T cells could improve antitumour activity.
Sun May 01 00:00:00 EDT 2016
ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings.
Science signaling
Weiss JM,Chen W,Nyuydzefe MS,Trzeciak A,Flynn R,Tonra JR,Marusic S,Blazar BR,Waksal SD,Zanin-Zhorov A
16-0031 was used in Functional assays to investigate the role of Rho-associated kinase 2 in the generation of T follicular helper cells.
Tue Jul 19 00:00:00 EDT 2016
ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings.
Science signaling
Weiss JM,Chen W,Nyuydzefe MS,Trzeciak A,Flynn R,Tonra JR,Marusic S,Blazar BR,Waksal SD,Zanin-Zhorov A
16-0031 was used in Functional assays to investigate the role of Rho-associated kinase 2 in the generation of T follicular helper cells.
Tue Jul 19 00:00:00 EDT 2016
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
PLoS pathogens
Kandasamy M,Suryawanshi A,Tundup S,Perez JT,Schmolke M,Manicassamy S,Manicassamy B
16-0031 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid inducible gene-I in antiviral host responses.
Fri Jul 01 00:00:00 EDT 2016
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels.
Journal of immunology (Baltimore, Md. : 1950)
Rota G,Ludigs K,Siegert S,Tardivel A,Morgado L,Reith W,De Gassart A,Guarda G
16-0031 was used in Flow cytometry/Cell sorting to show that Nlrc5 deficiency is not sufficient to hinder T cell activation, highlighting the robustness of the T cell priming process by activated dendritic cells.
Fri Apr 01 00:00:00 EDT 2016
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Poczobutt JM,Nguyen TT,Hanson D,Li H,Sippel TR,Weiser-Evans MC,Gijon M,Murphy RC,Nemenoff RA
16-0031 was used in Flow cytometry/Cell sorting to reveal an antitumorigenic role for 5-LO products in the microenvironment during lung cancer progression through T cell regulation.
Fri Jan 15 00:00:00 EST 2016
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.
Scientific reports
Luu TT,Ganesan S,Wagner AK,Sarhan D,Meinke S,Garbi N,Hämmerling G,Alici E,Kärre K,Chambers BJ,Höglund P,Kadri N
16-0031 was used in Flow cytometry/Cell sorting to study the effect of DC depletion on resting NK cell function.
Thu Dec 01 00:00:00 EST 2016
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nature communications
Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS
16-0031 was used in Flow cytometry/Cell sorting to studying Treg cell engagement with the lymphotoxin beta receptor in transendothelial migration.
Tue Jun 21 00:00:00 EDT 2016
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.
Nature communications
Tosiek MJ,Fiette L,El Daker S,Eberl G,Freitas AA
16-0031 was used in an ELISA assay to demonstrate that impaired delivery of IL-15 to CD4+ T cells in the colon down-modulates Foxp3 expression and enhances RORγt expression.
Fri Mar 11 00:00:00 EST 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
16-0031 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 EDT 2016
Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses.
Scientific reports
Li Y,Wang H,Zhou X,Xie X,Chen X,Jie Z,Zou Q,Hu H,Zhu L,Cheng X,Brightbill HD,Wu LC,Wang L,Sun SC
16-0031 was used in Flow cytometry/Cell sorting to demonstrate a role for NF-κB inducing kinase in regulating the homeostasis and function of peripheral T cells.
Thu Feb 25 00:00:00 EST 2016
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production.
Scientific reports
Oh JE,Lee MS,Kim YJ,Lee HK
16-0031 was used in Flow cytometry/Cell sorting to investigate the role of 2'-5' oligoadenylate synthetase-like 1 (OASL1) during localised viral infection in mice.
Mon Jan 11 00:00:00 EST 2016
CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma.
Oncoimmunology
Bagchi S,Li S,Wang CR
16-0031 was used in Functional assays to demonstrate the antitumor potential of CD1b-autoreactive T cells and their potential use in adoptive immunotherapy.
Tue Jan 12 00:00:00 EST 2021
Encephalitozoon intestinalis Inhibits Dendritic Cell Differentiation through an IL-6-Dependent Mechanism.
Frontiers in cellular and infection microbiology
Bernal CE,Zorro MM,Sierra J,Gilchrist K,Botero JH,Baena A,Ramirez-Pineda JR
16-0031 was used in Flow cytometry/Cell sorting to investigate the in vitro response of dendritic cells and their precursors/progenitors to infection with Encephalitozoon intestinalis.
Fri Nov 11 00:00:00 EST 2016
Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Is Transfer Dose-Dependent.
PloS one
Morabito KM,Erez N,Graham BS,Ruckwardt TJ
16-0031 was used in Flow cytometry/Cell sorting to compare the immune response to respiratory syncytial virus infection following adoptive transfer of two transgenic CD8+ T cell lines.
Tue Jul 19 00:00:00 EDT 2016
Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
PloS one
Momose F,Seo N,Akahori Y,Sawada S,Harada N,Ogura T,Akiyoshi K,Shiku H
16-0031 was used in Flow cytometry/Cell sorting to statistically analyse miRNA microarray data, revealing that guanine-rich sequences are a dominant feature of exosome-dominant miRNAs.
Wed Apr 05 00:00:00 EDT 2017
PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes.
Immunoendocrinology (Houston, Tex.)
Martinov T,Spanier JA,Pauken KE,Fife BT
16-0031 was used in Flow cytometry/Cell sorting to understand the role of PD-1 in maintaining islet-specific tolerance in diabetes-resistant strains.
Wed Mar 30 00:00:00 EDT 2022
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
16-0031 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 EST 2015
Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.
The Journal of experimental medicine
Ruppert R,Moser M,Sperandio M,Rognoni E,Orban M,Liu WH,Schulz AS,Oostendorp RA,Massberg S,Fässler R
16-0031 was used in Flow cytometry/Cell sorting to highlight a role for Kindlin-3 in the control of haematopoietic stem and progenitor cell homing function.
Mon Aug 24 00:00:00 EDT 2015
Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation.
Autophagy
Botbol Y,Patel B,Macian F
16-0031 was used in Functional assays to identify the signalling pathways that initiate and regulate macroautophagy in T cells.
Tue Sep 13 00:00:00 EDT 2016
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.
eLife
Kumari S,Depoil D,Martinelli R,Judokusumo E,Carmona G,Gertler FB,Kam LC,Carman CV,Burkhardt JK,Irvine DJ,Dustin ML
16-0031 was used in Functional assays to assess the contribution of WASP to the architecture of the immunological synapse and to optimal immune responses.
