Invitrogen

CD3e Monoclonal Antibody (145-2C11), APC, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

97 Published Figures

224 References

View all (504) CD3 antibodies

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CD3e Antibody (17-0031-82) in Flow

Staining of C57Bl/6 splenocytes with Anti-Human/Mouse CD45R (B220) FITC (Product # 11-0452-82) and 0.125 µg of Armenian Hamster IgG Isotype Control APC (Product # 17-4888-82) (left) or 0.125 µg of Anti-Mouse CD3e APC (right). Total viable cells were used for analysis.

Product Image Gallery

CD3e Antibody — Figure 4 MOG35-55/I-A b dimer modulates the expression of CD3 and TCR as well as the mTGF-beta1 and IL-10 suppressive cytokines in MOG35-55-specific T cells. (A-D) The 2D2 splenocytes were stimulated with MOG35-55 (25 ug/mL) in vitro in the presence of MOG35-55/I-A b dimer (1.2 nM) or PBS. After 5 days culture, cells were harvest and stained with anti-CD4-FITC mAb, anti-CD3-PE-Cy7 mAb, anti-TCR-Valpha3.2-APC mAb, anti-mTGF-beta1-PE and/or anti-IL-10-PE mAb. (A-B) The MFIs of (A) PE-cy7-CD3 and (B) APC-TCR Valpha3.2 on CD4 + cells were analyzed by flow cytometry and expressed as the mean +- SD from 6 mice in each group. (C-D) MOG35-55/I-A b dimer intervention induced a population of CD3 low TCR low CD4 + cells with high level of (C) mTGF-beta1 and (D) IL-10 expression. The right panel represents the mean +- SD of MFI of PE-mTGF-beta1 and PE-IL-10 on CD3 high TCR high CD4 + /CD3 low TCR low CD4 + cells in dimer intervention group (n = 3). (E) Splenocytes were isolated from mice treated with PBS or MOG35-55/I-A b dimer on day 18 post-immunization and stained with anti-CD3-APC, anti-CD4-FITC, anti-TGF-beta1-PE, and/or anti-IL-10-PE Abs. CD4 + cells were gated for analysis by flow cytometry. (a-b) The mean percentage of CD3 low CD4 + cells and the MFI of APC-CD3 on CD4 + cells from 6 mice in each group are represented as the mean +- SD. (c) The MFIs of PE-mTGF-beta1 and PE-IL-10 on CD3 low CD4 + /CD3 high CD4 + cells in dimer treated-group are expressed as the mean +- SD from 6 mi {TM}

Product Details

17-0031-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Flow Cytometry (Flow)

0.25 µg/test

View 213 publications 213 publications

Functional Assay (Functional)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), APC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

145-2C11

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_469315

Product Specific Information

Description: The 145-2C11 monoclonal antibody reacts with mouse CD3e, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits, gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Binding of 145-2C11 to TCR initiates the intracellular biochemical pathway resulting in cellular activation, proliferation, and apoptosis depending on specific conditions utilized. 145-2C11 is commonly used as a phenotypic marker for mouse T cells.

Applications Reported: The 145-2C11 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The 145-2C11 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy.

NPJ vaccines

Teymournejad O,Li Z,Beesetty P,Yang C,Montgomery CP

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Jan 24 00:00:00 EST 2023

NCR negative group 3 innate lymphoid cell (NCR^- ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.

Immunity, inflammation and disease

Chu S,Ma L,Yang X,Xiao B,Liang Y,Zheng S,Li L

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

NCR negative group 3 innate lymphoid cell (NCR^- ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.

Immunity, inflammation and disease

Chu S,Ma L,Yang X,Xiao B,Liang Y,Zheng S,Li L

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.

iScience

Zhou J,Wang H,Shu T,Wang J,Yang W,Li J,Ding L,Liu M,Sun H,Wong J,Lai PB,Tsang SW,Ward SE,Chow KL,Sung JJ,Sze-Lok Cheng A

17-0031-82 was used in Flow cytometry/Cell sorting to demonstrated that cell cycle-related kinase (CCRK) is upregulated in myeloid cells in tumor-bearing mice and in patients with hepatocellular carcinoma.

Fri Oct 20 00:00:00 EDT 2023

Molecular Imaging of Oxygenation Changes during Immunotherapy in Combination with Paclitaxel in Triple Negative Breast Cancer.

Biomedicines

Napier TS,Lynch SE,Lu Y,Song PN,Burns AC,Sorace AG

17-0031-82 was used in Flow cytometry/Cell sorting to provide insights into how PEF protein dynamics affect secretion of important physiological cargoes such as collagen I and significantly impact ER stress.

Wed Jan 04 00:00:00 EST 2023

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.

Diabetes

Luan D,Dadpey B,Zaid J,Bridge-Comer PE,DeLuca JH,Xia W,Castle J,Reilly SM

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.

Nature medicine

Ganan-Gomez I,Yang H,Ma F,Montalban-Bravo G,Thongon N,Marchica V,Richard-Carpentier G,Chien K,Manyam G,Wang F,Alfonso A,Chen S,Class C,Kanagal-Shamanna R,Ingram JP,Ogoti Y,Rose A,Loghavi S,Lockyer P,Cambo B,Muftuoglu M,Schneider S,Adema V,McLellan M,Garza J,Marchesini M,Giuliani N,Pellegrini M,Wang J,Walker J,Li Z,Takahashi K,Leverson JD,Bueso-Ramos C,Andreeff M,Clise-Dwyer K,Garcia-Manero G,Colla S

17-0031-82 was used in Flow Cytometry to study the biological mechanisms that drive hypomethylating agent therapy failure at the stem-cell level to uncover vulnerabilities in the disease and halt its evolution.

Tue Mar 01 00:00:00 EST 2022

Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.

Nature communications

Lin C,Yang Q,Guo D,Xie J,Yang YS,Chaugule S,DeSouza N,Oh WT,Li R,Chen Z,John AA,Qiu Q,Zhu LJ,Greenblatt MB,Ghosh S,Li S,Gao G,Haynes C,Emerson CP,Shim JH

17-0031-82 was used in Flow cytometry/Cell sorting to identify mitochondrial oxidative phosphorylation as the prominent energy-driving force for osteogenesis of skeletal progenitors, governing musculoskeletal integrity.

Fri Nov 11 00:00:00 EST 2022

Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging.

Nature methods

Haase C,Gustafsson K,Mei S,Yeh SC,Richter D,Milosevic J,Turcotte R,Kharchenko PV,Sykes DB,Scadden DT,Lin CP

17-0031-82 was used in Flow cytometry/Cell sorting to present Image-seq, a technology that provides single-cell transcriptional data on cells that are isolated from specific spatial locations under image guidance, thus preserving the spatial information of the target cells.

Thu Dec 01 00:00:00 EST 2022

A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.

Journal of cellular and molecular medicine

Wei DP,Li DD,Gu AQ,Ji WH,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.

The European journal of neuroscience

Frühauf M,Zeitschel U,Höfling C,Ullm F,Rabiger FV,Alber G,Pompe T,Müller U,Roßner S

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.

