Invitrogen

CD3e Monoclonal Antibody (145-2C11), eBioscience™

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Antibody Testing Data (1)
Published Figures (93)

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CD3e Antibody (14-0031-82) in Flow

Staining of C57Bl/6 splenocytes with Armenian Hamster IgG Isotype Control Purified (Product # 14-4888-81) (open histogram) or Anti-Mouse CD3e Purified (filled histogram) followed by Anti-Armenian Hamster IgG FITC (Product # 11-4111). Total viable cells were used for analysis.

CD3e Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

CD3e Antibody in Immunocytochemistry (ICC/IF)

CD3e Antibody in Western Blot, Immunocytochemistry, Immunoprecipitation (WB, ICC/IF, IP)

CD3e Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

CD3e Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD3e Antibody in Immunohistochemistry (IHC)

CD3e Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

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Product Details

14-0031-82

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 23 publications 23 publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

View 9 publications 9 publications

Flow Cytometry (Flow)

0.5 µg/test

View 315 publications 315 publications

ELISA (ELISA)

View 6 publications 6 publications

Immunoprecipitation (IP)

Assay-Dependent

View 1 publication 1 publication

Functional Assay (Functional)

Assay-Dependent

View 114 publications 114 publications

Radioimmune Assays (RIA)

View 1 publication 1 publication

Blocking Assay (BLOCK)

View 1 publication 1 publication

T-Cell Activation (TCA)

View 6 publications 6 publications

In vitro Assay (IV)

View 22 publications 22 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Armenian hamster / IgG

Class

Monoclonal

Type

Antibody

Clone

145-2C11

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_467049

Product Specific Information

Description: The 145-2C11 monoclonal antibody reacts with mouse CD3e, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits, gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Binding of 145-2C11 to TCR initiates the intracellular biochemical pathway resulting in cellular activation, proliferation, and apoptosis depending on specific conditions utilized. 145-2C11 is commonly used as a phenotypic marker for mouse T cells.

Applications Reported: The 145-2C11 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunoblotting (WB), and immunohistochemical staining of frozen tissue sections. It has also been reported in cell activation and cell depletion. (Please use Functional Grade purified 145-2C11, Product # 16-0031, in functional assays).

Applications Tested: The 145-2C11 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Purity: Greater than 90%, as determined by SDS-PAGE.

Aggregation: Less than 10%, as determined by HPLC.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy.

NPJ vaccines

Teymournejad O,Li Z,Beesetty P,Yang C,Montgomery CP

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Jan 24 00:00:00 EST 2023

NCR negative group 3 innate lymphoid cell (NCR^- ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.

Immunity, inflammation and disease

Chu S,Ma L,Yang X,Xiao B,Liang Y,Zheng S,Li L

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.

Diabetes

Luan D,Dadpey B,Zaid J,Bridge-Comer PE,DeLuca JH,Xia W,Castle J,Reilly SM

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Naringenin Improves Ovalbumin-Induced Allergic Asthma in Rats through Antioxidant and Anti-Inflammatory Effects.

Evidence-based complementary and alternative medicine : eCAM

Jasemi SV,Khazaei H,Fakhri S,Mohammadi-Noori E,Farzaei MH

14-0031-82 was used in Immunohistochemistry to demonstrate that naringenin dramatically improved ovalbumin-induced allergic asthma through its specific antioxidant and anti-inflammatory characteristics.

Sat Apr 23 00:00:00 EDT 2022

Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe Mice.

Frontiers in pharmacology

Manickam V,Dhawan UK,Singh D,Gupta M,Subramanian M

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Sat Jul 16 00:00:00 EDT 2022

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.

Cell reports

Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Tue Mar 22 00:00:00 EDT 2022

Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis.

FEBS open bio

No authors listed

14-0031 was used in Flow cytometry/Cell sorting to suggest that Parecoxib inhibits the inflammatory response and has protective effects against sepsis in mice, and may have potential as a novel therapeutic method for treating sepsis.

Sat Jan 01 00:00:00 EST 2022

Histone deficiency and accelerated replication stress in T cell aging.

The Journal of clinical investigation

Kim C,Jin J,Ye Z,Jadhav RR,Gustafson CE,Hu B,Cao W,Tian L,Weyand CM,Goronzy JJ

14-0031-82 was used in Flow Cytometry to show that naive T cells from older individuals as well as miR-181ab1-deficient murine T cells develop excessive replication stress after activation due to reduced histone expression and delayed S-phase cell cycle progression.

Tue Jun 01 00:00:00 EDT 2021

Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.

Proceedings of the National Academy of Sciences of the United States of America

McCorkell KA,Jayachandran N,Cully MD,Freund-Brown J,Weinkopff T,Monslow J,Hu Y,Puré E,Freedman BD,Alvarez JI,Cancro MP,May MJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Tue Nov 30 00:00:00 EST 2021

The capacity of CD4⁺ Vγ9Vδ2 T cells to kill cancer cells correlates with co-expression of CD56.

Cytotherapy

Holmen Olofsson G,Pedersen SR,Aehnlich P,Svane IM,Idorn M,Thor Straten P

14-0031-82 was used in Functional assay to show that CD4+ Vγ9Vδ2 T cells comprise 0.1-7% of peripheral blood Vγ9Vδ2 T cells.

Thu Jul 01 00:00:00 EDT 2021

A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.

Journal of cellular and molecular medicine

Wei DP,Li DD,Gu AQ,Ji WH,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.

The European journal of neuroscience

Frühauf M,Zeitschel U,Höfling C,Ullm F,Rabiger FV,Alber G,Pompe T,Müller U,Roßner S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.

The Journal of biological chemistry

McAndrews KM,Che SPY,LeBleu VS,Kalluri R

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Aug 20 00:00:00 EDT 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Sat Jan 30 00:00:00 EST 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Sat Jan 30 00:00:00 EST 2021

Obesity results in adipose tissue T cell exhaustion.

JCI insight

Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Nature communications

Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Jul 14 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

PIR-B Regulates CD4⁺ IL17a⁺ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses.

Cellular and molecular gastroenterology and hepatology

Uddin J,Tomar S,Sharma A,Waggoner L,Ganesan V,Marella S,Yang Y,Noah T,Vanoni S,Patterson A,Zeng C,Foster PS,Newberry R,Bishu S,Kao JY,Rosen MJ,Denson L,King PD,Hoebe K,Divanovic S,Munitz A,Hogan SP

14-0031-82 was used in In vivo experiments to show an intrinsic role for PIR-B/LILRB3 in the regulation of CD4+ IL17a+ T-cell pathogenic memory responses.

Fri Mar 25 00:00:00 EDT 2022

TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells.

Cellular & molecular immunology

Xie X,Zhu L,Jie Z,Li Y,Gu M,Zhou X,Wang H,Chang JH,Ko CJ,Cheng X,Sun SC

14-0031-82 was used in Flow cytometry/Cell sorting to show that TNF receptor-associated factor 2 (TRAF2) maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against infections.

Wed Sep 01 00:00:00 EDT 2021

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.

iScience

Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.

Journal for immunotherapy of cancer

Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C

14-0031-82 was used in Immunohistochemistry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.

Tue Jun 01 00:00:00 EDT 2021

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.

Cell

Yao M,Ventura PB,Jiang Y,Rodriguez FJ,Wang L,Perry JSA,Yang Y,Wahl K,Crittenden RB,Bennett ML,Qi L,Gong CC,Li XN,Barres BA,Bender TP,Ravichandran KS,Janes KA,Eberhart CG,Zong H

14-0031 was used in Flow cytometry/Cell sorting to reveal an evolutionary process that produces a multi-lateral network within the TME of medulloblastoma: a fraction of tumor cells trans-differentiate into TuAstrocytes, which, in turn, produce IL-4 that stimulates microglia to produce IGF1 to promote tumor progression.

Thu Feb 06 00:00:00 EST 2020

JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.

Cell death and differentiation

Simula L,Corrado M,Accordi B,Di Rita A,Nazio F,Antonucci Y,Di Daniele A,Caicci F,Caruana I,Soriano ME,Pigazzi M,Locatelli F,Cecconi F,Campello S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Functional assay

Thu Oct 01 00:00:00 EDT 2020

JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.

Cell death and differentiation

Simula L,Corrado M,Accordi B,Di Rita A,Nazio F,Antonucci Y,Di Daniele A,Caicci F,Caruana I,Soriano ME,Pigazzi M,Locatelli F,Cecconi F,Campello S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Functional assay

Thu Oct 01 00:00:00 EDT 2020

Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells.

Cancer immunology research

Wijewarnasuriya D,Bebernitz C,Lopez AV,Rafiq S,Brentjens RJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation.

Mucosal immunology

Ligon MM,Wang C,DeJong EN,Schulz C,Bowdish DME,Mysorekar IU

14-0031 was used in Immunohistochemistry-immunofluorescence to indicate that chronic, age-associated inflammation underlies a fundamental alteration to the bladder and establishes a resource for further investigation of the bladder immune system in homeostasis, aging, and disease.

Sun Nov 01 00:00:00 EDT 2020

Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects.

Blood advances

Estupiñán HY,Bouderlique T,He C,Berglöf A,Gupta D,Saher O,Daza Cruz MÁ,Peña-Perez L,Yu L,Zain R,Karlsson MCI,Månsson R,Smith CIE

14-0031-82 was used in Flow Cytometry to generate mice carrying a mutated BTK to serve as a tool to identify novel therapeutic targets and to discover off-target effects.

Tue Jun 09 00:00:00 EDT 2020

Antitumor Effect and Immune Response of Nanosecond Pulsed Electric Fields in Pancreatic Cancer.

Frontiers in oncology

Zhao J,Chen S,Zhu L,Zhang L,Liu J,Xu D,Tian G,Jiang T

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

Secreted Phospholipase A₂ Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.

Journal of immunology (Baltimore, Md. : 1950)

Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS

14-0031-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.

Mon Jun 15 00:00:00 EDT 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4⁺ CD25⁺ regulatory T cells.

Journal of cellular and molecular medicine

Ge Y,Huang M,Wu Y,Dong N,Yao YM

14-0031-82 was used in Flow Cytometry to investigate the role of IL-38 in mediating the activity of CD4+ CD25+ Tregs during sepsis.

Wed Jan 01 00:00:00 EST 2020

Exosome miR-27a-3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma.

Thoracic cancer

Fan X,Wang J,Qin T,Zhang Y,Liu W,Jiang K,Huang D

14-0031 was used in Flow cytometry/Cell sorting to determine that dipocyte-derived exo-miR-27a-3p could alter the tumor microenvironment by inhibiting ICOS+ T cell proliferation and IFN-gamma secretion in vitro.

Mon Jun 01 00:00:00 EDT 2020

Impact of S1P Mimetics on Mesenteric Ischemia/Reperfusion Injury.

Pharmaceuticals (Basel, Switzerland)

Potì F,Giorgio C,Zini I,Nofer JR,Vivo V,Palese S,Ballabeni V,Barocelli E,Bertoni S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Oct 09 00:00:00 EDT 2020

Optimization of Organotypic Cultures of Mouse Spleen for Staining and Functional Assays.

Frontiers in immunology

Finetti F,Capitani N,Manganaro N,Tatangelo V,Libonati F,Panattoni G,Calaresu I,Ballerini L,Baldari CT,Patrussi L

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunocytochemistry

Mon Mar 08 00:00:00 EST 2021

Optimization of Organotypic Cultures of Mouse Spleen for Staining and Functional Assays.

Frontiers in immunology

Finetti F,Capitani N,Manganaro N,Tatangelo V,Libonati F,Panattoni G,Calaresu I,Ballerini L,Baldari CT,Patrussi L

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunocytochemistry

Mon Mar 08 00:00:00 EST 2021

CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.

FEBS open bio

Liu Y,Gao Y,Hao H,Hou T

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

IDO1⁺ Paneth cells promote immune escape of colorectal cancer.

Communications biology

Pflügler S,Svinka J,Scharf I,Crncec I,Filipits M,Charoentong P,Tschurtschenthaler M,Kenner L,Awad M,Stift J,Schernthanner M,Bischl R,Herndler-Brandstetter D,Glitzner E,Moll HP,Casanova E,Timelthaler G,Sibilia M,Gnant M,Lax S,Thaler J,Müller M,Strobl B,Mohr T,Kaser A,Trajanoski Z,Heller G,Eferl R

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.

Cell reports

Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Jun 17 00:00:00 EDT 2021

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.

Cell reports

Piao W,Xiong Y,Li L,Saxena V,Smith KD,Hippen KL,Paluskievicz C,Willsonshirkey M,Blazar BR,Abdi R,Bromberg JS

14-0031 was used in Flow cytometry/Cell sorting to demonstrate the role of regulatory T cells in enhancing leukocyte migration through endothelial barriers.

Tue Jan 28 00:00:00 EST 2020

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.

Oncoimmunology

Cervera-Carrascon V,Quixabeira DCA,Santos JM,Havunen R,Zafar S,Hemminki O,Heiniö C,Munaro E,Siurala M,Sorsa S,Mirtti T,Järvinen P,Mildh M,Nisen H,Rannikko A,Anttila M,Kanerva A,Hemminki A

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

The effect of smoking on chronic inflammation, immune function and blood cell composition.

Scientific reports

Elisia I,Lam V,Cho B,Hay M,Li MY,Yeung M,Bu L,Jia W,Norton N,Lam S,Krystal G

14-0031-82 was used in Functional assay to evaluate the effects of smoking on inflammatory markers, innate and adaptive immune responses to bacterial and viral challenges and blood cell composition.

Tue Nov 10 00:00:00 EST 2020

Overproduction of IL-2 by Cbl-b deficient CD4⁺ T cells provides resistance against regulatory T cells.