Wed Mar 11 00:00:00 EDT 2015
Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Römer C,Engel O,Winek K,Hochmeister S,Zhang T,Royl G,Klehmet J,Dirnagl U,Meisel C,Meisel A
16-0031 was used in Immunohistochemistry to show that inhibiting stroke-induced immunodepression by pharmacological blockade of body's stress axes increases autoreactive CNS antigen-specific T-cell responses in the brain.
Wed May 20 00:00:00 EDT 2015
Late administration of murine CTLA-4 blockade prolongs CD8-mediated anti-tumor effects following stimulatory cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Sckisel GD,Mirsoian A,Bouchlaka MN,Tietze JK,Chen M,Blazar BR,Murphy WJ
16-0031 was used in Functional assays to investigate whether blockade of negative regulators such as CTLA-4 could simultaneously prolong CD8(+) T cell responses and augment T cell anti-tumour effects.
Tue Dec 01 00:00:00 EST 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
16-0031 was used in Flow cytometry/Cell sorting to identify a novel leukocyte receptor, TARM1, and investigate the mechanisms underlying its proinflammatory effects.
Thu Oct 01 00:00:00 EDT 2015
Newly recruited CD11b+, GR-1+, Ly6C(high) myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus.
Journal of immunology (Baltimore, Md. : 1950)
Clements DR,Sterea AM,Kim Y,Helson E,Dean CA,Nunokawa A,Coyle KM,Sharif T,Marcato P,Gujar SA,Lee PW
16-0031 was used in Functional assays to demonstrate that reovirus augments tumour-associated immunosuppression immediately following its therapeutic administration.
Fri May 01 00:00:00 EDT 2015
Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.
Journal of immunology (Baltimore, Md. : 1950)
Ackermann JA,Nys J,Schweighoffer E,McCleary S,Smithers N,Tybulewicz VL
16-0031 was used in Flow cytometry/Cell sorting to define the contribution of Syk to B cell function.
Fri May 15 00:00:00 EDT 2015
Role of CD4+ Foxp3+ Regulatory T Cells in Protection Induced by a Live Attenuated, Replicating Type I Vaccine Strain of Toxoplasma gondii.
Infection and immunity
Akbar H,Dimier-Poisson I,Moiré N
16-0031 was used in Functional assays to investigate the involvement of Tregs in the protection against Toxoplasma gondii type I and type II strains following vaccination with the live attenuated Mic1.3KO strain.
Tue Sep 01 00:00:00 EDT 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
16-0031 was used in Functional assays to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
Treatment with incomplete Freund's adjuvant and Listeria monocytogenes delays diabetes via an interleukin-17-secretion-independent pathway.
Experimental and therapeutic medicine
Wang HP,He ZG
16-0031 was used in Flow cytometry/Cell sorting to examine the effect of incomplete Freund''s adjuvant and L. monocytogenes treatment on the development of type I diabetes in non-obese diabetes mice.
Fri May 01 00:00:00 EDT 2015
All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β.
BMC immunology
Wang X,Wang W,Xu J,Wu S,Le Q
16-0031 was used in Flow cytometry/Cell sorting to investigate the potential effect of the application of ATRA and TGF-β on immunological tolerance and the treatment of posttransplant rejection.
Thu Mar 19 00:00:00 EDT 2015
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.
Stem cell reports
Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L
16-0031 was used in Flow cytometry/Cell sorting to elucidate the molecules and mechanisms pertinent to the low immunogenicity of undifferentiated embryonic stem cells.
Tue Nov 10 00:00:00 EST 2015
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.
Genome biology
Nestor CE,Ottaviano R,Reinhardt D,Cruickshanks HA,Mjoseng HK,McPherson RC,Lentini A,Thomson JP,Dunican DS,Pennings S,Anderton SM,Benson M,Meehan RR
16-0031 was used in Magnetic cell separation to report a dramatic and novel consequence of adaptation of mammalian cells to culture in which global loss of 5hmC occurs, suggesting rapid concomitant loss of methylcytosine dioxygenase activity.
Wed Feb 04 00:00:00 EST 2015
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis.
Nature communications
Pan W,Zhu S,Dai D,Liu Z,Li D,Li B,Gagliani N,Zheng Y,Tang Y,Weirauch MT,Chen X,Zhu W,Wang Y,Chen B,Qian Y,Chen Y,Fang J,Herbst R,Richman L,Jallal B,Harley JB,Flavell RA,Yao Y,Shen N
16-0031 was used in Functional assays to suggest miR-125a as a critical factor in controlling autoimmune diseases through stabilizing Treg-mediated immune homeostasis.
Tue May 12 00:00:00 EDT 2015
Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.
Scientific reports
Franken L,Klein M,Spasova M,Elsukova A,Wiedwald U,Welz M,Knolle P,Farle M,Limmer A,Kurts C
16-0031 was used in Flow cytometry/Cell sorting to elucidate the intrinsic superparamagnetic nature of splenic red pulp macrophages and their effect on magnetic cell isolates.
Tue Aug 11 00:00:00 EDT 2015
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.
The Journal of experimental medicine
Farin HF,Karthaus WR,Kujala P,Rakhshandehroo M,Schwank G,Vries RG,Kalkhoven E,Nieuwenhuis EE,Clevers H
16-0031 was used in Functional assays to study the control of paneth cell degranulation in primary epithelial organoids in culture, showing that it is directly controlled by immune cell-derived IFN-γ.
Mon Jun 30 00:00:00 EDT 2014
microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells.
The Journal of experimental medicine
Marcais A,Blevins R,Graumann J,Feytout A,Dharmalingam G,Carroll T,Amado IF,Bruno L,Lee K,Walzer T,Mann M,Freitas AA,Boothby M,Fisher AG,Merkenschlager M
16-0031 was used in Functional assays to investigate whether microRNAs affect the interpretation of TCR signalling.
Mon Oct 20 00:00:00 EDT 2014
Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.
Journal of autoimmunity
Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S
16-0031 was used in Functional assays to determine how different invariant natural killer T cell subsets contribute to lupus pathogenesis.
Thu May 01 00:00:00 EDT 2014
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
EMBO molecular medicine
Bilbao D,Luciani L,Johannesson B,Piszczek A,Rosenthal N
16-0031 was used in Functional assays to investigate the use of human insulin-like growth factor-1 to treat type 1 diabetes and multiple sclerosis.