The European journal of neuroscience

Frühauf M,Zeitschel U,Höfling C,Ullm F,Rabiger FV,Alber G,Pompe T,Müller U,Roßner S

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.

The Journal of biological chemistry

McAndrews KM,Che SPY,LeBleu VS,Kalluri R

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Aug 20 00:00:00 EDT 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Sat Jan 30 00:00:00 EST 2021

Obesity results in adipose tissue T cell exhaustion.

JCI insight

Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.

iScience

Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.

iScience

Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Nature communications

Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Jul 14 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.

Journal of neuroinflammation

Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ

17-0031-82 was used in Flow Cytometry to provide an instructive basis for the roles of Smek1 in EAE and broaden the understanding of the genetic factors involved in the pathogenesis of autoimmune demyelination.

Mon Jun 28 00:00:00 EDT 2021

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche.

Cell stem cell

Kfoury YS,Ji F,Mazzola M,Sykes DB,Scherer AK,Anselmo A,Akiyama Y,Mercier F,Severe N,Kokkaliaris KD,Zhao T,Brouse T,Saez B,Seidl J,Papazian A,Ivanov P,Mansour MK,Sadreyev RI,Scadden DT

17-0031-82 was used in Flow cytometry/Cell sorting to show that extracellular vesicle-mediated tiRNA transfer provides a stress-modulated signalling axis, distinct from conventional stress responses, in the bone marow niche.

Thu Dec 02 00:00:00 EST 2021

PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.

Frontiers in immunology

Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L

17-0031-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.

Mon Feb 28 00:00:00 EST 2022

Combined Prebiotic and Microbial Intervention Improves Oral Cholera Vaccination Responses in a Mouse Model of Childhood Undernutrition.

Cell host & microbe

Di Luccia B,Ahern PP,Griffin NW,Cheng J,Guruge JL,Byrne AE,Rodionov DA,Leyn SA,Osterman AL,Ahmed T,Colonna M,Barratt MJ,Delahaye NF,Gordon JI

17-0031-82 was used in Flow Cytometry to provide preclinical proof-of-concept that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candidate synbiotic formulation.

Wed Jun 10 00:00:00 EDT 2020

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.

Developmental cell

Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM

17-0031 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.

Mon Apr 20 00:00:00 EDT 2020

Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells.

Cancer immunology research

Wijewarnasuriya D,Bebernitz C,Lopez AV,Rafiq S,Brentjens RJ

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Critical role of OX40 in drug-induced acute liver injury.

British journal of pharmacology

Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D

17-0031-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.

Wed Jul 01 00:00:00 EDT 2020

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yamane M,Sato S,Shimizu E,Shibata S,Hayano M,Yaguchi T,Kamijuku H,Ogawa M,Suzuki T,Mukai S,Shimmura S,Okano H,Takeuchi T,Kawakami Y,Ogawa Y,Tsubota K

17-0031-82 was used in Immunohistochemistry to elucidate an additional pathway of chronic ocular chronic graft-vs-host disease.

Sat Aug 01 00:00:00 EDT 2020

Antitumor Effect and Immune Response of Nanosecond Pulsed Electric Fields in Pancreatic Cancer.

Frontiers in oncology

Zhao J,Chen S,Zhu L,Zhang L,Liu J,Xu D,Tian G,Jiang T

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Impact of S1P Mimetics on Mesenteric Ischemia/Reperfusion Injury.

Pharmaceuticals (Basel, Switzerland)

Potì F,Giorgio C,Zini I,Nofer JR,Vivo V,Palese S,Ballabeni V,Barocelli E,Bertoni S

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Oct 09 00:00:00 EDT 2020

CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.

FEBS open bio

Liu Y,Gao Y,Hao H,Hou T

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

IDO1⁺ Paneth cells promote immune escape of colorectal cancer.

Communications biology

Pflügler S,Svinka J,Scharf I,Crncec I,Filipits M,Charoentong P,Tschurtschenthaler M,Kenner L,Awad M,Stift J,Schernthanner M,Bischl R,Herndler-Brandstetter D,Glitzner E,Moll HP,Casanova E,Timelthaler G,Sibilia M,Gnant M,Lax S,Thaler J,Müller M,Strobl B,Mohr T,Kaser A,Trajanoski Z,Heller G,Eferl R

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.

Cell reports

Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Jun 17 00:00:00 EDT 2021

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.

Cell reports

Miyamoto R,Okuda H,Kanai A,Takahashi S,Kawamura T,Matsui H,Kitamura T,Kitabayashi I,Inaba T,Yokoyama A

17-0031-82 was used in Flow Cytometry to reveal that activation of unmethylated CpG-rich promoters mediated by MLL is the central mechanism of oncogenic self-renewal in MOZ-rearranged leukemia.

Tue Sep 29 00:00:00 EDT 2020

Bee Venom Phospholipase A2 Ameliorates Atherosclerosis by Modulating Regulatory T Cells.

Toxins

Kang GH,Lee S,Choi DB,Shin D,Kim J,Yang H,Bae H

17-0031-82 was used in Flow Cytometry to investigate bee venom phospholipase A2 (bvPLA2) as a potential therapeutic agent in atherosclerosis.

Wed Sep 23 00:00:00 EDT 2020

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.

Oncoimmunology

Cervera-Carrascon V,Quixabeira DCA,Santos JM,Havunen R,Zafar S,Hemminki O,Heiniö C,Munaro E,Siurala M,Sorsa S,Mirtti T,Järvinen P,Mildh M,Nisen H,Rannikko A,Anttila M,Kanerva A,Hemminki A

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jun 19 00:00:00 EDT 2020

Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome.

Frontiers in immunology

Hou L,Yang L,Chang N,Zhao X,Zhou X,Dong C,Liu F,Yang L,Li L

17-0031 was used in Flow cytometry/Cell sorting to show that targeting macrophage S1PR2 retarded liver inflammation and fibrogenesis via downregulating NLRP3 inflammasome.

Thu Apr 01 00:00:00 EDT 2021

Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.

iScience

Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T

17-0031 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.

Fri Jul 24 00:00:00 EDT 2020

Deciphering CD4⁺ T cell specificity using novel MHC-TCR chimeric receptors.

Nature immunology

Kisielow J,Obermair FJ,Kopf M

17-0031 was used in Flow cytometry/Cell sorting to describe a platform for the discovery of MHC class II epitopes based on the screening of engineered reporter cells expressing novel pMHC-TCR (MCR) hybrid molecules carrying cDNA-derived peptides.

Wed May 01 00:00:00 EDT 2019

Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.

The Journal of allergy and clinical immunology

Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A

17-0031 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.

Wed May 01 00:00:00 EDT 2019

CHK1 dosage in germinal center B cells controls humoral immunity.

Cell death and differentiation

Schoeler K,Jakic B,Heppke J,Soratroi C,Aufschnaiter A,Hermann-Kleiter N,Villunger A,Labi V

17-0031-82 was used in Immunohistochemistry-immunofluorescence to show that the DNA damage response regulator Checkpoint kinase 1 (CHK1) is essential for GC B cell survival.

Sun Dec 01 00:00:00 EST 2019

Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.

Cancer immunology research

Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR

17-0031 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.