Oncoimmunology

Han S,Chung DC,St Paul M,Liu ZQ,Garcia-Batres C,Elford AR,Tran CW,Chapatte L,Ohashi PS

14-0031 was used in Functional assays to investigate the role of Cbl-b, an E3 ubiquitin ligase, in establishing resistance to Treg-mediated suppression.

Wed Jul 28 00:00:00 EDT 2021

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma.

Cancers

Shirley SA,Lundberg CG,Heller R

14-0031 was used in Immunohistochemistry to demonstrate that the level of IL-15 expressed in tumors after GET is an important determinant of the therapeutic outcome.

Wed Oct 21 00:00:00 EDT 2020

IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A⁺Foxp3⁺ Cells During Mucosal Infection and Is Dysregulated With Aging.

Frontiers in immunology

Bhaskaran N,Faddoul F,Paes da Silva A,Jayaraman S,Schneider E,Mamileti P,Weinberg A,Pandiyan P

14-0031-82 was used in Flow Cytometry, In vitro Assay to identify IL-1β/MyD88/Treg axis as a new component that modulates inflammatory responses in oral mucosa.

Mon Jun 28 00:00:00 EDT 2021

IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A⁺Foxp3⁺ Cells During Mucosal Infection and Is Dysregulated With Aging.

Frontiers in immunology

Bhaskaran N,Faddoul F,Paes da Silva A,Jayaraman S,Schneider E,Mamileti P,Weinberg A,Pandiyan P

14-0031-82 was used in Flow Cytometry, In vitro Assay to identify IL-1β/MyD88/Treg axis as a new component that modulates inflammatory responses in oral mucosa.

Mon Jun 28 00:00:00 EDT 2021

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Jun 19 00:00:00 EDT 2020

Novel CD11b⁺Gr-1⁺Sca-1⁺ myeloid cells drive mortality in bacterial infection.

Science advances

Park MY,Kim HS,Lee HY,Zabel BA,Bae YS

14-0031-82 was used in Flow Cytometry to find a previously unidentified pathogenic CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus.

Wed Jan 01 00:00:00 EST 2020

Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.

Journal for immunotherapy of cancer

Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG

14-0031-82 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.

Sun Nov 01 00:00:00 EDT 2020

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.

Nature communications

von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS

14-0031-86 was used in Immunohistochemistry (Frozen) to show stimulation of glioma cell phagocytosis by blockage of anti-phagocytosis molecule CD47 is an ineffective process.

Fri Mar 20 00:00:00 EDT 2020

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.

Blood

Koehn BH,Saha A,McDonald-Hyman C,Loschi M,Thangavelu G,Ma L,Zaiken M,Dysthe J,Krepps W,Panthera J,Hippen K,Jameson SC,Miller JS,Cooper MA,Farady CJ,Iwawaki T,Ting JP,Serody JS,Murphy WJ,Hill GR,Murray PJ,Bronte V,Munn DH,Zeiser R,Blazar BR

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that conditioning regimen-induced adenosine triphosphate (ATP) release is a primary driver of myeloid-derived suppressor cells(MDSC) dysfunction through ATP receptor (P2x7R) engagement and NLR pyrin family domain 3 (NLRP3) inflammasome activation.

Thu Nov 07 00:00:00 EST 2019

In drug-induced, immune-mediated hepatitis, interleukin-33 reduces hepatitis and improves survival independently and as a consequence of FoxP3+ T-cell activity.

Cellular & molecular immunology

Cottagiri M,Nyandjo M,Stephens M,Mantilla JJ,Saito H,Mackay IR,Rose NR,Njoku DB

14-0031-82 was used in Flow Cytometry to suggest that, in anesthetic, immune-mediated hepatitis, IL-33 does not regulate the CD4+ T-cell proliferation that initiates hepatitis, but IL-33, likely independent of ST2, reduces hepatitis via upregulation of Foxp3+CD4+CD25+ T cells.

Thu Aug 01 00:00:00 EDT 2019

USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance.

The Journal of clinical investigation

Zhang Y,Liu RB,Cao Q,Fan KQ,Huang LJ,Yu JS,Gao ZJ,Huang T,Zhong JY,Mao XT,Wang F,Xiao P,Zhao Y,Feng XH,Li YY,Jin J

14-0031 was used in Flow cytometry/Cell sorting to study the mechanism of calcineurin activity regulation and a novel immunosuppressive drug target for the treatment of autoimmune diseases.

Tue May 28 00:00:00 EDT 2019

In the absence of natural killer cell activation donor-specific antibody mediates chronic, but not acute, kidney allograft rejection.

Kidney international

Yagisawa T,Tanaka T,Miyairi S,Tanabe K,Dvorina N,Yokoyama WM,Valujskikh A,Baldwin WM,Fairchild RL

14-0031-82 was used in Flow Cytometry to study the consequence of high donor-specific antibody titers on kidney graft outcomes in the presence or absence of natural killer cell activation within the graft.

Fri Feb 01 00:00:00 EST 2019

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

The Journal of experimental medicine

Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S

14-0031 was used in Flow cytometry/Cell sorting to solve a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I-restricted Ly49 receptors.

Mon Aug 05 00:00:00 EDT 2019

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.

The Journal of experimental medicine

Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR

14-0031-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.

Mon Apr 01 00:00:00 EDT 2019

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.

The Journal of experimental medicine

Wu J,Chen YJ,Dobbs N,Sakai T,Liou J,Miner JJ,Yan N

14-0031 was used in Functional assays to uncover a critical IFN-independent function of STING that regulates calcium homeostasis, ER stress, and T cell survival.

Mon Apr 01 00:00:00 EDT 2019

Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection.

Proceedings of the National Academy of Sciences of the United States of America

Zheng M,Li D,Zhao Z,Shytikov D,Xu Q,Jin X,Liang J,Lou J,Wu S,Wang L,Hu H,Zhou Y,Gao X,Lu L

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Tue Jun 18 00:00:00 EDT 2019

Mouse PVRIG Has CD8⁺ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity.

Cancer immunology research

Murter B,Pan X,Ophir E,Alteber Z,Azulay M,Sen R,Levy O,Dassa L,Vaknin I,Fridman-Kfir T,Salomon R,Ravet A,Tam A,Levin D,Vaknin Y,Tatirovsky E,Machlenkin A,Pardoll D,Ganguly S

14-0031-82 was used in In vitro experiments to describe that poliovirus receptor-related immunoglobulin domain protein (PVRIG) acts as a coinhibitory receptor in mice.

Fri Feb 01 00:00:00 EST 2019

Inhibition of T cell activation and function by the adaptor protein CIN85.

Science signaling

Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T

14-0031-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.

Tue Feb 05 00:00:00 EST 2019

1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension.

British journal of pharmacology

Mikolajczyk TP,Nosalski R,Skiba DS,Koziol J,Mazur M,Justo-Junior AS,Kowalczyk P,Kusmierczyk Z,Schramm-Luc A,Luc K,Maffia P,Graham D,Kiss AK,Naruszewicz M,Guzik TJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

Thymic Development of a Unique Bone Marrow-Resident Innate-like T Cell Subset with a Potent Innate Immune Function.

Journal of immunology (Baltimore, Md. : 1950)

Yamamoto R,Xu Y,Ikeda S,Sumida K,Tanaka H,Hozumi K,Takaori-Kondo A,Minato N

14-0031-82 was used in Cell Culture to suggest that αβT lineage cells that are developed in the thymus by default of TCR-mediated selection are maintained and differentiated to innate-like T cells in BM and may play a role in innate immunity in the hematopoietic environment.

Mon Jul 01 00:00:00 EDT 2019

Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.

Mammalian genome : official journal of the International Mammalian Genome Society

Avery JT,Jimenez RV,Blake JL,Wright TT,Leόn-Ruiz B,Schoeb TR,Szalai AJ,Bullard DC

14-0031-82 was used in Flow Cytometry to suggest that the 77His variant of CD11b can compromise the ability of DCs to induce antigen-driven T cell proliferation.

Tue Oct 01 00:00:00 EDT 2019

K_Ca3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats.

Journal of the American Heart Association

She G,Ren YJ,Wang Y,Hou MC,Wang HF,Gou W,Lai BC,Lei T,Du XJ,Deng XL

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Western Blot

Tue Jan 08 00:00:00 EST 2019

CD160 serves as a negative regulator of NKT cells in acute hepatic injury.

Nature communications

Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Jul 22 00:00:00 EDT 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.

Nature communications

Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Sep 26 00:00:00 EDT 2019

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.

Nature communications

Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Sep 26 00:00:00 EDT 2019

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.

Nature communications

Kang YH,Biswas A,Field M,Snapper SB

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

Qa-1-Restricted CD8⁺ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.

Cell reports

Anderson CK,Reilly EC,Lee AY,Brossay L

14-0031 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.

Tue Apr 09 00:00:00 EDT 2019

The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.

Cell reports

Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS

14-0031-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.

Tue Sep 17 00:00:00 EDT 2019

Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.

Frontiers in immunology

Di Giovangiulio M,Rizzo A,Franzè E,Caprioli F,Facciotti F,Onali S,Favale A,Stolfi C,Fehling HJ,Monteleone G,Fantini MC

14-0031-82 was used in In vitro Assay, Functional assay to investigate the role of T helper type 1-like Tregs in the dextran sulfate model of colitis.

Wed Oct 21 00:00:00 EDT 2020

Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.

Frontiers in immunology

Di Giovangiulio M,Rizzo A,Franzè E,Caprioli F,Facciotti F,Onali S,Favale A,Stolfi C,Fehling HJ,Monteleone G,Fantini MC

14-0031-82 was used in In vitro Assay, Functional assay to investigate the role of T helper type 1-like Tregs in the dextran sulfate model of colitis.

Wed Oct 21 00:00:00 EDT 2020

PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.

Frontiers in immunology

Mizuno R,Sugiura D,Shimizu K,Maruhashi T,Watada M,Okazaki IM,Okazaki T

14-0031 was used in Flow cytometry/Cell sorting to indicate that PD-1 primarily targets TCR signal in the inhibition of functional T cell activation.

Tue Aug 04 00:00:00 EDT 2020

Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells.

Journal for immunotherapy of cancer

Gao W,Zhang X,Yang W,Dou D,Zhang H,Tang Y,Zhong W,Meng J,Bai Y,Liu Y,Yang L,Chen S,Liu H,Yang C,Sun T

14-0031-82 was used in Flow Cytometry to investigate if a potential option for enhancing the efficacy of PD-1 inhibitors in clinical applications exists.

Wed Aug 28 00:00:00 EDT 2019

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models.

Acta neuropathologica communications

Martinez-Velez N,Marigil M,García-Moure M,Gonzalez-Huarriz M,Aristu JJ,Ramos-García LI,Tejada S,Díez-Valle R,Patiño-García A,Becher OJ,Gomez-Manzano C,Fueyo J,Alonso MM

14-0031-82 was used in Immunohistochemistry to evaluate the feasibility, safety and therapeutic efficacy of Delta-24-RGD, a genetically engineered tumor-selective adenovirus, in combination with radiotherapy in pediatric high grade glioma and diffuse intrinsic pontine glioma models.

Mon Apr 29 00:00:00 EDT 2019

Temporal changes within the (bladder) tumor microenvironment that accompany the therapeutic effects of the immunocytokine NHS-IL12.

Journal for immunotherapy of cancer

Morillon YM,Su Z,Schlom J,Greiner JW

14-0031-82 was used in Flow Cytometry to examine, NHS-muIL12, which consists of two molecules of murine IL-12 fused to NHS76, a tumor necrosis-targeting human IgG1, as an immunotherapeutic in an orthotopic MB49luc bladder tumor model.

Tue Jun 11 00:00:00 EDT 2019

Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy.

Clinical and molecular allergy : CMA

Wagenaar L,van Roest M,Kruijssen LJW,Simons PJ,Boon L,Vonk MM,van Esch BCAM,Knippels LMJ,Garssen J,Pieters RHH,Smit JJ

14-0031 was used in an ELISA assay to show that scFOS/lcFOS diet improves the safety of SCIT, as evidenced by lower anaphylactic responses without compromising the efficacy in a mouse model for peanut allergy.

Fri Oct 06 00:00:00 EDT 2023

Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.

Frontiers in immunology

Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C

14-0031 was used in in vitro experiments to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.

Mon Oct 19 00:00:00 EDT 2020

Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.

Frontiers in immunology

Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C

14-0031 was used in in vitro experiments to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.

Mon Oct 19 00:00:00 EDT 2020

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability.

Frontiers in immunology

Ronin E,Lubrano di Ricco M,Vallion R,Divoux J,Kwon HK,Grégoire S,Collares D,Rouers A,Baud V,Benoist C,Salomon BL

14-0031-82 was used in Flow Cytometry to show that RelA, a key member of the NF-κB complex, is critical for Treg biology as it promotes both the generation of their effector phenotype and the maintenance of their identity.

Thu Oct 29 00:00:00 EDT 2020

CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells.

Journal of neuroinflammation

Yang CL,Zhang P,Liu RT,Zhang N,Zhang M,Li H,Du T,Li XL,Dou YC,Duan RS

14-0031-82 was used in Flow Cytometry to investigate the function of NK cells in experimental autoimmune myasthenia gravis in vivo.

Sun Dec 29 00:00:00 EST 2019

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Nature

Garaycoechea JI,Crossan GP,Langevin F,Mulderrig L,Louzada S,Yang F,Guilbaud G,Park N,Roerink S,Nik-Zainal S,Stratton MR,Patel KJ

14-0031 was used in Flow cytometry/Cell sorting to identify how the choice of DNA-repair pathway and a stringent p53 response limit the transmission of aldehyde-induced mutations in stem cells.