Sat Nov 01 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
16-0031 was used in Flow cytometry/Cell sorting to study regulation of the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis during autophagy.
Tue Jul 01 00:00:00 EDT 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
16-0031 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 EDT 2014
Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit.
Molecular therapy : the journal of the American Society of Gene Therapy
Wang B,Zhuang X,Deng ZB,Jiang H,Mu J,Wang Q,Xiang X,Guo H,Zhang L,Dryden G,Yan J,Miller D,Zhang HG
16-0031 was used in Flow cytometry/Cell sorting to investigate whether nanovesicles released from edible fruit work with gut immune cells to maintain the gut in a noninflammatory status, showing that grapefruit-derived nanovesicles are selectively taken up by intestinal macrophages and can be used for targeted drug delivery.
Sat Mar 01 00:00:00 EST 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
16-0031 was used in Functional assays to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 EDT 2014
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.
Cancer immunology research
Ohkuri T,Ghosh A,Kosaka A,Zhu J,Ikeura M,David M,Watkins SC,Sarkar SN,Okada H
16-0031 was used in Flow cytometry/Cell sorting to display a potential use of STING agonists for the development of effective immunotherapy.
Mon Dec 01 00:00:00 EST 2014
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.
Cancer immunology research
Ohkuri T,Ghosh A,Kosaka A,Zhu J,Ikeura M,David M,Watkins SC,Sarkar SN,Okada H
16-0031 was used in Flow cytometry/Cell sorting to display a potential use of STING agonists for the development of effective immunotherapy.
Mon Dec 01 00:00:00 EST 2014
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
16-0031 was used in Functional assays to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K
16-0031 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.
Sat Mar 15 00:00:00 EDT 2014
IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection.
Journal of immunology (Baltimore, Md. : 1950)
Ahlfors H,Morrison PJ,Duarte JH,Li Y,Biro J,Tolaini M,Di Meglio P,Potocnik AJ,Stockinger B
16-0031 was used in Flow cytometry/Cell sorting to identify, trace and investigate IL-22-producing cells in vivo.
Sat Nov 01 00:00:00 EDT 2014
The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.
Journal of immunology (Baltimore, Md. : 1950)
Ehrlich A,Castilho TM,Goldsmith-Pestana K,Chae WJ,Bothwell AL,Sparwasser T,McMahon-Pratt D
16-0031 was used in Functional assays to investigate the role of Tregs in Leishmania disease pathogenesis.
Mon Sep 15 00:00:00 EDT 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
16-0031 was used in Flow cytometry/Cell sorting to investigate the importance of GM-CSF in the development of severe interstitial lung disease.
Tue Jul 15 00:00:00 EDT 2014
Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression.
Journal of immunology (Baltimore, Md. : 1950)
Boomer JS,Deppong CM,Shah DD,Bricker TL,Green JM
16-0031 was used in Functional assays to examine the phenotype of mice in which both the CD28 distal proline motif and the PI3K-binding motif are mutated.
Tue Apr 15 00:00:00 EDT 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
16-0031 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells.
Carcinogenesis
Rizzo A,De Mare V,Rocchi C,Stolfi C,Colantoni A,Neurath MF,Macdonald TT,Pallone F,Monteleone G,Fantini MC
16-0031 was used in in vitro experiments to investigate the potential influence of Smad7 on colorectal cancer growth and which immune cell subsets might be involved.
Tue Jul 01 00:00:00 EDT 2014
Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes.
PloS one
Qian L,Zhang M,Wu S,Zhong Y,Van Tol E,Cai W
16-0031 was used in Functional assays to demonstrate that AKGs can modulate immune responses by boosting the proliferation and maturation of murine lymphocytes in vitro.
Fri Jul 31 00:00:00 EDT 2015
C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.
PloS one
Norrie IC,Ohlsson E,Nielsen O,Hasemann MS,Porse BT
16-0031 was used in Flow cytometry/Cell sorting to investigate the potential of the transcription factor C/EBPα as a target for the alleviation of ageing/cancer-associated immunosenescence.
Tue Sep 16 00:00:00 EDT 2014
Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.
mBio
Prados-Rosales R,Carreño LJ,Batista-Gonzalez A,Baena A,Venkataswamy MM,Xu J,Yu X,Wallstrom G,Magee DM,LaBaer J,Achkar JM,Jacobs WR,Chan J,Porcelli SA,Casadevall A
16-0031 was used in Flow cytometry/Cell sorting to compare the effects of immunisation with membrane vesicles to those of the standard Bacillus Calmette-Guerin vaccination.
Tue Sep 30 00:00:00 EDT 2014
Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.
eLife
Sojka DK,Plougastel-Douglas B,Yang L,Pak-Wittel MA,Artyomov MN,Ivanova Y,Zhong C,Chase JM,Rothman PB,Yu J,Riley JK,Zhu J,Tian Z,Yokoyama WM
16-0031 was used in Flow cytometry/Cell sorting to investigate whether tissue-resident and cells resembling conventional splenic natural killer cells natural killer cells are derived from the same lineage, showing that there are at least four distinct lineages.
Wed Jan 01 00:00:00 EST 2014
Antitumor immunity induced after α irradiation.
Neoplasia (New York, N.Y.)
Gorin JB,Ménager J,Gouard S,Maurel C,Guilloux Y,Faivre-Chauvet A,Morgenstern A,Bruchertseifer F,Chérel M,Davodeau F,Gaschet J
16-0031 was used in in vitro experiments to determine that α irradiation is an immunogenic cell death inducer.
Tue Apr 01 00:00:00 EDT 2014
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.
Nature medicine
Gay D,Kwon O,Zhang Z,Spata M,Plikus MV,Holler PD,Ito M,Yang Z,Treffeisen E,Kim CD,Nace A,Zhang X,Baratono S,Wang F,Ornitz DM,Millar SE,Cotsarelis G
16-0031 was used in Immunofluorescence on frozen tissues to investigate the molecular mechanisms for regeneration of hair follicles.
Mon Jul 01 00:00:00 EDT 2013
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.
Nature medicine
Gay D,Kwon O,Zhang Z,Spata M,Plikus MV,Holler PD,Ito M,Yang Z,Treffeisen E,Kim CD,Nace A,Zhang X,Baratono S,Wang F,Ornitz DM,Millar SE,Cotsarelis G
16-0031 was used in Immunofluorescence on frozen tissues to investigate the molecular mechanisms for regeneration of hair follicles.