Mon Apr 01 00:00:00 EDT 2019

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.

Haematologica

Di Genua C,Norfo R,Rodriguez-Meira A,Wen WX,Drissen R,Booth CAG,Povinelli B,Repapi E,Gray N,Carrelha J,Kettyle LM,Jamieson L,Neo WH,Thongjuea S,Nerlov C,Mead AJ

17-0031 was used in Flow cytometry/Cell sorting to study the mechanism behind absence of KRAS signalling mutations in pre-malignant hematopoietic stem cell compartments.

Fri Nov 01 00:00:00 EDT 2019

1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension.

British journal of pharmacology

Mikolajczyk TP,Nosalski R,Skiba DS,Koziol J,Mazur M,Justo-Junior AS,Kowalczyk P,Kusmierczyk Z,Schramm-Luc A,Luc K,Maffia P,Graham D,Kiss AK,Naruszewicz M,Guzik TJ

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.

Cell death & disease

Gao J,Peng S,Shan X,Deng G,Shen L,Sun J,Jiang C,Yang X,Chang Z,Sun X,Feng F,Kong L,Gu Y,Guo W,Xu Q,Sun Y

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

CD160 serves as a negative regulator of NKT cells in acute hepatic injury.

Nature communications

Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Jul 22 00:00:00 EDT 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.

Nature communications

Kang YH,Biswas A,Field M,Snapper SB

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.

Cell reports

Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B

17-0031 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.

Tue Feb 26 00:00:00 EST 2019

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.

Cell reports

Olson WJ,Jakic B,Labi V,Schoeler K,Kind M,Klepsch V,Baier G,Hermann-Kleiter N

17-0031-82 was used in Immunohistochemistry to investigate the effects of orphan nuclear receptor NR2F6 on accumulation and survival of T follicular helper cells.

Tue Sep 10 00:00:00 EDT 2019

Maternal vaccination and protective immunity against Zika virus vertical transmission.

Nature communications

Shan C,Xie X,Luo H,Muruato AE,Liu Y,Wakamiya M,La JH,Chung JM,Weaver SC,Wang T,Shi PY

17-0031-82 was used in Flow cytometry/Cell sorting to suggest that, besides vaccinating non-pregnant individuals, 3'UTR-?10-LAV may also be considered for maternal vaccination.

Thu Dec 12 00:00:00 EST 2019

Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8⁺ T Cells.

Cell reports

Tomaru U,Konno S,Miyajima S,Kimoto R,Onodera M,Kiuchi S,Murata S,Ishizu A,Kasahara M

17-0031 was used in Flow cytometry/Cell sorting to find that thymoproteasomes are essential for positive selection but that the subsequent change in peptide repertoire in the medulla is also crucial for thymic selection and that β5t-derived peptide must be confined to the thymus to avoid autoimmunity in peripheral tissues.

Tue Jan 15 00:00:00 EST 2019

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.

Immunity

Brazin KN,Mallis RJ,Boeszoermenyi A,Feng Y,Yoshizawa A,Reche PA,Kaur P,Bi K,Hussey RE,Duke-Cohan JS,Song L,Wagner G,Arthanari H,Lang MJ,Reinherz EL

17-0031 was used in Flow cytometry/Cell sorting to suggest that mechanical forces applied during pMHC ligation initiate T cell activation via a dissociative mechanism, shifting disposition of those basic sidechains to rearrange TCR complex membrane topology and weaken TCRαβ and CD3 associations.

Tue Nov 20 00:00:00 EST 2018

E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.

Immunity

Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC

17-0031 was used in Immunohistochemistry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.

Tue Feb 20 00:00:00 EST 2018

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.

The Journal of experimental medicine

Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE

17-0031 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.

Mon Jul 02 00:00:00 EDT 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

Role of Hepatic Deposited Immunoglobulin G in the Pathogenesis of Liver Damage in Systemic Lupus Erythematosus.

Frontiers in immunology

Fang X,Zaman MH,Guo X,Ding H,Xie C,Zhang X,Deng GM

17-0031 was used in Flow cytometry/Cell sorting to investigate the role of hepatic deposited immunoglobulin G in systemic lupus erythematosus-derived liver damage.

Wed Nov 20 00:00:00 EST 2019

Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice.

PLoS pathogens

Skalski JH,Limon JJ,Sharma P,Gargus MD,Nguyen C,Tang J,Coelho AL,Hogaboam CM,Crother TR,Underhill DM

17-0031 was used in Flow cytometry/Cell sorting to investigate the effects of the population expansion of commensal fungus Wallemia mellicola without overgrowth of the total fungal community.

Sat Sep 01 00:00:00 EDT 2018

Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh.

Development (Cambridge, England)

Solanki A,Yanez DC,Ross S,Lau CI,Papaioannou E,Li J,Saldaña JI,Crompton T

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Jan 31 00:00:00 EST 2018

On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation.

Drug delivery

Shahzad KA,Wan X,Zhang L,Pei W,Zhang A,Younis M,Wang W,Shen C

17-0031 was used in Flow cytometry/Cell sorting to examine the direct and antigen-specific modulation on T cells by nanoparticles and combined use of multiple regulatory molecules.

Thu Nov 01 00:00:00 EDT 2018

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Journal of neuroimmunology

Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response.

Scientific reports

Rodríguez-Baena FJ,Redondo-García S,Peris-Torres C,Martino-Echarri E,Fernández-Rodríguez R,Plaza-Calonge MDC,Anderson P,Rodríguez-Manzaneque JC

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Aug 30 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.

Cell stem cell

Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L

17-0031 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.

Thu May 03 00:00:00 EDT 2018

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Cell reports

Omata Y,Frech M,Primbs T,Lucas S,Andreev D,Scholtysek C,Sarter K,Kindermann M,Yeremenko N,Baeten DL,Andreas N,Kamradt T,Bozec A,Ramming A,Krönke G,Wirtz S,Schett G,Zaiss MM

17-0031 was used in Immunohistochemistry to elucidate the role of group 2 innate lymphoid cells in arthritis.

Tue Jul 03 00:00:00 EDT 2018

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Nature communications

Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B

17-0031 was used in Flow cytometry/Cell sorting to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.

Tue May 15 00:00:00 EDT 2018

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.

Nature communications

Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G

17-0031 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.

Wed Apr 18 00:00:00 EDT 2018

Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.

PloS one

Metghalchi S,Vandestienne M,Haddad Y,Esposito B,Dairou J,Tedgui A,Mallat Z,Potteaux S,Taleb S

17-0031 was used in Flow cytometry/Cell sorting to show that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.

Fri Jun 22 00:00:00 EDT 2018

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Immunity, inflammation and disease

Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P

Fri Jun 01 00:00:00 EDT 2018

CD9⁺ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients.

Frontiers in immunology

Brosseau C,Durand M,Colas L,Durand E,Foureau A,Cheminant MA,Bouchaud G,Castan L,Klein M,Magnan A,Brouard S

17-0031 was used in Flow cytometry/Cell sorting to study CD9+ B cell defects in causing lack of regulation of inflammation in patients with severe asthma.