Thu Jan 11 00:00:00 EST 2018

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression.

The Journal of clinical investigation

Kawano Y,Zavidij O,Park J,Moschetta M,Kokubun K,Mouhieddine TH,Manier S,Mishima Y,Murakami N,Bustoros M,Pistofidis RS,Reidy M,Shen YJ,Rahmat M,Lukyanchykov P,Karreci ES,Tsukamoto S,Shi J,Takagi S,Huynh D,Sacco A,Tai YT,Chesi M,Bergsagel PL,Roccaro AM,Azzi J,Ghobrial IM

14-0031 was used in Functional assays to study the therapeutic potential of blocking type 1 interferon signalling to inhibit multiple myeloma-driven regulatory T cell expansion and immunosuppression.

Fri Jun 01 00:00:00 EDT 2018

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.

The Journal of clinical investigation

Ostrov DA,Alkanani A,McDaniel KA,Case S,Baschal EE,Pyle L,Ellis S,Pöllinger B,Seidl KJ,Shah VN,Garg SK,Atkinson MA,Gottlieb PA,Michels AW

14-0031-82 was used in Functional assay to demonstrate that methyldopa specifically blocked DQ8 in patients with recent-onset T1D and reduced inflammatory T cell responses to insulin, highlighting the relevance of blocking disease-specific MHC class II antigen presentation to treat autoimmunity.

Tue May 01 00:00:00 EDT 2018

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8⁺ T cells.

The Journal of experimental medicine

Delpoux A,Michelini RH,Verma S,Lai CY,Omilusik KD,Utzschneider DT,Redwood AJ,Goldrath AW,Benedict CA,Hedrick SM

14-0031 was used in Flow cytometry/Cell sorting to show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells.

Mon Feb 05 00:00:00 EST 2018

IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.

The Journal of experimental medicine

Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B

14-0031 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.

Mon Apr 02 00:00:00 EDT 2018

Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis.

Journal of the American Society of Nephrology : JASN

Qiao X,Rao P,Zhang Y,Liu L,Pang M,Wang H,Hu M,Tian X,Zhang J,Zhao Y,Wang XM,Wang C,Yu H,Guo F,Cao Q,Wang Y,Wang YM,Zhang GY,Lee VW,Alexander SI,Zheng G,Harris DCH

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry (Frozen)

Thu Feb 01 00:00:00 EST 2018

Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis.

Journal of the American Society of Nephrology : JASN

Qiao X,Rao P,Zhang Y,Liu L,Pang M,Wang H,Hu M,Tian X,Zhang J,Zhao Y,Wang XM,Wang C,Yu H,Guo F,Cao Q,Wang Y,Wang YM,Zhang GY,Lee VW,Alexander SI,Zheng G,Harris DCH

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry (Frozen)

Thu Feb 01 00:00:00 EST 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme.

The EMBO journal

Bending D,Paduraru A,Ducker CB,Prieto Martín P,Crompton T,Ono M

14-0031 was used in Functional assays to study the effects of inflammation on the flux of new Foxp3 expressors and the rate of Foxp3 transcription.

Wed Aug 15 00:00:00 EDT 2018

IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.

Cancer research

Gibson HM,McKnight BN,Malysa A,Dyson G,Wiesend WN,McCarthy CE,Reyes J,Wei WZ,Viola-Villegas NT

14-0031-82 was used in Radioimmune Assays to present a novel approach to monitor therapeutic outcomes via IFNγ-targeted positron emission tomography.

Mon Oct 01 00:00:00 EDT 2018

Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.

British journal of pharmacology

Basler M,Maurits E,de Bruin G,Koerner J,Overkleeft HS,Groettrup M

14-0031 was used in Functional assays to investigate the selectivity and biological activity of LU-005i, a recently described inhibitor of the immunoproteasome.

Mon Jan 01 00:00:00 EST 2018

In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo.

Frontiers in immunology

Flores-Santibáñez F,Cuadra B,Fernández D,Rosemblatt MV,Núñez S,Cruz P,Gálvez-Cancino F,Cárdenas JC,Lladser A,Rosemblatt M,Bono MR,Sauma D

14-0031 was used in Flow cytometry/Cell sorting to evaluate the functional properties of in vitro-generated IL-17-producing CD8+ T cells and elucidate their potential to become long lasting memory cells.

Wed Apr 03 00:00:00 EDT 2019

Semaphorin-3E Produced by Immature Dendritic Cells Regulates Activated Natural Killer Cells Migration.

Frontiers in immunology

Alamri A,Rahman R,Zhang M,Alamri A,Gounni AS,Kung SKP

14-0031 was used in Flow cytometry/Cell sorting to reveal a novel role of Sema-3E in limiting NK-cell migrations toward iDC in NK-DC crosstalk.

Thu Jul 11 00:00:00 EDT 2019

Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.

Mucosal immunology

Varanasi SK,Rajasagi NK,Jaggi U,Rouse BT

14-0031 was used in Flow cytometry/Cell sorting to investigate IL-18's mechanisms to control of inflammatory lesions in the cornea caused by the herpes infection.

Thu Nov 01 00:00:00 EDT 2018

Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.

Glia

Villadiego J,Labrador-Garrido A,Franco JM,Leal-Lasarte M,De Genst EJ,Dobson CM,Pozo D,Toledo-Aral JJ,Roodveldt C

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Mon Jan 01 00:00:00 EST 2018

Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh.

Development (Cambridge, England)

Solanki A,Yanez DC,Ross S,Lau CI,Papaioannou E,Li J,Saldaña JI,Crompton T

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Jan 31 00:00:00 EST 2018

Aire controls the recirculation of murine Foxp3⁺ regulatory T-cells back to the thymus.

European journal of immunology

Cowan JE,Baik S,McCarthy NI,Parnell SM,White AJ,Jenkinson WE,Anderson G

14-0031 was used in Flow cytometry/Cell sorting to re-defines requirements for late stage intrathymic αβT-cell development, and demonstrates that Aire controls a CCR6-CCL20 axis that determines the developmental makeup of the intrathymic T-Reg pool.

Tue May 01 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Thu Feb 01 00:00:00 EST 2018

A Restricted Role for FcγR in the Regulation of Adaptive Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Fransen MF,Benonisson H,van Maren WW,Sow HS,Breukel C,Linssen MM,Claassens JWC,Brouwers C,van der Kaa J,Camps M,Kleinovink JW,Vonk KK,van Heiningen S,Klar N,van Beek L,van Harmelen V,Daxinger L,Nandakumar KS,Holmdahl R,Coward C,Lin Q,Hirose S,Salvatori D,van Hall T,van Kooten C,Mastroeni P,Ossendorp F,Verbeek JS

14-0031 was used in Functional assays to elucidate a redundant role for activating FcγRs in the modulation of the adaptive immune response in vivo.

Sun Apr 15 00:00:00 EDT 2018

IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4⁺ T Cell Migration.

Journal of immunology (Baltimore, Md. : 1950)

Smith CJ,Allard DE,Wang Y,Howard JF,Montgomery SA,Su MA

14-0031 was used in Flow cytometry/Cell sorting to delineate a novel mechanism in which IL-10-induced STAT3 increases S1pr1 expression and CD4+ T cell migration to accelerate T cell-mediated destruction of peripheral nerves.

Thu Mar 01 00:00:00 EST 2018

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Journal of neuroimmunology

Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment.

Nature communications

Wunderlich CM,Ackermann PJ,Ostermann AL,Adams-Quack P,Vogt MC,Tran ML,Nikolajev A,Waisman A,Garbers C,Theurich S,Mauer J,Hövelmeyer N,Wunderlich FT

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunocytochemistry

Wed Apr 25 00:00:00 EDT 2018

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment.

Nature communications

Wunderlich CM,Ackermann PJ,Ostermann AL,Adams-Quack P,Vogt MC,Tran ML,Nikolajev A,Waisman A,Garbers C,Theurich S,Mauer J,Hövelmeyer N,Wunderlich FT

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunocytochemistry

Wed Apr 25 00:00:00 EDT 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response.

Scientific reports

Rodríguez-Baena FJ,Redondo-García S,Peris-Torres C,Martino-Echarri E,Fernández-Rodríguez R,Plaza-Calonge MDC,Anderson P,Rodríguez-Manzaneque JC

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Aug 30 00:00:00 EDT 2018

Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.

Neoplasia (New York, N.Y.)

Pittala S,Krelin Y,Shoshan-Barmatz V

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Fri Jun 01 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses.

Frontiers in immunology

Min CK,Kim HI,Ha NY,Kim Y,Kwon EK,Yen NTH,Youn JI,Jeon YK,Inn KS,Choi MS,Cho NH

14-0031 was used in Flow cytometry/Cell sorting to show that the induction of the type I IFN/IL-10 axis by O. tsutsugamushi infection might play a significant role in the suppression of T cell responses and contribute to the short longevity of cell-mediated immunity, often observed in scrub typhus patients.

Mon Sep 30 00:00:00 EDT 2019

Diosgenin promotes antitumor immunity and PD-1 antibody efficacy against melanoma by regulating intestinal microbiota.

Cell death & disease

Dong M,Meng Z,Kuerban K,Qi F,Liu J,Wei Y,Wang Q,Jiang S,Feng M,Ye L

14-0031 was used in Flow cytometry/Cell sorting to conclude that diosgenin can be used as a microecological regulator to induce antitumor immunity and improve the efficacy of immune checkpoint antibody, making it more suitable for the treatment of malignant tumors.

Wed Oct 10 00:00:00 EDT 2018

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

Genome biology

Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC

14-0031 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.

Wed Nov 07 00:00:00 EST 2018

Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.

JCI insight

Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S

14-0031 was used in Functional assays to demonstrate that β-oxidation links metabolism and immune responsiveness.

Thu Mar 22 00:00:00 EDT 2018

Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.

PloS one

Tong H,Miyake Y,Mi-Ichi F,Iwakura Y,Hara H,Yoshida H

14-0031 was used in Functional assays to study the role of Apaf1 in immune responses.

Tue Jul 24 00:00:00 EDT 2018

Factors Produced by Macrophages Eliminating Apoptotic Cells Demonstrate Pro-Resolutive Properties and Terminate Ongoing Inflammation.

Frontiers in immunology

Bonnefoy F,Gauthier T,Vallion R,Martin-Rodriguez O,Missey A,Daoui A,Valmary-Degano S,Saas P,Couturier M,Perruche S

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that the factors produced by macrophages eliminating apoptotic cells were sufficient to reboot the resolution of inflammation in vivo, and thus definitively terminated ongoing chronic inflammation.

Thu Oct 03 00:00:00 EDT 2019

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.

eLife

Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M

Thu Sep 06 00:00:00 EDT 2018

MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.

JCI insight

Lee-Sherick AB,Jacobsen KM,Henry CJ,Huey MG,Parker RE,Page LS,Hill AA,Wang X,Frye SV,Earp HS,Jordan CT,DeRyckere D,Graham DK

14-0031 was used in Functional assays to demonstrate both the direct therapeutic effects of MERTK inhibition on leukaemia cells and the induction of anti-leukaemia immunity via suppression of the coinhibitory PD-1 axis.

Fri Nov 02 00:00:00 EDT 2018

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.

Nature communications

Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q

14-0031 was used in Functional assays to show reduced expression of the transcription factor RFX1 in CD4+ T cells from patients with systemic lupus erythematosus which leads to IL-17A overexpression through increased histone H3 acetylation and decreased DNA methylation.

Thu Feb 08 00:00:00 EST 2018

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.

Frontiers in immunology

Heinonen T,Ciarlo E,Théroude C,Pelekanou A,Herderschee J,Le Roy D,Roger T

14-0031 was used in Flow cytometry/Cell sorting to investigate if SIRT5 deficiency effects immune cell development, cytokine production and proliferation by macrophages and splenocytes exposed to microbial and immunological stimuli.

Wed Oct 02 00:00:00 EDT 2019

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.

PloS one

Deshpande NR,Uhrlaub JL,Way SS,Nikolich-Žugich J,Kuhns MS

14-0031 was used in Flow cytometry/Cell sorting to explore if CD4+ T cell responses to immunization or infection increase with aging.

Tue Dec 11 00:00:00 EST 2018

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.

Nature communications

Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP

14-0031 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.

Thu Jan 04 00:00:00 EST 2018

Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.

Scientific reports

Chen EW,Brzostek J,Gascoigne NRJ,Rybakin V

14-0031 was used in Flow cytometry/Cell sorting to develop a screening strategy for the identification of small molecules affecting T cell receptor (TCR) signalling based on the uncoupling of TCR stimulation from cellular responses in developing thymocytes.

Tue Jul 03 00:00:00 EDT 2018

Regulation of the effector function of CD8⁺ T cells by gut microbiota-derived metabolite butyrate.

Scientific reports

Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A

14-0031 was used in in vitro experiments to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.

Wed Sep 26 00:00:00 EDT 2018

Regulation of the effector function of CD8⁺ T cells by gut microbiota-derived metabolite butyrate.

Scientific reports

Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A

14-0031 was used in in vitro experiments to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.

Wed Sep 26 00:00:00 EDT 2018

IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.

Cell reports

Fabié A,Mai LT,Dagenais-Lussier X,Hammami A,van Grevenynghe J,Stäger S

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that IRF-5 is increasingly expressed in interferon (IFN)-γ+ CD4 T cells over the course of L. donovani infection.

Tue Jul 31 00:00:00 EDT 2018

Feedback control of AHR signalling regulates intestinal immunity.

Nature

Schiering C,Wincent E,Metidji A,Iseppon A,Li Y,Potocnik AJ,Omenetti S,Henderson CJ,Wolf CR,Nebert DW,Stockinger B

14-0031 was used in Functional assays to study the effects of dysregulated Cyp1a expression on the reservoir of natural aryl hydrocarbon receptor ligands.