Mon Jul 01 00:00:00 EDT 2013
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Cancer cell
Engels B,Engelhard VH,Sidney J,Sette A,Binder DC,Liu RB,Kranz DM,Meredith SC,Rowley DA,Schreiber H
16-0031 was used in Functional assays to investigate relapse after adoptive therapy, showing that relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Mon Apr 15 00:00:00 EDT 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
16-0031 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2.
Blood
Jessen B,Bode SF,Ammann S,Chakravorty S,Davies G,Diestelhorst J,Frei-Jones M,Gahl WA,Gochuico BR,Griese M,Griffiths G,Janka G,Klein C,Kögl T,Kurnik K,Lehmberg K,Maul-Pavicic A,Mumford AD,Pace D,Parvaneh N,Rezaei N,de Saint Basile G,Schmitt-Graeff A,Schwarz K,Karasu GT,Zieger B,Zur Stadt U,Aichele P,Ehl S
16-0031 was used in Flow cytometry/Cell sorting to elucidate the risk of predisposition to certain disorders of lymphocyte cytotoxicity.
Thu Apr 11 00:00:00 EDT 2013
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells.
The Journal of experimental medicine
Kwan WH,van der Touw W,Paz-Artal E,Li MO,Heeger PS
16-0031 was used in Western Blotting to determine the mechanisms controlling natural regulatory T cell expansion.
Mon Feb 11 00:00:00 EST 2013
Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy.
Cancer gene therapy
Kanagawa N,Yanagawa T,Nakagawa T,Okada N,Nakagawa S
16-0031 was used in Functional assays to develop an immune-based antiangiogenic strategy against VEGFR2-expressing cells, improving antitumor effect of cytotoxic T lymphocytes.
Tue Jan 01 00:00:00 EST 2013
β-Arrestin-1 deficiency protects mice from experimental colitis.
The American journal of pathology
Lee T,Lee E,Irwin R,Lucas PC,McCabe LR,Parameswaran N
16-0031 was used in Flow cytometry/Cell sorting to demonstrate that altered interleukin production in β-arrestin-1-deficient mice likely leads to attenuated gut inflammation.
Mon Apr 01 00:00:00 EDT 2013
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.
Journal of immunology (Baltimore, Md. : 1950)
Kearl TJ,Jing W,Gershan JA,Johnson BD
16-0031 was used in Flow cytometry/Cell sorting to demonstrate that a blockade of the PD-1/PD-L1 pathway yields positive antitumour results.
Sat Jun 01 00:00:00 EDT 2013
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER
16-0031 was used in Flow cytometry/Cell sorting to demonstrate how CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
Tue Jan 15 00:00:00 EST 2013
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model.
Oncology reports
Kee JY,Ito A,Hojo S,Hashimoto I,Igarashi Y,Tsukada K,Irimura T,Shibahara N,Nakayama T,Yoshie O,Sakurai H,Saiki I,Koizumi K
16-0031 was used in Flow cytometry/Cell sorting to investigate the role of cancer-derived CXCL16 and the possibility of gene therapy using CXCL16 for the treatment of cancer.
Fri Mar 01 00:00:00 EST 2013
In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells.
PloS one
Davidson MG,Alonso MN,Kenkel JA,Suhoski MM,González JC,Yuan R,Engleman EG
16-0031 was used in Functional assays to investigate the effect of activated T cells on dendritic cell maturation, showing that activated T cells drive the rapid formation of CD209(+)CD11b(+)CD11c(+) MHC II(+) dendritic cells from monocytic precursors, with CD209(+) dendritic cells being able to stimulate T cell proliferation, but not polarisation like CD209(-) can.
Mon Jul 28 00:00:00 EDT 2014
Effects of Helicobacter suis γ-glutamyl transpeptidase on lymphocytes: modulation by glutamine and glutathione supplementation and outer membrane vesicles as a putative delivery route of the enzyme.
PloS one
Zhang G,Ducatelle R,Pasmans F,D'Herde K,Huang L,Smet A,Haesebrouck F,Flahou B
16-0031 was used in Functional assays to describe the effect of GGT from H. suis on various lymphocytes, showing that GGT leads to impaired proliferation and cell death in Jurkat T cells, CD4(+) T cells, CD8(+) T cells, and CD19(+) B cells; and that glutamine could restore proliferation.
Thu Jun 05 00:00:00 EDT 2014
Foxp3+ regulatory T cells are required for recovery from severe sepsis.
PloS one
Kühlhorn F,Rath M,Schmoeckel K,Cziupka K,Nguyen HH,Hildebrandt P,Hünig T,Sparwasser T,Huehn J,Pötschke C,Bröker BM
16-0031 was used in Flow cytometry/Cell sorting to determine the sufficiency of the suppressive capacity of Tregs for controlling inflammation due to sepsis.
Fri Jan 10 00:00:00 EST 2014
New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation.
PloS one
Morgan ME,Zheng B,Koelink PJ,van de Kant HJ,Haazen LC,van Roest M,Garssen J,Folkerts G,Kraneveld AD
16-0031 was used in Flow cytometry/Cell sorting to investigate the specificity of the immune cell response to colitis.
Wed Mar 05 00:00:00 EST 2014
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.
Blood
Kliche S,Worbs T,Wang X,Degen J,Patzak I,Meineke B,Togni M,Moser M,Reinhold A,Kiefer F,Freund C,Förster R,Schraven B
16-0031 was used in Immunoprecipitation to investigate mechanisms for the activation of LFA-1 and its role within the immune system.
Thu Jan 19 00:00:00 EST 2012
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.
Circulation research
Corsten MF,Papageorgiou A,Verhesen W,Carai P,Lindow M,Obad S,Summer G,Coort SL,Hazebroek M,van Leeuwen R,Gijbels MJ,Wijnands E,Biessen EA,De Winther MP,Stassen FR,Carmeliet P,Kauppinen S,Schroen B,Heymans S
16-0031 was used in Flow cytometry/Cell sorting to study how microRNA-155 is upregulated during acute myocarditis, which may contribute to the adverse inflammatory response to viral infection of the heart.
Fri Aug 03 00:00:00 EDT 2012
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.
The Journal of clinical investigation
Li X,Murray F,Koide N,Goldstone J,Dann SM,Chen J,Bertin S,Fu G,Weinstein LS,Chen M,Corr M,Eckmann L,Insel PA,Raz E
16-0031 was used in Flow cytometry/Cell sorting to demonstrate that altering cAMP levels in CD4(+) T cells could provide an immunomodulatory approach targeting specific Th subsets.