Fri Oct 25 00:00:00 EDT 2019

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Cell

Kortlever RM,Sodir NM,Wilson CH,Burkhart DL,Pellegrinet L,Brown Swigart L,Littlewood TD,Evan GI

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Nov 30 00:00:00 EST 2017

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Cell

Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popović B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpotić A,Allan DSJ,Makrigiannis AP,Jonjić S,Rossjohn J,Carlyle JR

17-0031 was used in Flow cytometry/Cell sorting to identify a viral ligand for the inhibitory and activating NKR-P1 receptors.

Thu Mar 23 00:00:00 EDT 2017

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Immunity

Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY

17-0031 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.

Tue Nov 21 00:00:00 EST 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

PTEN drives Th17 cell differentiation by preventing IL-2 production.

The Journal of experimental medicine

Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Nov 06 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

17-0031 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.

Mon Jun 05 00:00:00 EDT 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells.

EMBO molecular medicine

Draheim M,Wlodarczyk MF,Crozat K,Saliou JM,Alayi TD,Tomavo S,Hassan A,Salvioni A,Demarta-Gatsi C,Sidney J,Sette A,Dalod M,Berry A,Silvie O,Blanchard N

Wed Nov 01 00:00:00 EDT 2017

PI3Kγ Activates Integrin α₄ and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.

Cancer immunology research

Foubert P,Kaneda MM,Varner JA

17-0031 was used in Flow cytometry/Cell sorting to highlight PI3Kγ and integrin α4 as targets for the design of cancer therapeutics.

Wed Nov 01 00:00:00 EDT 2017

An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8⁺ T Cells.

Frontiers in immunology

Wang W,Shahzad KA,Li M,Zhang A,Zhang L,Xu T,Wan X,Shen C

Wed Nov 20 00:00:00 EST 2019

MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.

PLoS pathogens

Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M

17-0031 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.

Mon May 01 00:00:00 EDT 2017

Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.

Oxidative medicine and cellular longevity

Zhang J,Xue X,Han X,Li Y,Lu L,Li D,Fan S

Thu Mar 16 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

T cell-dependent antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies in mice.

European journal of immunology

Akkaya M,Akkaya B,Sheehan PW,Miozzo P,Pena M,Qi CF,Manzella-Lapeira J,Bolland S,Pierce SK

17-0031 was used in Flow cytometry/Cell sorting to compare the outcome of immunisation with the T-cell dependent antigen, NP-conjugated to chicken gamma globulin adjuvanted, with CpG-A or CpG-B, alone or conjugated with the cationic lipid carrier, DOTAP.

Wed Nov 01 00:00:00 EDT 2017

Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.

Journal of cellular and molecular medicine

Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

17-0031 was used in Flow cytometry/Cell sorting to develop a method that enables the isolation of cell-type specific ApoBDs from tissue, bodily fluid and blood-derived samples to 99% purity.

Fri Jan 06 00:00:00 EST 2017

The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.

Nature microbiology

Grau KR,Roth AN,Zhu S,Hernandez A,Colliou N,DiVita BB,Philip DT,Riffe C,Giasson B,Wallet SM,Mohamadzadeh M,Karst SM

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor.

PloS one

Pols TWH,Puchner T,Korkmaz HI,Vos M,Soeters MR,de Vries CJM

17-0031 was used in Flow cytometry/Cell sorting to study the mechanism by which lithocholic acid controls adaptive immunity.

Mon Sep 11 00:00:00 EDT 2017

Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.

Nature communications

Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ

17-0031 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.

Thu Aug 24 00:00:00 EDT 2017

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.

Scientific reports

Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K

17-0031 was used in Immunohistochemistry to help prove the concept that subcutaneous and subconjunctival injection of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD.

Mon Feb 06 00:00:00 EST 2017

Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury.

International journal of molecular sciences

Han X,Xue X,Zhao Y,Li Y,Liu W,Zhang J,Fan S

17-0031 was used in Flow cytometry/Cell sorting to demonstrate that rutin-enriched coriander extract is able to ameliorate ionising radiation-induced haematopoietic injury partly by reducing ionising radiation-induced oxidative stress.

Sat Apr 29 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Cell

Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D

17-0031 was used in Flow cytometry/Cell sorting to study how OTULIN may be critical in restraining life-threatening spontaneous inflammation and maintaining immune homeostasis.

Thu Aug 25 00:00:00 EDT 2016

Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.

The Journal of clinical investigation

Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J

17-0031 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.

Thu Dec 01 00:00:00 EST 2016

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.

Autophagy

Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2016

Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection.

Proceedings of the National Academy of Sciences of the United States of America

Kim HK,Falugi F,Missiakas DM,Schneewind O

17-0031 was used in Flow cytometry/Cell sorting to suggest that staphylococcal protein A cross-linking of VH3 idiotype BCRs and activation via attached peptidoglycan are determinants of staphylococcal escape from adaptive immune responses.

Tue May 17 00:00:00 EDT 2016

Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.

Mucosal immunology

Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T

17-0031 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.

Thu Sep 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice.

Infection and immunity

Ruan S,Samuelson DR,Assouline B,Morre M,Shellito JE

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation.

Molecular medicine reports

Ren J,Meng S,Yan B,Yu J,Liu J

17-0031 was used in Flow cytometry/Cell sorting to show that protectin D1 reduces concanavalin A-induced liver injury.

Fri Apr 01 00:00:00 EDT 2016

A New Model to Study the Role of Arachidonic Acid in Colon Cancer Pathophysiology.

Cancer prevention research (Philadelphia, Pa.)

Fan YY,Callaway E,M Monk J,S Goldsby J,Yang P,Vincent L,S Chapkin R

17-0031 was used in Flow cytometry/Cell sorting to develop a novel model for the study of arachidonic acid in colon cancer pathophysiology.

Thu Sep 01 00:00:00 EDT 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia.

Oncoimmunology

Finkel P,Frey B,Mayer F,Bösl K,Werthmöller N,Mackensen A,Gaipl US,Ullrich E

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.

Nature communications

Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jul 15 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.

Nature communications

Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Oct 21 00:00:00 EDT 2016

A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo.

Oncotarget

Wang W,Fang K,Li MC,Chang D,Shahzad KA,Xu T,Zhang L,Gu N,Shen CL

17-0031 was used in Flow cytometry/Cell sorting to investigate whether poly(lactic-co-glycolic acid) polyesters can covalently load antigen and mAb to generate killer microparticles able to deplete antigen-specific T cells.

Tue Mar 15 00:00:00 EDT 2016

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.

Nature communications

Szalay G,Martinecz B,Lénárt N,Környei Z,Orsolits B,Judák L,Császár E,Fekete R,West BL,Katona G,Rózsa B,Dénes Á

17-0031 was used in Flow cytometry/Cell sorting to investigate the influence of microglia on neuronal activity and survival in the injured brain in vivo.

Tue May 03 00:00:00 EDT 2016

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii.

JCI insight

El Bissati K,Chentoufi AA,Krishack PA,Zhou Y,Woods S,Dubey JP,Vang L,Lykins J,Broderick KE,Mui E,Suzuki Y,Sa Q,Bi S,Cardona N,Verma SK,Fraczek L,Reardon CA,Sidney J,Alexander J,Sette A,Vedvick T,Fox C,Guderian JA,Reed S,Roberts CW,McLeod R

17-0031 was used in Flow cytometry/Cell sorting to develop multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant to protect against Toxoplasma gondii.