Thu Feb 09 00:00:00 EST 2017

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Cell

Kortlever RM,Sodir NM,Wilson CH,Burkhart DL,Pellegrinet L,Brown Swigart L,Littlewood TD,Evan GI

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Nov 30 00:00:00 EST 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Regulatory T cells promote myelin regeneration in the central nervous system.

Nature neuroscience

Dombrowski Y,O'Hagan T,Dittmer M,Penalva R,Mayoral SR,Bankhead P,Fleville S,Eleftheriadis G,Zhao C,Naughton M,Hassan R,Moffat J,Falconer J,Boyd A,Hamilton P,Allen IV,Kissenpfennig A,Moynagh PN,Evergren E,Perbal B,Williams AC,Ingram RJ,Chan JR,Franklin RJM,Fitzgerald DC

14-0031 was used in Functional assays to elucidate the role of regulatory T cells in promoting oligodendrocyte differentiation andmyelination in the central nervous system.

Mon May 01 00:00:00 EDT 2017

T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.

Circulation research

Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ

14-0031 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.

Fri May 12 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

PTEN drives Th17 cell differentiation by preventing IL-2 production.

The Journal of experimental medicine

Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Nov 06 00:00:00 EST 2017

LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.

The Journal of experimental medicine

Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H

14-0031 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.

Sun Jan 01 00:00:00 EST 2017

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.

The Journal of experimental medicine

Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z

14-0031-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.

Wed Feb 01 00:00:00 EST 2017

Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.

Nature protocols

Kurachi M,Kurachi J,Chen Z,Johnson J,Khan O,Bengsch B,Stelekati E,Attanasio J,McLane LM,Tomura M,Ueha S,Wherry EJ

14-0031 was used in Functional assays to develop an optimised mouse CD8 T cell retroviral transduction protocol for in vivo assessment of gene function.

Fri Sep 01 00:00:00 EDT 2017

Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.

The Journal of allergy and clinical immunology

Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM

14-0031 was used in in vitro experiments to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.

Wed Feb 01 00:00:00 EST 2017

Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone.

The Journal of allergy and clinical immunology

Ramirez-Carrozzi V,Sambandam A,Zhou M,Yan D,Kang J,Wu X,Suto E,Baca M,Austin C,Xu M,Lee W,Pappu R

14003182 was used in flow cytometry to study the effect of IL-13 and IL-33 pathways in dysregulated type 2 inflammation.

Wed Feb 01 00:00:00 EST 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154-CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice.

Frontiers in immunology

Govender L,Wyss JC,Kumar R,Pascual M,Golshayan D

14-0031 was used in Flow cytometry/Cell sorting to study regulatory T cell-based immunotherapy for solid organ transplantation and complementary immunomodulatory strategies.

Wed Nov 20 00:00:00 EST 2019

Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.

Frontiers in immunology

Powell DA,Frelinger JA

14-0031 was used in Flow cytometry/Cell sorting to show the role of Slc11a1 in resistance to pulmonary Francisella infection in mice.

Wed Nov 20 00:00:00 EST 2019

Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy.

Frontiers in immunology

Chavez-Galan L,Vesin D,Uysal H,Blaser G,Benkhoucha M,Ryffel B,Quesniaux VFJ,Garcia I

14-0031 was used in Flow cytometry/Cell sorting to provide insight into the crucial role played by the transmembrane TNF/TNF receptor 2 pathway in myeloid-derived suppressor cell suppressive activity required during acute pleural infection to attenuate excessive inflammation generated by the infection.

Wed Nov 20 00:00:00 EST 2019

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.

PLoS pathogens

Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA

14-0031-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.

Fri Sep 01 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

T cell-dependent antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies in mice.

European journal of immunology

Akkaya M,Akkaya B,Sheehan PW,Miozzo P,Pena M,Qi CF,Manzella-Lapeira J,Bolland S,Pierce SK

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Wed Nov 01 00:00:00 EDT 2017

NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.

European journal of immunology

Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S

14-0031 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.

Fri Sep 01 00:00:00 EDT 2017

Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.

Journal of immunology (Baltimore, Md. : 1950)

Leigh ND,O'Neill RE,Du W,Chen C,Qiu J,Ashwell JD,McCarthy PL,Chen GL,Cao X

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.

Sat Jul 01 00:00:00 EDT 2017

Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.

Journal of immunology (Baltimore, Md. : 1950)

Zaid A,Hor JL,Christo SN,Groom JR,Heath WR,Mackay LK,Mueller SN

14-0031 was used in Flow cytometry/Cell sorting to examine the signals required for the migration of tissue-resident memory T cells within the constrained epidermal environment.

Sun Oct 01 00:00:00 EDT 2017

Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.

Journal of cellular and molecular medicine

Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells.

BMB reports

Jang E,Lee HR,Lee GH,Oh AR,Cha JY,Igarashi K,Youn J

14-0031 was used in Flow cytometry/Cell sorting to investigate whether Bach2 is a component of the network of factors that regulates interleukin-2 expression.

Fri Sep 01 00:00:00 EDT 2017

miR-451 limits CD4⁺ T cell proliferative responses to infection in mice.

Immunologic research

Chapman LM,Ture SK,Field DJ,Morrell CN

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.

Tue Aug 01 00:00:00 EDT 2017

Macrophage regulation of B cell proliferation.

Cellular immunology

Goldman N,Valiuskyte K,Londregan J,Swider A,Somerville J,Riggs JE

14-0031 was used in Flow cytometry/Cell sorting to assess the ability of peritoneal cavity B cells to respond to surrogate activating signals in the presence of high numbers of macrophages.

Sat Apr 01 00:00:00 EDT 2017

Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection.

Infection and immunity

Ehrlich AK,Fernández OL,Rodriguez-Pinto D,Castilho TM,Corral Caridad MJ,Goldsmith-Pestana K,Saravia NG,McMahon-Pratt D

14-0031 was used in Flow cytometry/Cell sorting to study the ability of Toll like receptor 9 ligand CpG to modulate established disease in the Leishmania panamensis mouse model.

Wed Mar 01 00:00:00 EST 2017

Avoiding phagocytosis-related artifact in myeloid derived suppressor cell T-lymphocyte suppression assays.

Journal of immunological methods

Davis RJ,Silvin C,Allen CT

14-0031 was used in Flow cytometry/Cell sorting to propose model-specific validation of microbead-based MDSC assays, or use of an alternative stimulation approach such as plate bound CD3/28 antibodies.

Sun Jan 01 00:00:00 EST 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunohistochemistry

Sat Apr 01 00:00:00 EDT 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Jan 06 00:00:00 EST 2017

The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.

Nature microbiology

Grau KR,Roth AN,Zhu S,Hernandez A,Colliou N,DiVita BB,Philip DT,Riffe C,Giasson B,Wallet SM,Mohamadzadeh M,Karst SM

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Tue Oct 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.

Scientific reports

Van Den Ham KM,Smith LK,Richer MJ,Olivier M

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of protein tyrosine phosphatase activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology.

Fri Jul 14 00:00:00 EDT 2017

Alternative activation generates IL-10 producing type 2 innate lymphoid cells.

Nature communications

Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J

14-0031 was used in Immunocytochemistry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.

Fri Dec 01 00:00:00 EST 2017

Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein.

Oncotarget

Morillon YM,Hammond SA,Durham NM,Schlom J,Greiner JW

14-0031 was used in Functional assays to study the efficacy of combining a recombinant poxvirus-based vaccine with a novel murine GITR ligand fusion protein in cancer immunotherapy.

Tue Sep 26 00:00:00 EDT 2017

Functional MRI for characterization of renal perfusion impairment and edema formation due to acute kidney injury in different mouse strains.

PloS one

Tewes S,Gueler F,Chen R,Gutberlet M,Jang MS,Meier M,Mengel M,Hartung D,Wacker F,Rong S,Hueper K

14003182 was used in immunohistochemistry to study acute kidney injury in mice by noninvasive measurement of renal perfusion and tissue edema using functional MRI

Wed Aug 23 00:00:00 EDT 2017

Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.

JCI insight

Lam JH,Chua YL,Lee PX,Martínez Gómez JM,Ooi EE,Alonso S

14-0031 was used in Flow cytometry/Cell sorting to establish the development of dengue vaccine candidates that induce protective CD8+ T cells despite the presence of enhancing, interfering maternal antibodies.

Thu Dec 21 00:00:00 EST 2017

Oxidized CaMKII promotes asthma through the activation of mast cells.

JCI insight

Qu J,Do DC,Zhou Y,Luczak E,Mitzner W,Anderson ME,Gao P

14-0031 was used in Flow cytometry/Cell sorting to test the effect of ox-CaMKII on IgE-mediated mast cell activation in an allergen-induced mouse model of asthma.

Thu Jan 12 00:00:00 EST 2017

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.

Clinical and translational allergy

Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J

14-0031 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.

Fri Apr 08 00:00:00 EDT 2022

Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice.

BMC immunology

Vazquez-Mateo C,Collins J,Fleury M,Dooms H

14-0031 was used in an ELISA assay to evaluate the use of anti-IL7Ra antibodies to modulate autoreactive T cell responses.

Wed Mar 29 00:00:00 EDT 2017

Functional characterization of the lysosomal membrane protein TMEM192 in mice.

Oncotarget

Nguyen TL,Schneppenheim J,Rudnik S,Lüllmann-Rauch R,Bernreuther C,Hermans-Borgmeyer I,Glatzel M,Saftig P,Schröder B

14-0031-82 was used in Flow Cytometry to conclude that under basal conditions in vivo the loss of TMEM192 can be efficiently compensated by alternative pathways.

Tue Jul 04 00:00:00 EDT 2017

T follicular helper and T follicular regulatory cells have different TCR specificity.

Nature communications

Maceiras AR,Almeida SCP,Mariotti-Ferrandiz E,Chaara W,Jebbawi F,Six A,Hori S,Klatzmann D,Faro J,Graca L

14-0031 was used in Flow cytometry/Cell sorting to determine the effect of T cell receptor specificity in the differentiation of T follicular helper and regulatory cells.

Fri Apr 21 00:00:00 EDT 2017

Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.

Oncoimmunology

Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF

14-0031 was used in Flow cytometry/Cell sorting to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.

Tue Jan 12 00:00:00 EST 2021

Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.

Oncotarget

Oh DS,Kim H,Oh JE,Jung HE,Lee YS,Park JH,Lee HK

14-0031 was used in Flow cytometry/Cell sorting to show that intratumoral Treg-targeted PDT could specifically modulate tumor microenvironments by depleting Tregs and could be used as a novel cancer immunotherapy technique.

Tue Jul 18 00:00:00 EDT 2017

Signalling strength determines proapoptotic functions of STING.

Nature communications

Gulen MF,Koch U,Haag SM,Schuler F,Apetoh L,Villunger A,Radtke F,Ablasser A

14-0031 was used in Flow cytometry/Cell sorting to demonstrate how the magnitude of STING signalling can shape distinct effector responses.

Tue Sep 05 00:00:00 EDT 2017

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton.

eLife

Britton GJ,Ambler R,Clark DJ,Hill EV,Tunbridge HM,McNally KE,Burton BR,Butterweck P,Sabatos-Peyton C,Hampton-O'Neil LA,Verkade P,Wülfing ChC,Wraith DC

14-0031 was used in Functional assays to investigate the role of protein kinase PKCθ in linking proximal T cell and notch signaling by a spatiotemporally constrained mechanism.

Tue Jan 31 00:00:00 EST 2017

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Nature communications

Wang J,He N,Zhang N,Quan D,Zhang S,Zhang C,Yu RT,Atkins AR,Zhu R,Yang C,Cui Y,Liddle C,Downes M,Xiao H,Zheng Y,Auwerx J,Evans RM,Leng Q

14-0031 was used in Western Blotting to study whether transcriptional regulation helps conserve positively selected thymocytes from being purged by negative selection.

Mon Oct 16 00:00:00 EDT 2017

Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.

PloS one

Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F

14-0031-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.

Tue Sep 05 00:00:00 EDT 2017

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Nature

Eil R,Vodnala SK,Clever D,Klebanoff CA,Sukumar M,Pan JH,Palmer DC,Gros A,Yamamoto TN,Patel SJ,Guittard GC,Yu Z,Carbonaro V,Okkenhaug K,Schrump DS,Linehan WM,Roychoudhuri R,Restifo NP

14-0031 was used in in vitro experiments to discover an ionic checkpoint that blocks T cell function in tumours, identifying potential new strategies for cancer immunotherapy.

Thu Sep 22 00:00:00 EDT 2016

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.

Nature genetics

Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS

14003182 was used in blocking or activating experiment to elucidate the role of TfR1 in adaptive immunity

Fri Jan 01 00:00:00 EST 2016

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.

Nature genetics

14003182 was used in blocking or activating experiment to elucidate the role of TfR1 in adaptive immunity

Fri Jan 01 00:00:00 EST 2016

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.

Nature immunology

Wei J,Long L,Yang K,Guy C,Shrestha S,Chen Z,Wu C,Vogel P,Neale G,Green DR,Chi H

14-0031 was used in Functional assays to show that autophagy is active in regulatory T cells and supports their lineage stability and survival fitness.

Tue Mar 01 00:00:00 EST 2016

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Nature immunology

Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D

14-0031 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.

Wed Jun 01 00:00:00 EDT 2016

Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.

Nature immunology

Zhong C,Cui K,Wilhelm C,Hu G,Mao K,Belkaid Y,Zhao K,Zhu J

14003182 was used in flow cytometry to explore the contributions of GATA3 to the group 3 innate lymphoid cells

Mon Feb 01 00:00:00 EST 2016

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.