Thu Mar 01 00:00:00 EST 2012
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.
The Journal of experimental medicine
Rivollier A,He J,Kole A,Valatas V,Kelsall BL
16-0031 was used in Flow cytometry/Cell sorting to demonstrate the dual capacity of Ly6C(hi) blood MOs, which is dictated by microenvironmental conditions.
Mon Jan 16 00:00:00 EST 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
16-0031 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
16-0031 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia.
Hepatology (Baltimore, Md.)
Lages CS,Simmons J,Chougnet CA,Miethke AG
16-0031 was used in Flow cytometry/Cell sorting to study how increased susceptibility to hepatobiliary injury in Treg-depleted mice was linked to hepatic CD8 expansion and enhanced stimulatory capacity of hepatic DCs.
Sun Jul 01 00:00:00 EDT 2012
An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Murphy KA,Lechner MG,Popescu FE,Bedi J,Decker SA,Hu P,Erickson JR,O'Sullivan MG,Swier L,Salazar AM,Olin MR,Epstein AL,Ohlfest JR
16-0031 was used in Functional assays to investigate the combination of a tumor lysate vaccine with a panel of costimulatory molecules for treatment of gliomas.
Sat Sep 01 00:00:00 EDT 2012
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Clambey ET,McNamee EN,Westrich JA,Glover LE,Campbell EL,Jedlicka P,de Zoeten EF,Cambier JC,Stenmark KR,Colgan SP,Eltzschig HK
16-0031 was used in Flow cytometry/Cell sorting to analyse the transcriptional consequences of ambient hypoxia on a broad panel of T-cell differentiation factors.
Tue Oct 09 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
16-0031 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.
European journal of immunology
Lee D,Kim J,Baker RG,Koretzky GA,Hammer DA
16-0031 was used in Functional assays to investigate the role of SLP-76 in chemokine-triggered T-cell adhesion, showing that SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.
Mon Oct 01 00:00:00 EDT 2012
Pulmonary T cell activation in response to chronic particulate air pollution.
American journal of physiology. Lung cellular and molecular physiology
Deiuliis JA,Kampfrath T,Zhong J,Oghumu S,Maiseyeu A,Chen LC,Sun Q,Satoskar AR,Rajagopalan S
16-0031 was used in Flow cytometry/Cell sorting to investigate the effects of chronically inhaled particulate matter less than 2.5 µm in diameter on inflammatory cell populations in the lungs and systemic circulation of mice.
Wed Feb 15 00:00:00 EST 2012
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Ding Y,Fang X,Wang R,Sun Z
16-0031 was used in Flow cytometry/Cell sorting to conclude that protein kinase C-θ is able to control T cell-mediated immune responses by regulating naive T cell differentiation.
Fri Jun 01 00:00:00 EDT 2012
Two-compartment model of NK cell proliferation: insights from population response to IL-15 stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Zhao YM,French AR
16-0031 was used in Flow cytometry/Cell sorting to investigate the influence of IL-15 on murine NK cell division and death rates using a two-compartment mathematical model, revealing novel insights into the in vitro regulation of NK cell proliferation and providing a foundation for modeling in vivo NK cell responses to viral infections.
Sun Apr 01 00:00:00 EDT 2012
Th2 type inflammation promotes the gradual progression of HPV-infected cervical cells to cervical carcinoma.
Gynecologic oncology
Feng Q,Wei H,Morihara J,Stern J,Yu M,Kiviat N,Hellstrom I,Hellstrom KE
16-0031 was used in Flow cytometry/Cell sorting to study the effect of Th2 inflammation upon the tumorigenesis of cervical cancer in human papillomavirus infected women.
Thu Nov 01 00:00:00 EDT 2012
Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes.
Endocrinology
Kanzaki M,Wada J,Sugiyama K,Nakatsuka A,Teshigawara S,Murakami K,Inoue K,Terami T,Katayama A,Eguchi J,Akiba H,Yagita H,Makino H
16-0031 was used in Flow cytometry/Cell sorting to investigate the galectin-9 and T cell immunoglobulin mucin-3 pathways as a therapeutic target for type 1 diabetes.
Wed Feb 01 00:00:00 EST 2012
Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging.
PloS one
Guo J,Feng Y,Barnes P,Huang FF,Idell S,Su DM,Shams H
16-0031 was used in Flow cytometry/Cell sorting to study reduction of peripheral T cell responses to infection and mimicry of changes of aging after deletion of FoxN1 in the thymic medullary epithelium.
Thu Aug 30 00:00:00 EDT 2012
Murine corneal stroma cells inhibit LPS-induced dendritic cell maturation partially through TGF-β2 secretion in vitro.
Molecular vision
Lu JM,Song XJ,Wang HF,Li XL,Zhang XR
16-0031 was used in Flow cytometry/Cell sorting to investigate the factors that inhibit the maturation of DCs in the central cornea.
Fri Dec 21 00:00:00 EST 2012
Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation.
PloS one
Ehrentraut H,Westrich JA,Eltzschig HK,Clambey ET
16-0031 was used in Functional assays to investigate how extracellular adenosine regulates T cell activation and differentiation.
Thu Jul 05 00:00:00 EDT 2012
MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway.
PloS one
Li M,Cao W,Liu H,Zhang W,Liu X,Cai Z,Guo J,Wang X,Hui Z,Zhang H,Wang J,Wang L
16-0031 was used in Functional assays to study how MCPIP1 may play an important role in the down-regulation of IL-2 in activated T lymphocytes by an ARE-independent pathway.
Thu May 30 00:00:00 EDT 2013
Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
BMC gastroenterology
Majowicz A,van der Marel S,te Velde AA,Meijer SL,Petry H,van Deventer SJ,Ferreira V
16-0031 was used in Flow cytometry/Cell sorting to identify a new method to generate in vitro iTreg cells (TregPMA cells) with demonstrated functionality in vivo.
Mon Dec 03 00:00:00 EST 2012
Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.
Frontiers in immunology
Chevrier S,Genton C,Malissen B,Malissen M,Acha-Orbea H
16-0031 was used in Flow cytometry/Cell sorting to determine that CD80 and CD86 costimulators play a key role in the polyclonal B cell activation mediated by Lat(Y136F) CD4(+) T cells.
Thu Aug 23 00:00:00 EDT 2012
Intranasal administration of dsRNA analog poly(I:C) induces interferon-α receptor-dependent accumulation of antigen experienced T cells in the airways.