Thu Sep 22 00:00:00 EDT 2016

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

17-0031 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.

Biochimica et biophysica acta

Hersrud SL,Kovács AD,Pearce DA

17-0031 was used in Flow cytometry/Cell sorting to show that CLN3 deficiency alters antigen presenting cells, which can contribute to the autoimmune response in juvenile neuronal ceroid lipofuscinosis.

Fri Jul 01 00:00:00 EDT 2016

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.

The Journal of clinical investigation

Fond AM,Lee CS,Schulman IG,Kiss RS,Ravichandran KS

17-0031 was used in Flow cytometry/Cell sorting to identify a membrane-initiated pathway that is triggered by apoptotic cells to enhance ABCA1 within engulfing phagocytes.

Wed Jul 01 00:00:00 EDT 2015

Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.

The Journal of experimental medicine

Kim PG,Nakano H,Das PP,Chen MJ,Rowe RG,Chou SS,Ross SJ,Sakamoto KM,Zon LI,Schlaeger TM,Orkin SH,Nakano A,Daley GQ

17-0031 was used in Flow cytometry/Cell sorting to identify a novel signalling pathway that regulates haematopoietic stem cell emergence in the aorta-gonad-mesonephros.

Mon May 04 00:00:00 EDT 2015

Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Römer C,Engel O,Winek K,Hochmeister S,Zhang T,Royl G,Klehmet J,Dirnagl U,Meisel C,Meisel A

Wed May 20 00:00:00 EDT 2015

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis.

Mediators of inflammation

Hou YC,Wu JM,Wang MY,Wu MH,Chen KY,Yeh SL,Lin MT

17-0031 was used in Flow cytometry/Cell sorting to demonstrate that appropriate dosage of APS reduces Treg populations and elicits a more balanced Th1/Th2 response to attenuate sepsis-induced immunosuppression.

Tue Sep 20 00:00:00 EDT 2016

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

Control of the Survival and Growth of Human Glioblastoma Grafted Into the Spinal Cord of Mice by Taking Advantage of Immunorejection.

Cell transplantation

Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M

17-0031 was used in Flow cytometry/Cell sorting to establish a glioblastoma multiforme xenograft model mouse.

Mon Apr 11 00:00:00 EDT 2016

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Cell reports

Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8⁺ T-cell responses and immune memory.

Oncoimmunology

Wu J,Waxman DJ

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.

PloS one

Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue May 24 00:00:00 EDT 2016

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.

BMC cancer

Gillgrass AE,Chew MV,Krneta T,Ashkar AA

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2015

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.

Journal of translational medicine

Ghonim MA,Pyakurel K,Ibba SV,Al-Khami AA,Wang J,Rodriguez P,Rady HF,El-Bahrawy AH,Lammi MR,Mansy MS,Al-Ghareeb K,Ramsay A,Ochoa A,Naura AS,Boulares AH

17-0031 was used in Flow cytometry/Cell sorting to examine the efficacy of olaparib in blocking established allergic airway inflammation and hyperresponsiveness similar to those observed in human asthma in animal models of the disease.

Tue Jul 14 00:00:00 EDT 2015

Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.

PloS one

Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA

17-0031 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.

Tue Apr 19 00:00:00 EDT 2016

Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation.

PloS one

Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M

17-0031 was used in Flow cytometry/Cell sorting to determine the feasibility of ablation of the tumors formed after hiPSC-NS/PC transplantation through immunoregulation.

Tue Dec 01 00:00:00 EST 2015

Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization.

Toxins

Xu SX,Kasper KJ,Zeppa JJ,McCormick JK

17-0031 was used in Flow cytometry/Cell sorting to investigate how staphylococcal SAgs may be involved in regulating bacterial densities during nasal colonisation.

Fri May 22 00:00:00 EDT 2015

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.

Oncoimmunology

Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T

17-0031 was used in Flow cytometry/Cell sorting to demonstrate that sunitinib can create a favourable microenvironment depleted of MDSCs, and act synergistically with a cancer vaccine, resulting in enhanced levels of active tumor-antigen specific CTLs.

Sun Mar 01 00:00:00 EST 2015

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.

Science translational medicine

Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.

PLoS pathogens

Kasper KJ,Zeppa JJ,Wakabayashi AT,Xu SX,Mazzuca DM,Welch I,Baroja ML,Kotb M,Cairns E,Cleary PP,Haeryfar SM,McCormick JK

17-0031 was used in Flow cytometry/Cell sorting to study how secreted superantigens contribute to the fitness and evolution of S. pyogenes.

Thu May 01 00:00:00 EDT 2014

Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion.

European journal of immunology

Larsen J,Dall M,Antvorskov JC,Weile C,Engkilde K,Josefsen K,Buschard K

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.

European journal of immunology

Bakocevic N,Claser C,Yoshikawa S,Jones LA,Chew S,Goh CC,Malleret B,Larbi A,Ginhoux F,de Lafaille MC,Karasuyama H,Renia L,Ng LG

17-0031 was used in Flow cytometry/Cell sorting to study the CD41 expression within basophils from the blood during both steady state and malarial inections within mice.

Sun Jun 01 00:00:00 EDT 2014

Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

Journal of immunology (Baltimore, Md. : 1950)

Bökers S,Urbat A,Daniel C,Amann K,Smith KG,Espéli M,Nitschke L

17-0031 was used in Flow cytometry/Cell sorting to study how loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis.

Tue Apr 01 00:00:00 EDT 2014

Functional effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.

Journal of immunology (Baltimore, Md. : 1950)

Gao P,Zhou Y,Xian L,Li C,Xu T,Plunkett B,Huang SK,Wan M,Cao X

17-0031 was used in Flow cytometry/Cell sorting to investigate the role of TGF-β1 in mesenchymal stem cell migration in allergic asthma.

Thu May 15 00:00:00 EDT 2014

T Cell factor 1 represses CD8+ effector T cell formation and function.

Journal of immunology (Baltimore, Md. : 1950)

Tiemessen MM,Baert MR,Kok L,van Eggermond MC,van den Elsen PJ,Arens R,Staal FJ

17-0031 was used in Flow cytometry/Cell sorting to explore the role of the Wnt-responsive transcription factor T cell factor 1 in the initial phases of CD8(+) T effector cell formation.

Mon Dec 01 00:00:00 EST 2014

A novel pro-angiogenic function for interferon-γ-secreting natural killer cells.

Investigative ophthalmology & visual science

Lee H,Schlereth SL,Park EY,Emami-Naeini P,Chauhan SK,Dana R

17-0031 was used in Flow cytometry/Cell sorting to explore the function of natural killer cells in inflammatory angiogenesis in mice.

Fri May 02 00:00:00 EDT 2014

Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo.

Infection and immunity

Xu SX,Gilmore KJ,Szabo PA,Zeppa JJ,Baroja ML,Haeryfar SM,McCormick JK

17-0031 was used in Flow cytometry/Cell sorting to study host immune responses to superantigen toxins released by S. aureus.