The Journal of clinical investigation

Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W

14-0031 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.

Fri Apr 01 00:00:00 EDT 2016

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

The Journal of clinical investigation

Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS

14-0031 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.

Tue Nov 01 00:00:00 EDT 2016

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

The Journal of clinical investigation

Tue Nov 01 00:00:00 EDT 2016

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.

Nucleic acids research

Yang Y,Poe JC,Yang L,Fedoriw A,Desai S,Magnuson T,Li Z,Fedoriw Y,Araki K,Gao Y,Tateishi S,Sarantopoulos S,Vaziri C

14-0031-82 was used in Flow Cytometry to investigate the physiological roles of Rad18 in DNA damage tolerance and carcinogenesis.

Thu May 19 00:00:00 EDT 2016

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.

The Journal of experimental medicine

Yoon J,Leyva-Castillo JM,Wang G,Galand C,Oyoshi MK,Kumar L,Hoff S,He R,Chervonsky A,Oppenheim JJ,Kuchroo VK,van den Brink MR,Malefyt Rde W,Tessier PA,Fuhlbrigge R,Rosenstiel P,Terhorst C,Murphy G,Geha RS

14-0031 was used in Functional assays to elucidate the mechanisms behind DC-derived IL-23 in a model of skin inflammation.

Mon Sep 19 00:00:00 EDT 2016

Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.

Arthritis & rheumatology (Hoboken, N.J.)

Kaneko K,Williams RO,Dransfield DT,Nixon AE,Sandison A,Itoh Y

14-0031 was used in Functional assays to investigate the therapeutic potential of selective inhibition of membrane type 1 MMP in rheumatoid arthritis.

Mon Feb 01 00:00:00 EST 2016

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

Science advances

Ghari F,Quirke AM,Munro S,Kawalkowska J,Picaud S,McGouran J,Subramanian V,Muth A,Williams R,Kessler B,Thompson PR,Fillipakopoulos P,Knapp S,Venables PJ,La Thangue NB

14-0031 was used in Functional assays to investigate the mechanism of action of PAD4.

Mon Feb 01 00:00:00 EST 2016

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.

Autophagy

Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2016

Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.

Proceedings of the National Academy of Sciences of the United States of America

Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK

14-0031 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.

Tue Feb 09 00:00:00 EST 2016

Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.

Arteriosclerosis, thrombosis, and vascular biology

Harmon DB,Srikakulapu P,Kaplan JL,Oldham SN,McSkimming C,Garmey JC,Perry HM,Kirby JL,Prohaska TA,Gonen A,Hallowell P,Schirmer B,Tsimikas S,Taylor AM,Witztum JL,McNamara CA

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of B-cell functions in obesity-induced metabolic dysfunction.

Fri Apr 01 00:00:00 EDT 2016

Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma.

Frontiers in immunology

Blanquiceth Y,Rodríguez-Perea AL,Tabares Guevara JH,Correa LA,Sánchez MD,Ramírez-Pineda JR,Velilla PA

14-0031 was used in Functional assays to evaluate the in vivo effect of atorvastatin on regulatory T cells, and its association with the inflammatory process in a model of allergic asthma.

Wed Nov 20 00:00:00 EST 2019

Transforming growth factor-β1 sustains the survival of Foxp3(+) regulatory cells during late phase of oropharyngeal candidiasis infection.

Mucosal immunology

Bhaskaran N,Quigley C,Weinberg A,Huang A,Popkin D,Pandiyan P

14-0031 was used in Functional assays to investigate how CD4(+)CD25(+)Foxp3(+) Tregs are controlled during mouse oropharyngeal candidiasis infection.

Fri Jul 01 00:00:00 EDT 2016

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.

Mucosal immunology

Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.

Tue Mar 01 00:00:00 EST 2016

Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.

PLoS pathogens

Gillespie AL,Teoh J,Lee H,Prince J,Stadnisky MD,Anderson M,Nash W,Rival C,Wei H,Gamache A,Farber CR,Tung K,Brown MG

14-0031 was used in Flow cytometry/Cell sorting to identify genetic modifiers of the host immune response to cytomegalovirus.

Mon Feb 01 00:00:00 EST 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.

Journal of immunology (Baltimore, Md. : 1950)

He Z,Wang F,Ma J,Sen S,Zhang J,Gwack Y,Zhou Y,Sun Z

14-0031 was used in Flow cytometry/Cell sorting to identify a functional ubiquitination site, K446, on the transcription factor retinoid acid-related orphan receptor γ t (RORγt).

Mon Aug 15 00:00:00 EDT 2016

SATB1 Plays a Critical Role in Establishment of Immune Tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Kondo M,Tanaka Y,Kuwabara T,Naito T,Kohwi-Shigematsu T,Watanabe A

14-0031-82 was used in Flow Cytometry to study the role of special AT-rich sequence binding protein 1 in the establishment of immune tolerance.

Fri Jan 15 00:00:00 EST 2016

Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.

Journal of immunology (Baltimore, Md. : 1950)

Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA

14-0031 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.

Tue Nov 15 00:00:00 EST 2016

DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases.

Molecules and cells

Nair VS,Song MH,Ko M,Oh KI

14-0031 was used in Functional assays to study the mechanisms that protects conserved non-coding sequence 2 from re-methylation, preventing FoxP3 loss in Tregs under inflammatory conditions.

Thu Dec 01 00:00:00 EST 2016

Erythropoietin increases macrophage-mediated T cell suppression.

Cellular immunology

Wood MA,Goldman N,DePierri K,Somerville J,Riggs JE

14-0031 was used in in vitro experiments to suggest that EPO could increase T cell suppression in the TME by acting directly on macrophages.

Mon Jun 26 00:00:00 EDT 2017

CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.

Scandinavian journal of immunology

Li WM,Liu HR

14-0031 was used in Flow cytometry/Cell sorting to study the expression of cytokines potentially known to recruit regulatory T cells in hepatocellular carcinoma.

Fri Jan 01 00:00:00 EST 2016

Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice.

Infection and immunity

Ruan S,Samuelson DR,Assouline B,Morre M,Shellito JE

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

JCI insight

Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Thu Jul 21 00:00:00 EDT 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins.

The Journal of biological chemistry

Venetz D,Koovely D,Weder B,Neri D

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that interleukin-12 can be reconstituted by sequential reassembly of fusion proteins based on antibody fragments and interleukin-12 subunit mutants.

Fri Aug 26 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia.

Oncoimmunology

Finkel P,Frey B,Mayer F,Bösl K,Werthmöller N,Mackensen A,Gaipl US,Ullrich E

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Nature communications

Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG

14-0031 was used in Flow cytometry/Cell sorting to study how immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner, and involves alterations in intracellular cyclic AMP formation.

Wed May 18 00:00:00 EDT 2016

RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.

Journal of neuroinflammation

Lee JK,Kannarkat GT,Chung J,Joon Lee H,Graham KL,Tansey MG

14-0031 was used in Functional assays to define potential roles for RGS10 in regulating autoimmune responses, showing that deficiency ameliorates the severity of disease in EAE.

Mon Feb 01 00:00:00 EST 2016

C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer.

Oncoimmunology

Rapp M,Grassmann S,Chaloupka M,Layritz P,Kruger S,Ormanns S,Rataj F,Janssen KP,Endres S,Anz D,Kobold S

14-0031 was used in Flow cytometry/Cell sorting to study how CCR4 overexpression in CTL is a promising therapeutic strategy to enhance the efficacy of adoptive T cell transfer (ACT).

Tue Mar 01 00:00:00 EST 2016

Immunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection.

PLoS neglected tropical diseases

Gomes R,Cavalcanti K,Teixeira C,Carvalho AM,Mattos PS,Cristal JR,Muniz AC,Miranda JC,de Oliveira CI,Barral A

14-0031 was used in Flow cytometry/Cell sorting to show that Lu. whitmani salivary proteins are immunogenic in naturally exposed individuals.

Tue Nov 01 00:00:00 EDT 2016

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.

PloS one

Uhde AK,Herder V,Akram Khan M,Ciurkiewicz M,Schaudien D,Teich R,Floess S,Baumgärtner W,Huehn J,Beineke A

14003182 was used in flow cytometry to study the effect of IL-10 signaling in infectious neurological diseases

Fri Aug 25 00:00:00 EDT 2017

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors.

EBioMedicine

Holmgaard RB,Zamarin D,Lesokhin A,Merghoub T,Wolchok JD

14-0031 was used in Flow cytometry/Cell sorting to study the invovlement of myeloid-derived suppressor cells in IDO-expressing B16 tumour progression and therapy resistance.

Fri Apr 01 00:00:00 EDT 2016

Purinergic Signaling as a Regulator of Th17 Cell Plasticity.

PloS one

Fernández D,Flores-Santibáñez F,Neira J,Osorio-Barrios F,Tejón G,Nuñez S,Hidalgo Y,Fuenzalida MJ,Meza D,Ureta G,Lladser A,Pacheco R,Acuña-Castillo C,Guixé V,Quintana FJ,Bono MR,Rosemblatt M,Sauma D

14-0031 was used in Functional assays to suggest that CD39 expression by Th17 cells allows depletion of ATP facilitates IL-10 production and survival during intestinal inflammation resolution.

Wed Jul 19 00:00:00 EDT 2017

Purinergic Signaling as a Regulator of Th17 Cell Plasticity.

PloS one

14-0031 was used in Functional assays to suggest that CD39 expression by Th17 cells allows depletion of ATP facilitates IL-10 production and survival during intestinal inflammation resolution.

Wed Jul 19 00:00:00 EDT 2017

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Scientific reports

Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ

14-0031 was used in Flow cytometry/Cell sorting to suggest that targeting peptidyl arginine deiminases (PAD) is a promising strategy for the treatment of chronic inflammatory disease.

Mon May 23 00:00:00 EDT 2016

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.

Nature communications

Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Fri Jul 15 00:00:00 EDT 2016

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.

Nature communications

Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Fri Jul 15 00:00:00 EDT 2016

Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner.

Scientific reports

Coutaz M,Hurrell BP,Auderset F,Wang H,Siegert S,Eberl G,Ho PC,Radtke F,Tacchini-Cottier F

14-0031-82 was used in Flow Cytometry to elucidate whether Notch signaling is involved in the negative or positive regulation of Th17 cell differentiation.

Thu Dec 15 00:00:00 EST 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.

eLife

Westernberg L,Conche C,Huang YH,Rigaud S,Deng Y,Siegemund S,Mukherjee S,Nosaka L,Das J,Sauer K

14-0031 was used in Functional assays to elucidate the mechanisms underlying the establishment of the Notch-dependent nature of β-selection.

Thu Feb 11 00:00:00 EST 2016

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.

Nature communications

Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Oct 21 00:00:00 EDT 2016

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.

Nature medicine

Mascanfroni ID,Takenaka MC,Yeste A,Patel B,Wu Y,Kenison JE,Siddiqui S,Basso AS,Otterbein LE,Pardoll DM,Pan F,Priel A,Clish CB,Robson SC,Quintana FJ

14-0031 was used in Functional assays to demonstrate that crosstalk between HIF1-α and AHR provides a pathway to modulate the immune response.

Mon Jun 01 00:00:00 EDT 2015

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.

Nature medicine

Mascanfroni ID,Takenaka MC,Yeste A,Patel B,Wu Y,Kenison JE,Siddiqui S,Basso AS,Otterbein LE,Pardoll DM,Pan F,Priel A,Clish CB,Robson SC,Quintana FJ

14-0031 was used in Functional assays to demonstrate that crosstalk between HIF1-α and AHR provides a pathway to modulate the immune response.

Mon Jun 01 00:00:00 EDT 2015

Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.

Nature biotechnology

Chen HJ,Sun J,Huang Z,Hou H,Arcilla M,Rakhilin N,Joe DJ,Choi J,Gadamsetty P,Milsom J,Nandakumar G,Longman R,Zhou XK,Edwards R,Chen J,Chen KY,Bu P,Wang L,Xu Y,Munroe R,Abratte C,Miller AD,Gümüş ZH,Shuler M,Nishimura N,Edelmann W,Shen X,Lipkin SM

14-0031 was used in Flow cytometry/Cell sorting to create chemokine-targeted mouse models that recapitulate the majority of common human somatic CRC mutations.

Mon Jun 01 00:00:00 EDT 2015

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Science (New York, N.Y.)

Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW

14-0031 was used in an ELISA assay to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.

Fri Jul 31 00:00:00 EDT 2015

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.

Immunity

Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H

14-0031-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.

Tue Dec 15 00:00:00 EST 2015

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.

Immunity

Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR

14-0031 was used in in vitro experiments to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.

Tue Dec 15 00:00:00 EST 2015

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.

Nature immunology

Takada K,Van Laethem F,Xing Y,Akane K,Suzuki H,Murata S,Tanaka K,Jameson SC,Singer A,Takahama Y

14-0031 was used in Flow cytometry/Cell sorting to demonstrate a novel aspect of positive selection which tunes the responsiveness of mature CD8(+) T cells.

Thu Oct 01 00:00:00 EDT 2015

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier.

Science translational medicine

Lazear HM,Daniels BP,Pinto AK,Huang AC,Vick SC,Doyle SE,Gale M,Klein RS,Diamond MS

14-0031 was used in Flow cytometry/Cell sorting to establish an indirect antiviral function of IFNλ in which noncanonical signaling through IFNLR1 tightens the blood-brain barrier and restricts viral neuroinvasion.

Wed Apr 22 00:00:00 EDT 2015

Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα.