PloS one
McNally B,Willette M,Ye F,Partida-Sanchez S,Flaño E
16-0031 was used in Flow cytometry/Cell sorting to elucidate the airway immune cell response to intranasally administered poly(I:C).
Tue Jun 11 00:00:00 EDT 2013
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells.
Nature immunology
Feng X,Wang H,Takata H,Day TJ,Willen J,Hu H
16-0031 was used in Western Blotting to provide evidence that Foxp1 plays an indispensable role in maintaining naive T cell quiescence, in part by repressing IL-7Rα expression.
Wed Jun 01 00:00:00 EDT 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
16-0031 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
EpiChIP: gene-by-gene quantification of epigenetic modification levels.
Nucleic acids research
Hebenstreit D,Gu M,Haider S,Turner DJ,Liò P,Teichmann SA
16-0031 was used in Functional assays to develop a software package that analyses ChIP-seq data in order to quantify epigenetic modification levels for individual genes.
Tue Mar 01 00:00:00 EST 2011
Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Lal G,Yin N,Xu J,Lin M,Schroppel S,Ding Y,Marie I,Levy DE,Bromberg JS
16-0031 was used in Functional assays to investigate how different inflammatory signals affect Foxp3 expression and Tregs plasticity, showing that distinct signals have physiologically divergent effects on Foxp3 epigenetic regulation.
Tue Feb 01 00:00:00 EST 2011
T-bet-mediated differentiation of the activated CD8+ T cell.
European journal of immunology
Yeo CJ,Fearon DT
16-0031 was used in in vitro experiments to develop an in vitro system of ectopic T-bet expression to determine the role of T-bet in the differentiation of short-lived effector CD8+ T cells.
Sat Jan 01 00:00:00 EST 2011
Suppressors of cytokine signaling inhibit effector T cell responses during Mycobacterium tuberculosis infection.
Immunology and cell biology
Srivastava V,Vashishta M,Gupta S,Singla R,Singla N,Behera D,Natarajan K
16-0031 was used in Functional assays to characterise the role of SOCS1 in regulating effector responses from CD4(+) and CD8(+) T cells during M. tuberculosis infection, showing that SOCS1 inhibits effector T cell response during infection.
Sat Oct 01 00:00:00 EDT 2011
T Cell Stimulatory Effects of Korean Red Ginseng through Modulation of Myeloid-Derived Suppressor Cells.
Journal of ginseng research
Jeon C,Kang S,Park S,Lim K,Hwang KW,Min H
16-0031 was used in Functional assays to investigate the effects of Korean red ginseng (KRG) on myeloid-derived suppressor cells (MDSCs) in tumour-bearing mice and evaluate immunostimulatory and anti-tumor activities of KRG.
Tue Nov 01 00:00:00 EDT 2011
SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Peterson LK,Shaw LA,Joetham A,Sakaguchi S,Gelfand EW,Dragone LL
16-0031 was used in Western Blotting to show that SLAP deficiency increases TCR signalling, which enhances the development and function of Tregs to prevent arthritis development in a KO mouse model.
Tue Feb 15 00:00:00 EST 2011
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
Journal of immunology (Baltimore, Md. : 1950)
MacIver NJ,Blagih J,Saucillo DC,Tonelli L,Griss T,Rathmell JC,Jones RG
16-0031 was used in Immunopurification to demonstrate that Liver Kinase B1 is a critical regulator of T cell development, viability, activation, and metabolism.
Sat Oct 15 00:00:00 EDT 2011
Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration.
Journal of immunology (Baltimore, Md. : 1950)
Deslauriers AM,Afkhami-Goli A,Paul AM,Bhat RK,Acharjee S,Ellestad KK,Noorbakhsh F,Michalak M,Power C
16-0031 was used in Functional assays to investigate whether ER stress is an integral component of neuroinflammation and contributes to the development of neurological diseases.
Tue Nov 01 00:00:00 EDT 2011
Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wollenberg I,Agua-Doce A,Hernández A,Almeida C,Oliveira VG,Faro J,Graca L
16-0031 was used in Functional assays to investigate the role of Foxp3+ follicular regulatory T-cells in regulating humoral immune responses.
Tue Nov 01 00:00:00 EDT 2011
IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.
International immunology
Mori T,Miyamoto T,Yoshida H,Asakawa M,Kawasumi M,Kobayashi T,Morioka H,Chiba K,Toyama Y,Yoshimura A
16-0031 was used in Functional assays to elucidate the role of cytokines in chronic inflammation and joint destruction in rheumatoid arthritis.
Tue Nov 01 00:00:00 EDT 2011
RNA sequencing reveals two major classes of gene expression levels in metazoan cells.
Molecular systems biology
Hebenstreit D,Fang M,Gu M,Charoensawan V,van Oudenaarden A,Teichmann SA
16-0031 was used in Functional assays to investigate the global distribution of gene expression levels, suggesting that genes can be separated into two distinct groups: one group comprised of lowly expressed and putatively non-functional mRNAs, and the other of highly expressed mRNAs with active chromatin marks at their promoters.
Tue Jun 07 00:00:00 EDT 2011
Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells.
PloS one
Wang L,Lin J,Zhou Z,Huo R,Shen B,Sun Y,Li N
16-0031 was used in Functional assays to implicate up-regulated Th17 development as a mechanism of enhancing anti-tumour immunity.
Fri May 18 00:00:00 EDT 2012
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
Immunity
Mukasa R,Balasubramani A,Lee YK,Whitley SK,Weaver BT,Shibata Y,Crawford GE,Hatton RD,Weaver CT
16-0031 was used in Functional assays to reveal that the plasticity of the T helper 17 cell line is a result of the epigenetic instability of cytokine and transcription factor gene loci.
Fri May 28 00:00:00 EDT 2010
Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.
The Journal of allergy and clinical immunology
Jin SL,Goya S,Nakae S,Wang D,Bruss M,Hou C,Umetsu D,Conti M
16-0031 was used in Functional assays to demonstrate that PDE4B plays an essential role in Th2-cell activation and dendritic cell recruitment during airway inflammation in allergen-sensitised mice.
Wed Dec 01 00:00:00 EST 2010
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.
Proceedings of the National Academy of Sciences of the United States of America
Ishikawa E,Miyake Y,Hara H,Saito T,Yamasaki S
16-0031-82 was used in Western Blotting to investigate the mechanism underlying this ligand-independent pre-T-cell receptor (TCR) signalling in vivo, showing that germ-line elimination of electric charge on pre-T-cell receptor impairs autonomous signaling for beta-selection and TCR repertoire formation.