Mon Sep 01 00:00:00 EDT 2014

Role of IL-17 and TGF-β in peritoneal adhesion formation after surgical trauma.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Wang G,Wu K,Li W,Zhao E,Shi L,Wang J,Shuai X,Cai K,Lu X,Tao K,Wang G

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2015

Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries.

BioMed research international

Wang H,Yang YL,Zhang H,Yan H,Wu XJ,Zhang CZ

17-0031 was used in Flow cytometry/Cell sorting to examine if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression.

Mon Mar 30 00:00:00 EDT 2015

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.

PloS one

Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2015

Autophagy is a critical regulator of memory CD8(+) T cell formation.

eLife

Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK

17-0031 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.

Tue Nov 11 00:00:00 EST 2014

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Blood

Franke K,Kalucka J,Mamlouk S,Singh RP,Muschter A,Weidemann A,Iyengar V,Jahn S,Wieczorek K,Geiger K,Muders M,Sykes AM,Poitz DM,Ripich T,Otto T,Bergmann S,Breier G,Baretton G,Fong GH,Greaves DR,Bornstein S,Chavakis T,Fandrey J,Gassmann M,Wielockx B

17-0031 was used in Flow cytometry/Cell sorting to study the regulatory effects of oxygen-sensitive prolyl hydroxylases on the process of erythropoiesis.

Thu Feb 21 00:00:00 EST 2013

Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.

Arteriosclerosis, thrombosis, and vascular biology

Ait-Oufella H,Herbin O,Lahoute C,Coatrieux C,Loyer X,Joffre J,Laurans L,Ramkhelawon B,Blanc-Brude O,Karabina S,Girard CA,Payré C,Yamamoto K,Binder CJ,Murakami M,Tedgui A,Lambeau G,Mallat Z

17-0031 was used in Flow cytometry/Cell sorting to study the proatherogenic properties of PLA2G10, a type of several secreted phospholipase A2.

Fri Mar 01 00:00:00 EST 2013

B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response.

PLoS pathogens

Kozakiewicz L,Chen Y,Xu J,Wang Y,Dunussi-Joannopoulos K,Ou Q,Flynn JL,Porcelli SA,Jacobs WR,Chan J

17-0031 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which B cells regulate the host neutrophilic response upon exposure to mycobacteria, showing that they do this by modulating the interleukin-17 response.

Tue Feb 18 00:00:00 EST 2014

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.

Development (Cambridge, England)

Tober J,Yzaguirre AD,Piwarzyk E,Speck NA

17-0031 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.

Sun Sep 01 00:00:00 EDT 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis.

Clinical and experimental immunology

Wang J,Shan Y,Jiang Z,Feng J,Li C,Ma L,Jiang Y

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Chen Z,Kim SJ,Chamberlain ND,Pickens SR,Volin MV,Volkov S,Arami S,Christman JW,Prabhakar BS,Swedler W,Mehta A,Sweiss N,Shahrara S

17-0031 was used in Flow cytometry/Cell sorting to study the role of IL7/IL7R in myeloid cells of rheumatoid arthritis and collagen induced arthritis.

Wed May 15 00:00:00 EDT 2013

Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.

Journal of immunology (Baltimore, Md. : 1950)

Tsuboi K,Hirakawa J,Seki E,Imai Y,Yamaguchi Y,Fukuda M,Kawashima H

17-0031 was used in Flow cytometry/Cell sorting to suggest that chemokine presentation by heparan sulfate on the surface of high endothelial venules facilitates lymphocyte homing.

Mon Jul 01 00:00:00 EDT 2013

n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.

The Journal of nutrition

Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS

17-0031 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.

Sun Sep 01 00:00:00 EDT 2013

Ontogeny and localization of the cells produce IL-2 in healthy animals.

Cytokine

Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M

17-0031 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..

Fri Mar 01 00:00:00 EST 2013

Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice.

Journal of cancer science & therapy

Zheng D,Chen H,Bartee MY,Williams J,Davids JA,Lomas DA,McFadden G,Lucas AR

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Aug 19 00:00:00 EDT 2013

Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

PloS one

Imai T,Koyanagi N,Ogawa R,Shindo K,Suenaga T,Sato A,Arii J,Kato A,Kiyono H,Arase H,Kawaguchi Y

17-0031 was used in Flow cytometry/Cell sorting to reveal that Us3 kinase activity is required for influencing cell surface expression for evasion of HSV-1-specific CD8(+) T cells.

Tue Apr 15 00:00:00 EDT 2014

Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma.

Respiratory research

Kan-o K,Matsunaga Y,Fukuyama S,Moriwaki A,Hirai-Kitajima H,Yokomizo T,Aritake K,Urade Y,Nakanishi Y,Inoue H,Matsumoto K

17-0031 was used in Flow cytometry/Cell sorting to determine the role of mast cells in the virus-associated pathogenesis of asthma.

Mon Mar 04 00:00:00 EST 2013

Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.

PloS one

Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H

17-0031 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.

Tue Sep 17 00:00:00 EDT 2013

Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation.

PloS one

Ma S,Richardson JA,Bitmansour A,Solberg TD,Pidikiti R,Song K,Stojadinovic S,Vitetta ES,Meyer JJ

17-0031 was used in Flow cytometry/Cell sorting to investigate the effects of partial depletion of regulatory T cells alongside ionizing radiation on inflammation and tissue injury in mice.

Mon Jul 29 00:00:00 EDT 2013

Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.

Immunity

Roberts NA,White AJ,Jenkinson WE,Turchinovich G,Nakamura K,Withers DR,McConnell FM,Desanti GE,Benezech C,Parnell SM,Cunningham AF,Paolino M,Penninger JM,Simon AK,Nitta T,Ohigashi I,Takahama Y,Caamano JH,Hayday AC,Lane PJ,Jenkinson EJ,Anderson G

17-0031 was used in Flow cytometry/Cell sorting to study the temporal development of Vγ5(+) γδ T cells during thymus medulla formation.

Fri Mar 23 00:00:00 EDT 2012

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.

Journal of autoimmunity

Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A

17-0031 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.

Wed Feb 01 00:00:00 EST 2012

Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model.

Journal of lipid research

Fan YY,Monk JM,Hou TY,Callway E,Vincent L,Weeks B,Yang P,Chapkin RS

17-0031 was used in Flow cytometry/Cell sorting to determine the utility of antagonising tissue arachidonic acid (AA) levels as a novel approach to suppress AA-derived eicosanoids.

Sun Jul 01 00:00:00 EDT 2012

Pulmonary T cell activation in response to chronic particulate air pollution.

American journal of physiology. Lung cellular and molecular physiology

Deiuliis JA,Kampfrath T,Zhong J,Oghumu S,Maiseyeu A,Chen LC,Sun Q,Satoskar AR,Rajagopalan S

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Feb 15 00:00:00 EST 2012

The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope.