The Journal of experimental medicine

Mooster JL,Le Bras S,Massaad MJ,Jabara H,Yoon J,Galand C,Heesters BA,Burton OT,Mattoo H,Manis J,Geha RS

14-0031 was used in Functional assays to show that defective architectural cell function explains the immunodeficiency and poor outcome of HSCT in patients with IκBα deficiency.

Mon Feb 09 00:00:00 EST 2015

Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy.

Journal of the American Society of Nephrology : JASN

Cao Q,Wang Y,Wang XM,Lu J,Lee VW,Ye Q,Nguyen H,Zheng G,Zhao Y,Alexander SI,Harris DC

14-0031 was used in Flow cytometry/Cell sorting to identify the phenotype and function of renal mononuclear phagocytes expressing key markers of both macrophages and dendritic cells.

Sun Feb 01 00:00:00 EST 2015

Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.

Clinical cancer research : an official journal of the American Association for Cancer Research

Dai M,Yip YY,Hellstrom I,Hellstrom KE

14003182 was used in flow cytometry to test the efficacy of combining different monoclonal antibodies to treat cancer

Sun Mar 01 00:00:00 EST 2015

Distinct roles of β-cell mass and function during type 1 diabetes onset and remission.

Diabetes

Chmelova H,Cohrs CM,Chouinard JA,Petzold C,Kuhn M,Chen C,Roeder I,Kretschmer K,Speier S

14-0031 was used in Functional assays to demonstrate a major role of functional exhaustion and recovery of B-cells during T1D onset and remission.

Mon Jun 01 00:00:00 EDT 2015

T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis.

Frontiers in immunology

McPherson RC,Turner DG,Mair I,O'Connor RA,Anderton SM

14-0031 was used in Functional assays to report no difference in the resolution of experimental autoimmune encephalomyelitis in mice that lacked T-bet expression, compared to control mice.

Thu Mar 05 00:00:00 EST 2015

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.

eLife

Kumari S,Depoil D,Martinelli R,Judokusumo E,Carmona G,Gertler FB,Kam LC,Carman CV,Burkhardt JK,Irvine DJ,Dustin ML

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Wed Mar 11 00:00:00 EDT 2015

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.

eLife

Kumari S,Depoil D,Martinelli R,Judokusumo E,Carmona G,Gertler FB,Kam LC,Carman CV,Burkhardt JK,Irvine DJ,Dustin ML

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in T-Cell Activation

Wed Mar 11 00:00:00 EDT 2015

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.

Mucosal immunology

Jung Y,Wen T,Mingler MK,Caldwell JM,Wang YH,Chaplin DD,Lee EH,Jang MH,Woo SY,Seoh JY,Miyasaka M,Rothenberg ME

14-0031 was used in Flow cytometry/Cell sorting to show that eosinophils are required for mucosal production of IgA and development of Peyer's patches in the gut.

Wed Jul 01 00:00:00 EDT 2015

Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.

European journal of immunology

McAlees JW,Lajoie S,Dienger K,Sproles AA,Richgels PK,Yang Y,Khodoun M,Azuma M,Yagita H,Fulkerson PC,Wills-Karp M,Lewkowich IP

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of PD-1 family members in allergic asthma, showing differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis.

Wed Apr 01 00:00:00 EDT 2015

Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.

Molecular medicine (Cambridge, Mass.)

Li CH,Lin MH,Chu SH,Tu PH,Fang CC,Yen CH,Liang PI,Huang JC,Su YC,Sytwu HK,Chen YM

14-0031 was used in Western Blotting to investigate whether glycine N-methyltransferase plays an immunomodulatory role in the pathogenesis of experimental autoimmune encephalomyelitis.

Tue Mar 24 00:00:00 EDT 2015

A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.

Journal of leukocyte biology

Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W

14-0031 was used in Flow cytometry/Cell sorting to identify a novel Cd8 enhancer that directs expression in CD44(hi)CD62L(+) CD8(+) T cells, including innate-like and antigen-specific effector/memory CD8(+) T cells and in CD8αα(+) DCs.

Wed Apr 01 00:00:00 EDT 2015

Anti-herpes Activity of Vinegar-processed Daphne genkwa Flos Via Enhancement of Natural Killer Cell Activity.

Immune network

Uyangaa E,Choi JY,Ryu HW,Oh SR,Eo SK

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that enhanced resistance to HSV-1 infection by treatment with vp-genkwa is associated with NK cell activation.

Wed Apr 01 00:00:00 EDT 2015

Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.

Sat Aug 01 00:00:00 EDT 2015

MyD88 in macrophages is critical for abscess resolution in staphylococcal skin infection.

Journal of immunology (Baltimore, Md. : 1950)

Feuerstein R,Seidl M,Prinz M,Henneke P

14-0031 was used in Immunofluorescence to investigate how MyD88-dependent sensing of staphylococci by resident dermal Mφs is key for a rapid and balanced immune response, and PMLs are dependent on intact Mφ for full function.

Sun Mar 15 00:00:00 EDT 2015

Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Lobo PI,Schlegel KH,Bajwa A,Huang L,Kurmaeva E,Wang B,Ye H,Tedder TF,Kinsey GR,Okusa MD

14-0031 was used in Flow cytometry/Cell sorting to investigate how natural IgM anti-leukocyte Abs can switch BMDC to a regulatory phenotype despite the presence of LPS that ordinarily induces BMDC maturation.

Tue Dec 01 00:00:00 EST 2015

Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.

Journal of immunology (Baltimore, Md. : 1950)

Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS

14-0031 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.

Wed Jul 01 00:00:00 EDT 2015

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.

Integrative biology : quantitative biosciences from nano to macro

Lee JH,Dustin ML,Kam LC

14-0031 was used in Functional assays to investigate differences in cell response to micropatterned surfaces by conventional and regulatory T cells.

Sun Nov 01 00:00:00 EDT 2015

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.

Nature communications

Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Fri Dec 18 00:00:00 EST 2015

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.

Nature communications

Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Fri Dec 18 00:00:00 EST 2015

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.

Nature communications

Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Fri Dec 18 00:00:00 EST 2015

Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.

Nature communications

Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ

14-0031 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.

Wed Feb 18 00:00:00 EST 2015

An atlas of mouse CD4(+) T cell transcriptomes.

Biology direct

Stubbington MJ,Mahata B,Svensson V,Deonarine A,Nissen JK,Betz AG,Teichmann SA

14-0031 was used in Flow cytometry/Cell sorting to show that hundreds of genes are regulated purely by alternative splicing to extend our knowledge of the role of post-transcriptional regulation in cell differentiation.

Fri Apr 03 00:00:00 EDT 2015

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation.

PloS one

Derkow K,Krüger C,Dembny P,Lehnardt S

14-0031 was used in Flow cytometry/Cell sorting to investigate the crosstalk between γδ T cells and microglia activated by Toll-like receptors in the context of neuronal damage.

Tue May 17 00:00:00 EDT 2016

Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.

PloS one

Mandl M,Drechsler M,Jansen Y,Neideck C,Noels H,Faussner A,Soehnlein O,Weber C,Döring Y

14-0031 was used in Flow cytometry/Cell sorting to investigate how continuous diphtheria toxin-induced pDC depletion in Apoe-/- BDCA2-DTR mice receiving a high-fat diet (HFD) for 4 weeks did not alter lesion size or composition.

Sun May 08 00:00:00 EDT 2016

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Cell reports

Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8⁺ T-cell responses and immune memory.

Oncoimmunology

Wu J,Waxman DJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.

International journal of molecular sciences

Bittner S,Bobak N,Hofmann MS,Schuhmann MK,Ruck T,Göbel K,Brück W,Wiendl H,Meuth SG

14-0031 was used in Functional assays to investigate the effect of K2P5.1 knockout on T cells.

Fri Jul 24 00:00:00 EDT 2015

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Nature communications

Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR

14-0031 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.

Fri Jan 09 00:00:00 EST 2015

Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data.

BMC systems biology

Intosalmi J,Ahlfors H,Rautio S,Mannerstöm H,Chen ZJ,Lahesmaa R,Stockinger B,Lähdesmäki H

14-0031 was used in Functional assays to approve the important role of quantitative dynamic modeling in identifying and studying regulatory mechanisms.

Tue Nov 17 00:00:00 EST 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells.

PloS one

Schumann J,Stanko K,Schliesser U,Appelt C,Sawitzki B

14-0031 was used in Functional assays to investigate whether T helper cells differ in their CD44 expression and dependence on CD44 for differentiation.

Tue Apr 12 00:00:00 EDT 2016

Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice.

Journal of neuroinflammation

Djukic M,Sostmann N,Bertsch T,Mecke M,Nessler S,Manig A,Hanisch UK,Triebel J,Bollheimer LC,Sieber C,Nau R

14-0031 was used in Flow cytometry/Cell sorting to suggest a detrimental role of vitamin D deficiency in bacterial central nervous system infections.

Wed Jan 07 00:00:00 EST 2015

A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.

PloS one

Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue May 24 00:00:00 EDT 2016

CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.

European journal of microbiology & immunology

Milanez-Almeida P,Ulas T,Pasztoi M,Glage S,Schughart K,Lutz MB,Schultze JL,Huehn J

14-0031 was used in Flow cytometry/Cell sorting to study the involvement of CD11b(+)Ly6C(++)Ly6G(-) cells during inflammatory resolution following Influenza A virus infection.

Tue Dec 01 00:00:00 EST 2015

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.

BMC cancer

Gillgrass AE,Chew MV,Krneta T,Ashkar AA

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2015

Structure-based programming of lymph-node targeting in molecular vaccines.

Nature

Liu H,Moynihan KD,Zheng Y,Szeto GL,Li AV,Huang B,Van Egeren DS,Park C,Irvine DJ

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Thu Mar 27 00:00:00 EDT 2014

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Cell

Walch M,Dotiwala F,Mulik S,Thiery J,Kirchhausen T,Clayberger C,Krensky AM,Martinvalet D,Lieberman J

14-0031 was used in Functional assays to demonstrate that human killer lymphocytes protect against intracellular bacteria via a novel mechanism that utilises granzymes, granulysin, and perforin.

Thu Jun 05 00:00:00 EDT 2014

Function of a Foxp3 cis-element in protecting regulatory T cell identity.

Cell

Li X,Liang Y,LeBlanc M,Benner C,Zheng Y

14-0031 was used in Flow cytometry/Cell sorting to investigate whether mechanisms exist to actively protect cell identity in response to environmental cues that confer functional plasticity.

Thu Aug 14 00:00:00 EDT 2014

Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.

Circulation

Hilgendorf I,Theurl I,Gerhardt LM,Robbins CS,Weber GF,Gonen A,Iwamoto Y,Degousee N,Holderried TA,Winter C,Zirlik A,Lin HY,Sukhova GK,Butany J,Rubin BB,Witztum JL,Libby P,Nahrendorf M,Weissleder R,Swirski FK

14-0031 was used in Functional assays to investigate the role of innate response activator B cells in atherosclerosis.

Tue Apr 22 00:00:00 EDT 2014

Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.

Circulation

14-0031 was used in Functional assays to investigate the role of innate response activator B cells in atherosclerosis.

Tue Apr 22 00:00:00 EDT 2014

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells.

Nature immunology

Wang H,Geng J,Wen X,Bi E,Kossenkov AV,Wolf AI,Tas J,Choi YS,Takata H,Day TJ,Chang LY,Sprout SL,Becker EK,Willen J,Tian L,Wang X,Xiao C,Jiang P,Crotty S,Victora GD,Showe LC,Tucker HO,Erikson J,Hu H

14-0031 was used in Functional assays to investigate the role of Foxp1 in CD4(+) cells, showing that it is a critical negative regulator of the differentiation of follicular helper T cells.

Tue Jul 01 00:00:00 EDT 2014

Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.

The Journal of clinical investigation

Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J

14-0031 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.

Sun Jun 01 00:00:00 EDT 2014

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.

Science translational medicine

Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

The Journal of experimental medicine

Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR

14-0031 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.

Mon Jul 28 00:00:00 EDT 2014

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.

The EMBO journal

Jaworski M,Marsland BJ,Gehrig J,Held W,Favre S,Luther SA,Perroud M,Golshayan D,Gaide O,Thome M

14-0031 was used in Functional assays to investigate the effect of mutational inactivation of Malt1, showing that inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.

Mon Dec 01 00:00:00 EST 2014

Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.

Cancer research

Guéry L,Dubrot J,Lippens C,Brighouse D,Malinge P,Irla M,Pot C,Reith W,Waldburger JM,Hugues S

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of Ag-presenting CpG-activated pDCs in Th17 differentiation and antitumor immunity.

Sat Nov 15 00:00:00 EST 2014

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Genes & development

Gerhardt DM,Pajcini KV,D'altri T,Tu L,Jain R,Xu L,Chen MJ,Rentschler S,Shestova O,Wertheim GB,Tobias JW,Kluk M,Wood AW,Aster JC,Gimotty PA,Epstein JA,Speck N,Bigas A,Pear WS

14-0031 was used in Functional assays to describe additional functions for Notch1 in embryonic haematopoietic stem cell biology.

Sat Mar 15 00:00:00 EDT 2014

Gene targeting in NOD mouse embryos using zinc-finger nucleases.

Diabetes

Chen YG,Forsberg MH,Khaja S,Ciecko AE,Hessner MJ,Geurts AM

14-0031 was used in Flow cytometry/Cell sorting to investigate how to generate gene-targeted knockouts in a pure NOD background by using ZFNs without potential confounding factors introduced by contaminating genetic materials obtained from other strains.

Wed Jan 01 00:00:00 EST 2014

Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.

The Journal of infectious diseases

Vogelzang A,Perdomo C,Zedler U,Kuhlmann S,Hurwitz R,Gengenbacher M,Kaufmann SH

14-0031 was used in Flow cytometry/Cell sorting to investigate the T-cell population required for recombinant Bacillus Calmette-Guérin δureC::hly vaccine's enhanced protection against tuberculosis.