Tue Nov 16 00:00:00 EST 2010
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
16-0031 was used in in vitro experiments to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 EDT 2010
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
16-0031 was used in Functional assays to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
16-0031 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.
Journal of immunology (Baltimore, Md. : 1950)
Reijmers RM,Vondenhoff MF,Roozendaal R,Kuil A,Li JP,Spaargaren M,Pals ST,Mebius RE
16-0031 was used in Flow cytometry/Cell sorting to investigate how modification of HS by Glce is required for controlling the activity of molecules that are instructive for early lymphoid tissue morphogenesis.
Thu Apr 01 00:00:00 EDT 2010
B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.
Journal of immunology (Baltimore, Md. : 1950)
DiLillo DJ,Yanaba K,Tedder TF
16-0031 was used in Flow cytometry/Cell sorting to quantify B cell contributions to T cell-mediated anti-tumour immune responses.
Thu Apr 01 00:00:00 EDT 2010
Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusion.
Kidney international
Chen SW,Kim M,Kim M,Song JH,Park SW,Wells D,Brown K,Belleroche Jd,D'Agati VD,Lee HT
16-0031 was used in Flow cytometry/Cell sorting to investigate increased renal injury in mice that overexpress human heat shock protein 27 following ischemia reperfusion.
Sun Mar 01 00:00:00 EST 2009
Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses.
Cancer research
Edukulla R,Woller N,Mundt B,Knocke S,Gürlevik E,Saborowski M,Malek N,Manns MP,Wirth T,Kühnel F,Kubicka S
16-0031 was used in Immunohistochemistry on paraffin embedded tissues to investigate the effect of virotherapy in conjunction with MIP-1alpha and Flt3L in treating primary tumours, showing that triggering dendritic cell and T-cell infiltration can enhance treatment.
Sun Feb 15 00:00:00 EST 2009
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
16-0031 was used in Immunohistochemistry to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 EST 2009
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
16-0031 was used in Immunohistochemistry to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 EST 2009
Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.
Journal of leukocyte biology
Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D
16-0031 was used in Western Blotting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..
Tue Sep 01 00:00:00 EDT 2009
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chang M,Lee AJ,Fitzpatrick L,Zhang M,Sun SC
16-0031 was used in Functional assays to investigate the physiological functions of NF-kappaB inhibitors, showing that p105 regulates T cell homeostasis and prevents chronic inflammation.
Sun Mar 01 00:00:00 EST 2009
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis.
Journal of immunology (Baltimore, Md. : 1950)
Manocha M,Rietdijk S,Laouar A,Liao G,Bhan A,Borst J,Terhorst C,Manjunath N
16-0031 was used in Functional assays to investigate whether interfering with the interaction between CD70 and CD27 would affect the development of colitis.
Wed Jul 01 00:00:00 EDT 2009
Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
Journal of immunology (Baltimore, Md. : 1950)
Tran DQ,Glass DD,Uzel G,Darnell DA,Spalding C,Holland SM,Shevach EM
16-0031 was used in in vitro experiments to investigate the mechanisms of action and cellular targets for Treg-mediated suppression.
Sun Mar 01 00:00:00 EST 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
16-0031 was used in Functional assays to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF.
Journal of immunology (Baltimore, Md. : 1950)
Kolly L,Karababa M,Joosten LA,Narayan S,Salvi R,Pétrilli V,Tschopp J,van den Berg WB,So AK,Busso N
16-0031 was used in Functional assays to investigate the contribution of ASC, NALP-3, IPAF, and caspase-1 to inflammatory arthritis, showing that the inflammatory role of ASC in arthritis is independent of caspase-1, NALP-3, and IPAF.
Tue Sep 15 00:00:00 EDT 2009
Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice.
Cellular immunology
Han GM,Zhao B,Jeyaseelan S,Feng JM
16-0031 was used in Functional assays to investigate the relationship between increased proportion of Foxp3(+) Treg cells and CD44(+) Tem cells with aging.
Tue Aug 25 00:00:00 EDT 2009
Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).
Cell biochemistry and function
Alves BN,Marshall K,Tamang DL,Leong J,Redelman D,Elliott V,Lowe ME,Hudig D
16-0031 was used in Flow cytometry/Cell sorting to question whether the cytotoxic T lymphocyte-derived lipase, PLRP2, could support cytotoxicity toward tumour cells.
Wed Jul 01 00:00:00 EDT 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
16-0031 was used in Functional assays to develop cell-penetrating Ras inhibitors and to study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis; revealing a role of Ras in survival in T cells.
Mon Jan 05 00:00:00 EST 2009
Role of regulatory T cells in coronavirus-induced acute encephalitis.
Virology
Anghelina D,Zhao J,Trandem K,Perlman S
16-0031 was used in Flow cytometry/Cell sorting to show that Tregs may help to limit immunopathological disease without delaying virus clearance in coronavirus-induced acute encephalitis.
Sun Mar 15 00:00:00 EDT 2009
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.
Nature immunology
Xiao C,Srinivasan L,Calado DP,Patterson HC,Zhang B,Wang J,Henderson JM,Kutok JL,Rajewsky K
16-0031 was used in Magnetic cell separation to investigate the mechanism behind the promotion of miR-17-92-induced lymphomagenesis.
Tue Apr 01 00:00:00 EDT 2008
Development of all CD4 T lineages requires nuclear factor TOX.
The Journal of experimental medicine
Aliahmad P,Kaye J
16-0031 was used in Functional assays to investigate the regulation and importance of the early transition from common thymocyte precursors to CD4 and CD8 T cell development.
Mon Jan 21 00:00:00 EST 2008
Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling.
Cancer research
Nishikawa H,Kato T,Hirayama M,Orito Y,Sato E,Harada N,Gnjatic S,Old LJ,Shiku H
16-0031 was used in Flow cytometry/Cell sorting to investigate the potential of incorporating glucocorticoid-induced tumour necrosis factor receptor ligand into cancer vaccines to augment their immunogenicity.
Tue Jul 15 00:00:00 EDT 2008
Micropatterning of costimulatory ligands enhances CD4+ T cell function.
Proceedings of the National Academy of Sciences of the United States of America
Shen K,Thomas VK,Dustin ML,Kam LC
16-0031 was used in Functional assays to investigate the impact of spatial organisation of signalling complexes in the immunological synapse.
Tue Jun 03 00:00:00 EDT 2008
Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.