Journal of immunology (Baltimore, Md. : 1950)

de Souza MS,Ratto-Kim S,Chuenarom W,Schuetz A,Chantakulkij S,Nuntapinit B,Valencia-Micolta A,Thelian D,Nitayaphan S,Pitisuttithum P,Paris RM,Kaewkungwal J,Michael NL,Rerks-Ngarm S,Mathieson B,Marovich M,Currier JR,Kim JH

17-0031 was used in Flow cytometry/Cell sorting to reveal T cell response of HIV-1 vaccine recipients was directed to a particular region of viral envelope.

Tue May 15 00:00:00 EDT 2012

TLR9 and MyD88 are crucial for the development of protective immunity to malaria.

Journal of immunology (Baltimore, Md. : 1950)

Gowda NM,Wu X,Gowda DC

17-0031 was used in Flow cytometry/Cell sorting to investigate TLR9 and MyD88 regulation of pro/anti-inflammatory cytokines in mice infected with Plasmodium yoelii.

Tue May 15 00:00:00 EDT 2012

Effect of the poly(ethylene glycol) (PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration.

Molecular pharmaceutics

Zhan X,Tran KK,Shen H

17-0031 was used in Flow cytometry/Cell sorting to study the effect of PEGylation on the lymphatic trafficking and accumulation of particles in draining lymph nodes.

Mon Dec 03 00:00:00 EST 2012

Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

American journal of physiology. Gastrointestinal and liver physiology

Ernst PB,Erickson LD,Loo WM,Scott KG,Wiznerowicz EB,Brown CC,Torres-Velez FJ,Alam MS,Black SG,McDuffie M,Feldman SH,Wallace JL,McKnight GW,Padol IT,Hunt RH,Tung KS

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response.

Infection and immunity

Frank KM,Zhou T,Moreno-Vinasco L,Hollett B,Garcia JG,Bubeck Wardenburg J

17-0031 was used in Flow cytometry/Cell sorting to evaluate the transcriptomic response to Hla-secreting staphylococci infection in humans.

Sat Sep 01 00:00:00 EDT 2012

MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.

Infection and immunity

Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S

17-0031 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.

Sun Jan 01 00:00:00 EST 2012

Species-specific activity of glycolipid ligands for invariant NKT cells.

Chembiochem : a European journal of chemical biology

Dangerfield EM,Cheng JM,Knight DA,Weinkove R,Dunbar PR,Hermans IF,Timmer MS,Stocker BL

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Jun 18 00:00:00 EDT 2012

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.

The Journal of biological chemistry

Badeaux AI,Yang Y,Cardenas K,Vemulapalli V,Chen K,Kusewitt D,Richie E,Li W,Bedford MT

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Jan 02 00:00:00 EST 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.

Journal of the American Heart Association

Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M

17-0031 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.

Mon Oct 01 00:00:00 EDT 2012

Increased synapse formation obtained by T cell epitopes containing a CxxC motif in flanking residues convert CD4+ T cells into cytolytic effectors.

PloS one

Carlier VA,VanderElst L,Janssens W,Jacquemin MG,Saint-Remy JM

17-0031 was used in Flow cytometry/Cell sorting to investigate the conditions under which cytolytic CD4+ T cells are elicited.

Tue Apr 02 00:00:00 EDT 2013

Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses.

The Journal of experimental medicine

Ohmichi Y,Hirakawa J,Imai Y,Fukuda M,Kawashima H

17-0031 was used in Flow cytometry/Cell sorting to demonstrate that PNAd is essential for lymphocyte homing to NALT and nasal allergic responses.

Mon May 09 00:00:00 EDT 2011

Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysis.

Nature protocols

Cato MH,Yau IW,Rickert RC

17-0031 was used in Magnetic cell separation to provide a protocol for a novel magnetic bead separation scheme for the purification of mature B cells for biochemical assessment.

Thu Jun 09 00:00:00 EDT 2011

Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.

Biology of reproduction

Meng J,Greenlee AR,Taub CJ,Braun RE

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2011

Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.

The Journal of surgical research

Schneider DF,Palmer JL,Tulley JM,Kovacs EJ,Gamelli RL,Faunce DE

17-0031 was used in Flow cytometry/Cell sorting to explore the effects of purposefully inhibiting natural killer T cell activation on the response to injury.

Tue Nov 01 00:00:00 EDT 2011

An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes.

Journal of immunological methods

Brubaker AL,Schneider DF,Palmer JL,Faunce DE,Kovacs EJ

17-0031 was used in Flow cytometry/Cell sorting to develop a method for preparing wound cell suspensions for further study.

Fri Oct 28 00:00:00 EDT 2011

T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.

PloS one

Moro H,Otero DC,Tanabe Y,David M

17-0031 was used in Flow cytometry/Cell sorting to demonstrate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells.

Fri Feb 03 00:00:00 EST 2012

Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.

PloS one

Hasenberg M,Köhler A,Bonifatius S,Borucki K,Riek-Burchardt M,Achilles J,Männ L,Baumgart K,Schraven B,Gunzer M

17-0031 was used in Flow cytometry/Cell sorting to develop a novel protocol for isolating pure polymorphonuclear neutrophils from murine bone marrow.

Wed Feb 23 00:00:00 EST 2011

Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice.

American journal of respiratory and critical care medicine

Motz GT,Eppert BL,Wesselkamper SC,Flury JL,Borchers MT

17-0031 was used in Flow cytometry/Cell sorting to determine whether T cells are pathogenic in a chronic cigarette smoke-induced mouse model of chronic obstructive pulmonary disease.

Tue Jun 01 00:00:00 EDT 2010

TLR8 deficiency leads to autoimmunity in mice.

The Journal of clinical investigation

Demaria O,Pagni PP,Traub S,de Gassart A,Branzk N,Murphy AJ,Valenzuela DM,Yancopoulos GD,Flavell RA,Alexopoulou L

17-0031 was used in Flow cytometry/Cell sorting to explore the relationship between TLR8 and TLR7 and autoimmunity in mice.

Fri Oct 01 00:00:00 EDT 2010

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.

Obesity (Silver Spring, Md.)

Strissel KJ,DeFuria J,Shaul ME,Bennett G,Greenberg AS,Obin MS

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2010

BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Smith IA,Knezevic BR,Ammann JU,Rhodes DA,Aw D,Palmer DB,Mather IH,Trowsdale J

17-0031 was used in Flow cytometry/Cell sorting to confirm a coinhibitory role for mouse BTN1A1.

Thu Apr 01 00:00:00 EDT 2010

Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.

Journal of immunology (Baltimore, Md. : 1950)

Motz GT,Eppert BL,Wortham BW,Amos-Kroohs RM,Flury JL,Wesselkamper SC,Borchers MT

17-0031 was used in Flow cytometry/Cell sorting to demonstrate an entirely novel mechanism of NK cell activation resulting from chronic cigarette smoke exposure.

Thu Apr 15 00:00:00 EDT 2010

Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.

Mediators of inflammation

Gomez CR,Karavitis J,Palmer JL,Faunce DE,Ramirez L,Nomellini V,Kovacs EJ

17-0031 was used in Flow cytometry/Cell sorting to demonstrate in vitro that Interleukin-6 regulates age-related defects in splenic macrophages through alteration of proinflammatory cytokines.

Thu Nov 04 00:00:00 EDT 2010

Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis.