Mon Dec 15 00:00:00 EST 2014

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

PLoS pathogens

Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C

14-0031 was used in Flow cytometry/Cell sorting to study the contribution of a specific signalling pathway involved in fungal recognition by dendritic cells during immune responses to fungal pathogens.

Tue Jul 01 00:00:00 EDT 2014

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

PLoS pathogens

Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C

Tue Jul 01 00:00:00 EDT 2014

Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion.

European journal of immunology

Larsen J,Dall M,Antvorskov JC,Weile C,Engkilde K,Josefsen K,Buschard K

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.

European journal of immunology

Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T

14-0031 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.

Wed Oct 01 00:00:00 EDT 2014

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.

Immunology and cell biology

Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA

14-0031 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.

Sat Nov 01 00:00:00 EDT 2014

CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer.

Immunology and cell biology

Hart KM,Usherwood EJ,Berwin BL

14-0031 was used in Functional assays to investigate a novel nongranulocytic CX3CR1-negative myeloid population.

Tue Jul 01 00:00:00 EDT 2014

Suppressive oligodeoxynucleotides promote the generation of regulatory T cells by inhibiting STAT1 phosphorylation.

International immunopharmacology

Bode C,Wang J,Klinman DM

14-0031 was used in in vitro experiments to study the mechanism underlying the immunosuppressive activity of suppressive oligodeoxynucleotides.

Mon Dec 01 00:00:00 EST 2014

Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

Journal of immunology (Baltimore, Md. : 1950)

Yang CY,Li JP,Chiu LL,Lan JL,Chen DY,Chuang HC,Huang CY,Tan TH

14-0031 was used in Functional assays to study how DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation.

Sat Feb 15 00:00:00 EST 2014

Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

Journal of immunology (Baltimore, Md. : 1950)

Yang CY,Li JP,Chiu LL,Lan JL,Chen DY,Chuang HC,Huang CY,Tan TH

14-0031 was used in Functional assays to study how DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation.

Sat Feb 15 00:00:00 EST 2014

Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.

Journal of immunology (Baltimore, Md. : 1950)

Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J

14-0031 was used in Functional assays to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.

Tue Apr 01 00:00:00 EDT 2014

IL-18 enhances immunosuppressive responses by promoting differentiation into monocytic myeloid-derived suppressor cells.

Journal of immunology (Baltimore, Md. : 1950)

Lim HX,Hong HJ,Cho D,Kim TS

14-0031-82 was used in Flow Cytometry to study the role of IL-18 in mediating immunosuppression via specifically enhancing the differentiation and function of monocytic myeloid-derived suppressor cells.

Mon Dec 01 00:00:00 EST 2014

IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.

Journal of immunology (Baltimore, Md. : 1950)

Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K

14-0031 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.

Sat Mar 01 00:00:00 EST 2014

Leptin metabolically licenses T cells for activation to link nutrition and immunity.

Journal of immunology (Baltimore, Md. : 1950)

Saucillo DC,Gerriets VA,Sheng J,Rathmell JC,Maciver NJ

14-0031 was used in Functional assays to investigate mechanisms that link systemic nutrition to T cell function.

Wed Jan 01 00:00:00 EST 2014

Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Saunders AE,Shim YA,Johnson P

14-0031 was used in Flow cytometry/Cell sorting to demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation.

Mon Sep 15 00:00:00 EDT 2014

Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.

The Journal of pharmacology and experimental therapeutics

Glick GD,Rossignol R,Lyssiotis CA,Wahl D,Lesch C,Sanchez B,Liu X,Hao LY,Taylor C,Hurd A,Ferrara JL,Tkachev V,Byersdorfer CA,Boros L,Opipari AW

14-0031 was used in in vitro experiments to develop a model of T-cell metabolism relevant to activated lymphocytes in vivo.

Sat Nov 01 00:00:00 EDT 2014

APRIL mediates peritoneal B-1 cell homeostasis.

Immunology letters

Sindhava VJ,Scholz JL,Stohl W,Cancro MP

14-0031 was used in Flow cytometry/Cell sorting to assess the contribution of BLyS and other ligands to peritoneal B-1 cell maintenance.

Fri Aug 01 00:00:00 EDT 2014

rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study.

Gene therapy

Rocca CJ,Ur SN,Harrison F,Cherqui S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Immunofluorescence

Sun Jun 01 00:00:00 EDT 2014

Mouse Sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1.

Biology of reproduction

Campese AF,Grazioli P,de Cesaris P,Riccioli A,Bellavia D,Pelullo M,Padula F,Noce C,Verkhovskaia S,Filippini A,Latella G,Screpanti I,Ziparo E,Starace D

14-0031 was used in Flow cytometry/Cell sorting to investigate whether conditioned medium from primary mouse Sertoli cells is able and sufficient to induce Tregs.

Sat Mar 01 00:00:00 EST 2014

Role of IL-17 and TGF-β in peritoneal adhesion formation after surgical trauma.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Wang G,Wu K,Li W,Zhao E,Shi L,Wang J,Shuai X,Cai K,Lu X,Tao K,Wang G

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2015

Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor.

PloS one

Figueiredo CA,Drohomyrecky PC,McCarthy SD,Leontyev D,Ma XZ,Branch DR,Dunn SE

14-0031 was used in Functional assays to investigate the mechanism of action of intravenous immunoglobulin treatment for autoimmunity, showing that optimal attenuation requires an intact interleukin-11 receptor.

Fri Oct 23 00:00:00 EDT 2015

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.

Cell reports

Mahata B,Zhang X,Kolodziejczyk AA,Proserpio V,Haim-Vilmovsky L,Taylor AE,Hebenstreit D,Dingler FA,Moignard V,Göttgens B,Arlt W,McKenzie AN,Teichmann SA

14-0031 was used in Functional assays to demonstrate the production of the steroid pregnenolone by Th2 cells in vitro and in vivo in a helminth infection model.

Thu May 22 00:00:00 EDT 2014

C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.

PloS one

Norrie IC,Ohlsson E,Nielsen O,Hasemann MS,Porse BT

14-0031 was used in Flow cytometry/Cell sorting to investigate the potential of the transcription factor C/EBPα as a target for the alleviation of ageing/cancer-associated immunosenescence.

Tue Sep 16 00:00:00 EDT 2014

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Cell reports

Gewies A,Gorka O,Bergmann H,Pechloff K,Petermann F,Jeltsch KM,Rudelius M,Kriegsmann M,Weichert W,Horsch M,Beckers J,Wurst W,Heikenwalder M,Korn T,Heissmeyer V,Ruland J

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that targeted Malt1-paracaspase inactivation induces a lethal inflammatory syndrome with lymphocyte-dependent neurodegeneration.

Thu Nov 20 00:00:00 EST 2014

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.

PloS one

Leigh ND,Bian G,Ding X,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X

14-0031 was used in Flow cytometry/Cell sorting to assess the immunogenic capabilities of CBLB502, a toll-like receptor 5 agonist.

Wed Sep 17 00:00:00 EDT 2014

Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling.

PloS one

Sharir R,Semo J,Shimoni S,Ben-Mordechai T,Landa-Rouben N,Maysel-Auslender S,Shaish A,Entin-Meer M,Keren G,George J

14-0031 was used in Functional assays to indicate that Tregs may serve as potential interventional targets for attenuating left ventricular remodeling.

Wed Sep 16 00:00:00 EDT 2015

The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus.

PloS one

Costes LM,van der Vliet J,Farro G,Matteoli G,van Bree SH,Olivier BJ,Nolte MA,Boeckxstaens GE,Cailotto C

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that intestinal manipulation results in two distinct phenomena: local intestinal inflammation and a decrease in splenic cellularity.

Fri Nov 06 00:00:00 EST 2015

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.

PloS one

Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2015

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

PloS one

May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF

14-0031 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.

Mon Oct 19 00:00:00 EDT 2015

Activated macrophage survival is coordinated by TAK1 binding proteins.

PloS one

Mihaly SR,Morioka S,Ninomiya-Tsuji J,Takaesu G

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of TAB1 and TAB2 in macrophage survival.

Fri Jan 16 00:00:00 EST 2015

Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.

PloS one

Thelemann C,Eren RO,Coutaz M,Brasseit J,Bouzourene H,Rosa M,Duval A,Lavanchy C,Mack V,Mueller C,Reith W,Acha-Orbea H

14-0031 was used in Flow cytometry/Cell sorting to investigate how epithelial MHCII expression is induced and how a deficiency in inducible epithelial MHCII expression alters susceptibility to colitis and the outcome of colon-specific immune responses.

Mon Dec 22 00:00:00 EST 2014

The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model.

PloS one

Kobayashi S,Hara A,Isagawa T,Manabe I,Takeda K,MaruYama T

14-0031 was used in Functional assays to investigate the role of IκBNS in autoimmunity, showing that it influences the susceptibility to experimental autoimmune encephalomyelitis.

Fri Jun 26 00:00:00 EDT 2015

Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection.

Journal of neuroinflammation

Ribes S,Meister T,Ott M,Redlich S,Janova H,Hanisch UK,Nessler S,Nau R

14-0031 was used in Flow cytometry/Cell sorting to suggest that systemic administration of CpG ODN may help to prevent bacterial CNS infections in immunocompromised individuals.

Thu Jan 23 00:00:00 EST 2014

Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.

PloS one

Cao Y,Rathmell JC,Macintyre AN

14-0031 was used in Functional assays to compare activation-induced proliferation and metabolic reprogramming of CD4 and CD8 T cells.

Mon Nov 16 00:00:00 EST 2015

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

Nature

Roychoudhuri R,Hirahara K,Mousavi K,Clever D,Klebanoff CA,Bonelli M,Sciumè G,Zare H,Vahedi G,Dema B,Yu Z,Liu H,Takahashi H,Rao M,Muranski P,Crompton JG,Punkosdy G,Bedognetti D,Wang E,Hoffmann V,Rivera J,Marincola FM,Nakamura A,Sartorelli V,Kanno Y,Gattinoni L,Muto A,Igarashi K,O'Shea JJ,Restifo NP

14-0031 was used in Flow cytometry/Cell sorting to study the role of BACH2 in the regulation of immune cell activation and differentiation.

Thu Jun 27 00:00:00 EDT 2013

T cell factor 1 is required for group 2 innate lymphoid cell generation.

Immunity

Yang Q,Monticelli LA,Saenz SA,Chi AW,Sonnenberg GF,Tang J,De Obaldia ME,Bailis W,Bryson JL,Toscano K,Huang J,Haczku A,Pear WS,Artis D,Bhandoola A

14-0031 was used in Flow cytometry/Cell sorting to study group 2 innate lymphoid cell development.

Thu Apr 18 00:00:00 EDT 2013

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

Circulation

Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,Lutgens E,Wouters K,de Winther MP,Zacchigna S,Giacca M,van Bilsen M,Papageorgiou AP,Schroen B

14-0031 was used in Flow cytometry/Cell sorting to investigate the therapeutic effects of microRNA-155 manipulation in hypertensive heart disease.

Tue Sep 24 00:00:00 EDT 2013

Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

Cell host & microbe

Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH

14-0031 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.

Wed May 15 00:00:00 EDT 2013

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Nature immunology

Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB

14-0031 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.

Tue Jan 01 00:00:00 EST 2013

COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.

Blood

Yoshida A,Kato JY,Nakamae I,Yoneda-Kato N

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of COP1 in tumourigenesis.

Thu Sep 05 00:00:00 EDT 2013

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.

Blood

Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B

14-0031 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.

Thu Jun 27 00:00:00 EDT 2013

B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients.

Critical care (London, England)

Shubin NJ,Monaghan SF,Heffernan DS,Chung CS,Ayala A

14-0031 was used in Flow cytometry/Cell sorting to evaluate the role of B and T lymphocyte attenuator, an immune-regulatory receptor, in driving lymphocyte dysfunction and apoptosis during sepsis.

Fri Nov 29 00:00:00 EST 2013

Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung.

Brain, behavior, and immunity

Dugger KJ,Chrisman T,Jones B,Chastain P,Watson K,Estell K,Zinn K,Schwiebert L

14-0031 was used in Flow cytometry/Cell sorting to study how aerobic exercise training can reduce antigen specific Th cell migration into asthmatic lungs.

Fri Nov 01 00:00:00 EDT 2013

Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.

Kidney international

Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X

14-0031 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.

Sun Sep 01 00:00:00 EDT 2013

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.

The Journal of experimental medicine

Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L

14-0031 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.

Mon Feb 11 00:00:00 EST 2013

Antigen-coated poly α-hydroxy acid based microparticles for heterologous prime-boost adenovirus based vaccinations.

Biomaterials

Lemke CD,Geary SM,Joshi VB,Salem AK

14-0031 was used in Flow cytometry/Cell sorting to provide support for using poly α-hydroxy acid-based microparticles in prime-boost viral vaccination strategies geared toward the safer, and potentially more efficient, generation of anti-tumor immunity.

Fri Mar 01 00:00:00 EST 2013

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

The Journal of allergy and clinical immunology

Jabara HH,Ohsumi T,Chou J,Massaad MJ,Benson H,Megarbane A,Chouery E,Mikhael R,Gorka O,Gewies A,Portales P,Nakayama T,Hosokawa H,Revy P,Herrod H,Le Deist F,Lefranc G,Ruland J,Geha RS

14-0031 was used in Western Blotting to identify the genetic cause of combined immunodeficiency in 2 siblings, the products of a first-cousin marriage, who experienced recurrent bacterial and candidal infections with bronchiectasis, growth delay, and early death.

Mon Jul 01 00:00:00 EDT 2013

Aire deficiency promotes TRP-1-specific immune rejection of melanoma.