Computer methods and programs in biomedicine
Rebhahn JA,Bishop C,Divekar AA,Jiminez-Garcia K,Kobie JJ,Lee FE,Maupin GM,Snyder-Cappione JE,Zaiss DM,Mosmann TR
16-0031 was used in an ELISpot assay to develop an automated counting program to detect and quantify Fluorospots in automated fluorescence microscope images.
Wed Oct 01 00:00:00 EDT 2008
Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.
Computer methods and programs in biomedicine
Rebhahn JA,Bishop C,Divekar AA,Jiminez-Garcia K,Kobie JJ,Lee FE,Maupin GM,Snyder-Cappione JE,Zaiss DM,Mosmann TR
16-0031 was used in an ELISpot assay to develop an automated counting program to detect and quantify Fluorospots in automated fluorescence microscope images.
Wed Oct 01 00:00:00 EDT 2008
Dynamics of lung macrophage activation in response to helminth infection.
Journal of leukocyte biology
Siracusa MC,Reece JJ,Urban JF,Scott AL
16-0031 was used in Flow cytometry/Cell sorting to characterise the surface molecules, gene expression, and cell function of macrophages isolated from lung tissue after helminth infection.
Mon Dec 01 00:00:00 EST 2008
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Subleski JJ,Kopf H,Howard OM,Männel DN,Oppenheim JJ
16-0031 was used in Flow cytometry/Cell sorting to characterise the phenotype and function of TNFR2(+) Tregs in peripheral lymphoid tissues, showing that expression defines a suppressive subset of Tregs that accumulate intratumourally.
Thu May 15 00:00:00 EDT 2008
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Subleski JJ,Kopf H,Howard OM,Männel DN,Oppenheim JJ
16-0031 was used in Flow cytometry/Cell sorting to characterise the phenotype and function of TNFR2(+) Tregs in peripheral lymphoid tissues, showing that expression defines a suppressive subset of Tregs that accumulate intratumourally.
Thu May 15 00:00:00 EDT 2008
Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lapinski PE,Oliver JA,Kamen LA,Hughes ED,Saunders TL,King PD
16-0031 was used in Functional assays to investigate the mechanisms underlying negative regulation of IL-2 synthesis by ALX.
Fri Aug 01 00:00:00 EDT 2008
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.
Journal of immunology (Baltimore, Md. : 1950)
Matsumura S,Wang B,Kawashima N,Braunstein S,Badura M,Cameron TO,Babb JS,Schneider RJ,Formenti SC,Dustin ML,Demaria S
16-0031 was used in Functional assays to investigate the factors regulating recruitment of effector T cells to tumours.
Mon Sep 01 00:00:00 EDT 2008
Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway.
Immunology letters
Chen J,Panchanathan R,Choubey D
16-0031 was used in Functional assays to elucidate the signalling pathways that regulate Ifi202 expression in immune cells.
Sun Jun 15 00:00:00 EDT 2008
Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease.
Experimental hematology
Tawara I,Maeda Y,Sun Y,Lowler KP,Liu C,Toubai T,McKenzie AN,Reddy P
16-0031 was used in Functional assays to investigate the role of Th1 and Th2 polarization in acute graft-vs-host-disease, showing that combined Th2 cytokine deficiency in donor T cells aggravates disease.
Fri Aug 01 00:00:00 EDT 2008
p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
PloS one
Cheng N,van de Wetering CI,Knudson CM
16-0031 was used in Functional assays to study the relationship between p27 and Bcl-2 in cell proliferation and cancer, showing that p27 loss promotes B cell lymphoma in Lck-Bcl-2 mice but not Lck-Bax mice.
Wed Apr 02 00:00:00 EDT 2008
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
PloS one
Hase K,Takahashi D,Ebisawa M,Kawano S,Itoh K,Ohno H
16-0031 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying autoimmunity associated with AID mutations, showing that AID is a negative regulator of autoreactive B cells.
Thu Aug 21 00:00:00 EDT 2008
The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Chae WJ,Henegariu O,Lee SK,Bothwell AL
16-0031 was used in Functional assays to show that deletion of glutamic acid in the leucine-zipper domain of Foxp3 causes loss of hyporesponsiveness upon antigenic stimulation.
Tue Jun 20 00:00:00 EDT 2006
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
International journal of cancer
Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH
Thu Jun 01 00:00:00 EDT 2006
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.
The Journal of experimental medicine
Pop SM,Wong CP,Culton DA,Clarke SH,Tisch R
16-0031 was used in Functional assays to investigate the interactions between CD4(+)CD25(+) T reg cells and autoreactive T cells.
Mon Apr 18 00:00:00 EDT 2005
Amotosalen-treated donor T cells have polyclonal antigen-specific long-term function without graft-versus-host disease after allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Hossain MS,Roback JD,Lezhava L,Hillyer CD,Waller EK
16-0031 was used in Functional assays to investigate the effects of amotosalen-treated donor T cells on immune reconstitution after allogeneic bone marrow transplantation.
Tue Mar 01 00:00:00 EST 2005
Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Krieg C,Han P,Stone R,Goularte OD,Kaye J
Tue Nov 15 00:00:00 EST 2005
CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.
Investigative ophthalmology & visual science
Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M
Sat Oct 01 00:00:00 EDT 2005
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling.
Infection and immunity
Sturm A,Rilling K,Baumgart DC,Gargas K,Abou-Ghazalé T,Raupach B,Eckert J,Schumann RR,Enders C,Sonnenborn U,Wiedenmann B,Dignass AU
16-0031 was used in Functional assays to analyze the effects of Escherichia coli Nissle 1917 on cell cycling and apoptosis of peripheral blood and lamina propria T-cells.
Tue Mar 01 00:00:00 EST 2005
The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion.
Journal of immunology (Baltimore, Md. : 1950)
Hadzic T,Li L,Cheng N,Walsh SA,Spitz DR,Knudson CM
16-0031-82 was used in Flow cytometry/Cell sorting to demonstrate that T cell proliferation is regulated by thiol-sensitive pathway involving IL-2.
Thu Dec 15 00:00:00 EST 2005
Bcl-2 inhibition of T-cell proliferation is related to prolonged T-cell survival.
Oncogene
Cheng N,Janumyan YM,Didion L,Van Hofwegen C,Yang E,Knudson CM
16-0031 was used in Flow cytometry/Cell sorting to assess whether Bcl-2 and Bax regulate T-cell proliferation through driving changes in T-cell size and by increasing the expression of quiescence markers.
Thu May 06 00:00:00 EDT 2004