BMC microbiology

Karasova D,Sebkova A,Havlickova H,Sisak F,Volf J,Faldyna M,Ondrackova P,Kummer V,Rychlik I

17-0031 was used in Flow cytometry/Cell sorting to investigate the colonisation and early immune response of Balb/C mice to infection with Salmonella Enteritidis and isogenic pathogenicity island free mutants.

Fri Mar 12 00:00:00 EST 2010

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Gastroenterology

Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2009

Effect of polyI:C cotreatment on halothane-induced liver injury in mice.

Hepatology (Baltimore, Md.)

Cheng L,You Q,Yin H,Holt M,Franklin C,Ju C

17-0031 was used in Flow cytometry/Cell sorting to investigate the effect of viral infection on halothane-induced hepatotoxicity in mice using a viral RNA mimetic.

Thu Jan 01 00:00:00 EST 2009

Tracking epitope-specific T cells.

Nature protocols

Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2009

Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Zhou Q,Yan J,Putheti P,Wu Y,Sun X,Toxavidis V,Tigges J,Kassam N,Enjyoji K,Robson SC,Strom TB,Gao W

17-0031 was used in Flow cytometry/Cell sorting to study how besides Tregs, CD39 is also expressed on pre-existing memory T cells of Th1-, Th2- and Th17-types with heightened alloreactivity.

Thu Oct 01 00:00:00 EDT 2009

Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.

International immunology

Siegemund S,Schütze N,Schulz S,Wolk K,Nasilowska K,Straubinger RK,Sabat R,Alber G

17-0031 was used in Flow cytometry/Cell sorting to study whether IL-22 and IL-17A production is initiated early in response to S. Enteritidis, showing that early production of IL-22 was dependent on IL-23, however IL-17A was only partially IL-23-dependent.

Fri May 01 00:00:00 EDT 2009

Dynamics of lung macrophage activation in response to helminth infection.

Journal of leukocyte biology

Siracusa MC,Reece JJ,Urban JF,Scott AL

17-0031 was used in Flow cytometry/Cell sorting to characterise the surface molecules, gene expression, and cell function of macrophages isolated from lung tissue after helminth infection.

Mon Dec 01 00:00:00 EST 2008

Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.

The American journal of pathology

Gongora MC,Lob HE,Landmesser U,Guzik TJ,Martin WD,Ozumi K,Wall SM,Wilson DS,Murthy N,Gravanis M,Fukai T,Harrison DG

17-0031 was used in Flow cytometry/Cell sorting to study the role of acute SOD3 reduction in lung injury.

Wed Oct 01 00:00:00 EDT 2008

Unique receptor repertoire in mouse uterine NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F

17-0031-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.

Sat Nov 01 00:00:00 EDT 2008

p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.

PloS one

Cheng N,van de Wetering CI,Knudson CM

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2008

Tumor growth decreases NK and B cells as well as common lymphoid progenitor.

PloS one

Richards J,McNally B,Fang X,Caligiuri MA,Zheng P,Liu Y

17-0031 was used in Flow cytometry/Cell sorting to analyse the effects of tumour growth on lymphopoiesis in mice.

Thu Sep 11 00:00:00 EDT 2008

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.

Immunity

Fritz JH,Le Bourhis L,Sellge G,Magalhaes JG,Fsihi H,Kufer TA,Collins C,Viala J,Ferrero RL,Girardin SE,Philpott DJ

17-0031 was used in Flow cytometry/Cell sorting to examine the role of the Nod1 receptor in the generation of adaptive immune responses.

Sun Apr 01 00:00:00 EDT 2007

Dendritic cells prime natural killer cells by trans-presenting interleukin 15.

Immunity

Lucas M,Schachterle W,Oberle K,Aichele P,Diefenbach A

17-0031 was used in Flow cytometry/Cell sorting to study an in vivo role of dendritic cells for the priming of natural killer cells by trans-presenting interleukin 15.

Sun Apr 01 00:00:00 EDT 2007

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

Proceedings of the National Academy of Sciences of the United States of America

Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T

17-0031-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.

Tue Jan 30 00:00:00 EST 2007

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.

International journal of experimental pathology

DuPré SA,Redelman D,Hunter KW

Published figure using CD3e monoclonal antibody (Product # 17-0031-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2007

ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding.

Blood

Li Y,Brazzell J,Herrera A,Walcheck B

17-0031 was used in Flow cytometry/Cell sorting to investigate the role of Adam17 in L-selectin shedding by mature neutrophils, showing that deficiency by mature neutrophils has differential effects on L-selectin shedding.

Sun Oct 01 00:00:00 EDT 2006

Tumor growth impedes natural-killer-cell maturation in the bone marrow.

Blood

Richards JO,Chang X,Blaser BW,Caligiuri MA,Zheng P,Liu Y

17-0031 was used in Flow cytometry/Cell sorting to demonstrate that tumour growth can impede functional maturation of NK cells, most likely by interrupting the requisite IL-15 signalling pathway.

Sat Jul 01 00:00:00 EDT 2006

HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.

International journal of cancer

Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH

Thu Jun 01 00:00:00 EDT 2006

Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Proceedings of the National Academy of Sciences of the United States of America

Nakae S,Suto H,Kakurai M,Sedgwick JD,Tsai M,Galli SJ

17-0031 was used in Functional assays to investigate the mechanisms by which mast cells influence T cells in T cell-mediated disorders, showing that they enhance activation.

Tue May 03 00:00:00 EDT 2005

Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Krieg C,Han P,Stone R,Goularte OD,Kaye J

Tue Nov 15 00:00:00 EST 2005

CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.

Investigative ophthalmology & visual science

Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M

Sat Oct 01 00:00:00 EDT 2005

The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold.

The EMBO journal

Stoll R,Renner C,Zweckstetter M,Brüggert M,Ambrosius D,Palme S,Engh RA,Golob M,Breibach I,Buettner R,Voelter W,Holak TA,Bosserhoff AK

17-0031 was used in Flow cytometry/Cell sorting to investigate the role of MIA in metastasis, showing that it adopts an SH3 domain-like fold.

Thu Feb 01 00:00:00 EST 2001

Bioinformatics

Protein Aliases: CD247; CD247 antigen; CD3 antigen, zeta polypeptide; CD3 TCR complex; CD3-zeta/eta; CD3d; CD3e; CD3g; FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex

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Gene Aliases: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; Cd247; CD3; Cd3-eta; Cd3-zeta; Cd3d; Cd3e; CD3epsilon; Cd3g; Cd3h; Cd3z; Cd3zeta; Ctg-3; Ctg3; T3d; T3e; T3g; T3z; Tcrk; Tcrz

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UniProt ID: (Mouse) P24161, (Mouse) P04235, (Mouse) P22646, (Mouse) P11942

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Entrez Gene ID: (Mouse) 12503, (Mouse) 12500, (Mouse) 12501, (Mouse) 12502

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Function(s)

transmembrane signaling receptor activity protein binding identical protein binding protein heterodimerization activity signal transducer activity SH3 domain binding defense/immunity protein immunoglobulin receptor superfamily

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CD3e Monoclonal Antibody (145-2C11), APC, eBioscience™

CD3e Antibody (17-0031-82) in Flow

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17-0031-82

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