Cancer research

Zhu ML,Nagavalli A,Su MA

14-0031 was used in Flow cytometry/Cell sorting to show how Aire deficiency can enhance immune responses against melanoma and offer a logical strategy to enhance immune rejection of melanoma.

Mon Apr 01 00:00:00 EDT 2013

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.

Molecular therapy : the journal of the American Society of Gene Therapy

Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW

14-0031 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.

Fri Feb 01 00:00:00 EST 2013

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.

eLife

Heinrichs S,Conover LF,Bueso-Ramos CE,Kilpivaara O,Stevenson K,Neuberg D,Loh ML,Wu WS,Rodig SJ,Garcia-Manero G,Kantarjian HM,Look AT

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that low MYBL2 activity is the underlying cause of the expansion of haematopoietic progenitors in a large fraction of myeloid malignancies.

Tue Jul 16 00:00:00 EDT 2013

CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.

Mucosal immunology

Barnes MJ,Griseri T,Johnson AM,Young W,Powrie F,Izcue A

14-0031 was used in Functional assays to analyse the role of CTLA-4 in the peripheral induction of Treg cells in vitro and in vivo.

Fri Mar 01 00:00:00 EST 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis.

Clinical and experimental immunology

Wang J,Shan Y,Jiang Z,Feng J,Li C,Ma L,Jiang Y

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Host b7x promotes pulmonary metastasis of breast cancer.

Journal of immunology (Baltimore, Md. : 1950)

Abadi YM,Jeon H,Ohaegbulam KC,Scandiuzzi L,Ghosh K,Hofmeyer KA,Lee JS,Ray A,Gravekamp C,Zang X

14-0031 was used in Flow cytometry/Cell sorting to uncover the metastasis-promoting properties of the inhibitory T cell co-stimulatory molecule, B7x, and suggest the therapeutic potential of targeting its pathway during cancer immunotherapy.

Mon Apr 01 00:00:00 EDT 2013

Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Ryan SO,Johnson JL,Cobb BA

14-0031 was used in Flow cytometry/Cell sorting to reveal long-term persistence of an inflammation-associated neutrophil cell population constitutively producing IFN-γ.

Wed May 15 00:00:00 EDT 2013

Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Ryan SO,Johnson JL,Cobb BA

14-0031 was used in Flow cytometry/Cell sorting to reveal long-term persistence of an inflammation-associated neutrophil cell population constitutively producing IFN-γ.

Wed May 15 00:00:00 EDT 2013

CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.

Journal of immunology (Baltimore, Md. : 1950)

Frazer LC,Sullivan JE,Zurenski MA,Mintus M,Tomasak TE,Prantner D,Nagarajan UM,Darville T

14-0031 was used in Functional assays to assess the role of MyD88 in immune responses to Chlamydia infection.

Tue Oct 15 00:00:00 EDT 2013

Double-positive thymocytes select mucosal-associated invariant T cells.

Journal of immunology (Baltimore, Md. : 1950)

Seach N,Guerri L,Le Bourhis L,Mburu Y,Cui Y,Bessoles S,Soudais C,Lantz O

14-0031 was used in Functional assays to investigate the hematopoietic cell type responsible for MAIT cell selection.

Sun Dec 15 00:00:00 EST 2013

Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Baine I,Basu S,Ames R,Sellers RS,Macian F

14-0031 was used in an ELISA assay to identify that the transcription factor, Helios, maintains the anergic phenotype of Tregs by suppressing transcription of interleukin 2.

Fri Feb 01 00:00:00 EST 2013

Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ammann JU,Cooke A,Trowsdale J

14-0031 was used in Functional assays to investigate a role for butyrophilin-related protein, Btn2a2, in the modulation of T lymphocytes.

Wed May 15 00:00:00 EDT 2013

Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.

Journal of immunology (Baltimore, Md. : 1950)

Hou L,Jie Z,Desai M,Liang Y,Soong L,Wang T,Sun J

14-0031 was used in in vitro experiments to examine the interactions among the innate and adaptive immune components of the liver parenchyma during acute viral hepatitis.

Tue Jan 15 00:00:00 EST 2013

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells.

International immunology

Dillon TJ,Takahashi M,Li Y,Tavisala S,Murray SE,Moran AE,Parker DC,Stork PJ

14-0031 was used in Functional assays to assess the effects of ablation of B-Raf expression in thymocytes on ERK activation and thymocyte development.

Mon Apr 01 00:00:00 EDT 2013

Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.

Molecular and cellular biology

Zhong MC,Veillette A

14-0031 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.

Fri Mar 01 00:00:00 EST 2013

Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice.

Skeletal muscle

Ieronimakis N,Pantoja M,Hays AL,Dosey TL,Qi J,Fischer KA,Hoofnagle AN,Sadilek M,Chamberlain JS,Ruohola-Baker H,Reyes M

14-0031 was used in Immunohistochemistry to characterise the histopathological and functional effects of increasing SP1 levels in a mouse model of Duchenne muscular dystrophy.

Thu Aug 01 00:00:00 EDT 2013

Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD

14-0031 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.

Tue Jan 01 00:00:00 EST 2013

Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells.

Cellular immunology

Grishkan IV,Ntranos A,Calabresi PA,Gocke AR

14-0031 was used in Flow cytometry/Cell sorting to investigate whether double-negative T cells that accumulate in some autoimmune diseases can arise from hyper-stimulated pathogenic CD4+ T cells.

Thu Mar 20 00:00:00 EDT 2014

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.

Experimental hematology

Beachy SH,Onozawa M,Silverman D,Chung YJ,Rivera MM,Aplan PD

14-0031 was used in Flow cytometry/Cell sorting to delineate the role of the HOXA9 gene in malignant transformation using transgenic mice that overexpress Hoxa9 in haematopoietic tissues.

Sat Jun 01 00:00:00 EDT 2013

Copper-zinc superoxide dismutase-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein 35-55.

Journal of neuroimmunology

Massilamany C,Gangaplara A,Kim H,Stanford C,Rathnaiah G,Steffen D,Lee J,Reddy J

14-0031 was used in Functional assays to study the role of copper-zinc superoxide dismutase deficiency in the mediation of central nervous system autoimmunity.

Fri Mar 15 00:00:00 EDT 2013

The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.

The Journal of biological chemistry

Zhong MC,Veillette A

14-0031 was used in Flow cytometry/Cell sorting to investigate how SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types.

Fri Nov 01 00:00:00 EDT 2013

Requirement for core 2 O-glycans for optimal resistance to helminth infection.

PloS one

Mullaly SC,Oudhoff MJ,Min PH,Burrows K,Antignano F,Rattray DG,Chenery A,McNagny KM,Ziltener HJ,Zaph C

14-0031 was used in Functional assays to examine the role of specific chemokine receptors, adhesion molecules and glycosyltransferases in the development of protective immunity to Trichuris muris.

Mon Sep 30 00:00:00 EDT 2013

Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool.

PloS one

Nakamura K,White AJ,Parnell SM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

14-0031 was used in Flow cytometry/Cell sorting to reveal differences in the chemokine receptor requirements for intrathymic migration of αβ and invariant γδT-cells, and highlight a differential role for CCR4 in the maintenance, but not initial seeding, of DETC in the epidermis.

Thu May 08 00:00:00 EDT 2014

Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice.

Journal of cancer science & therapy

Zheng D,Chen H,Bartee MY,Williams J,Davids JA,Lomas DA,McFadden G,Lucas AR

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Aug 19 00:00:00 EDT 2013

Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.

Nature communications

Yao C,Hirata T,Soontrapa K,Ma X,Takemori H,Narumiya S

14-0031 was used in Functional assays to investigate the role of cAMP in Th1 differentiation, showing that prostaglandin E2 promotes differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.

Tue Oct 22 00:00:00 EDT 2013

T cells at the site of autoimmune inflammation show increased potential for trogocytosis.

PloS one

Haastert B,Mellanby RJ,Anderton SM,O'Connor RA

14-0031 was used in Magnetic cell separation to assess the suitability of trogocytosis detection to identify disease relevant effector and regulatory T cells during autoimmune inflammation.

Thu Sep 11 00:00:00 EDT 2014

Trogocytosis as a mechanistic link between chimerism and prenatal tolerance.

Chimerism

Alhajjat AM,Strong BS,Durkin ET,Turner LE,Wadhwani RK,Midura EF,Keswani SG,Shaaban AF

14-0031 was used in Flow cytometry/Cell sorting to investigate the mechanisms leading to NK cell tolerance in prenatal chimeras, showing trogocytosis as a mechanistic link between chimerism and prenatal tolerance.

Thu Nov 06 00:00:00 EST 2014

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.

Nature communications

Leyva-Castillo JM,Hener P,Michea P,Karasuyama H,Chan S,Soumelis V,Li M

14-0031 was used in Functional assays to investigate the mechanisms by which thymic stromal lymphopoietin leads to Th2 initiation, showing that it occurs through an orchestrated immune cascade.

Tue Oct 07 00:00:00 EDT 2014

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Immunity

Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA

14-0031 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.

Fri Sep 21 00:00:00 EDT 2012

Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells.

Immunity

Duffy D,Perrin H,Abadie V,Benhabiles N,Boissonnas A,Liard C,Descours B,Reboulleau D,Bonduelle O,Verrier B,Van Rooijen N,Combadière C,Combadière B

14-0031 was used in Immunocytochemistry to demonstrate how antigen is transported to the bone marrow, providing a source of virus-specific memory CD8+ T-cells.

Fri Nov 16 00:00:00 EST 2012

Molecular definition of the identity and activation of natural killer cells.

Nature immunology

Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL

14-0031 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.

Mon Oct 01 00:00:00 EDT 2012

OX40 signaling favors the induction of T(H)9 cells and airway inflammation.

Nature immunology

Xiao X,Balasubramanian S,Liu W,Chu X,Wang H,Taparowsky EJ,Fu YX,Choi Y,Walsh MC,Li XC

14-0031 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the induction of Th9 cells, with potential clinical implications in allergic inflammation.

Mon Oct 01 00:00:00 EDT 2012

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

Nature immunology

Takahashi H,Kanno T,Nakayamada S,Hirahara K,Sciumè G,Muljo SA,Kuchen S,Casellas R,Wei L,Kanno Y,O'Shea JJ

14-0031 was used in Functional assays to investigate the role of MicroRNAs on T cell plasticity, showing that TGF-β and retinoic acid induce miR-10a which targets Bcl-6 and constrains T helper plasticity.

Sun Apr 29 00:00:00 EDT 2012

Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy.

Blood

Tietze JK,Wilkins DE,Sckisel GD,Bouchlaka MN,Alderson KL,Weiss JM,Ames E,Bruhn KW,Craft N,Wiltrout RH,Longo DL,Lanier LL,Blazar BR,Redelman D,Murphy WJ

14-0031 was used in Functional assays to demonstrate that memory CD8(+) T cells can express differential phenotypes indicative of adaptive or innate effectors based on the nature of the stimuli.

Thu Mar 29 00:00:00 EDT 2012

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.

Blood

Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K

14-0031 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.

Thu Jun 14 00:00:00 EDT 2012

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.

Blood

Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of kruppel-like factor 7 in hematopoietic stem and progenitor cell function.

Thu Oct 11 00:00:00 EDT 2012

CD28 ligation increases macrophage suppression of T-cell proliferation.

Cellular & molecular immunology

Silberman D,Bucknum A,Bartlett T,Composto G,Kozlowski M,Walker A,Werda A,Cua J,Sharpe AH,Somerville JE,Riggs JE

14-0031 was used in Functional assays to investigate the ability of exogenous T-cell costimulation to recover the peritoneal T-cell response.

Sun Jul 01 00:00:00 EDT 2012

Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells.

Cancer research

Goldstein MJ,Kohrt HE,Houot R,Varghese B,Lin JT,Swanson E,Levy R

14-0031 was used in Functional assays to explore whether adoptive T-cell therapy is limited by cotransfer of Tregs, showing that cotransfer can be avoided through selection of CD4-expressing T cells and depletion of CD137-expressing Tregs.

Thu Mar 01 00:00:00 EST 2012

Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.

Molecular therapy : the journal of the American Society of Gene Therapy

Engels B,Chervin AS,Sant AJ,Kranz DM,Schreiber H

14-0031 was used in Functional assays to investigate the effect of genetic engineering TCRs for nanomolar affinity, showing long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing high affinity LCR.

Thu Mar 01 00:00:00 EST 2012

Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes.

Diabetologia

Baeke F,Van Belle TL,Takiishi T,Ding L,Korf H,Laureys J,Gysemans C,Mathieu C

14-0031 was used in Flow cytometry/Cell sorting to showcase a novel combination strategy for improving anti-CD3's therapeutic efficiency for reversing recent-onset type 1 diabetes.

Mon Oct 01 00:00:00 EDT 2012

Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes.

Diabetologia

Baeke F,Van Belle TL,Takiishi T,Ding L,Korf H,Laureys J,Gysemans C,Mathieu C

14-0031 was used in Flow cytometry/Cell sorting to showcase a novel combination strategy for improving anti-CD3's therapeutic efficiency for reversing recent-onset type 1 diabetes.

Mon Oct 01 00:00:00 EDT 2012

Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis.

Clinical immunology (Orlando, Fla.)

Lin JT,Stein EA,Wong MT,Kalpathy KJ,Su LL,Utz PJ,Robinson WH,Fathman CG

14-0031 was used in Functional assays to evaluate the signalling pathways utilised by naïve and experienced effector CD4 T cells during activation and proliferation.

Wed Feb 01 00:00:00 EST 2012

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.

Science signaling

Piao X,Komazawa-Sakon S,Nishina T,Koike M,Piao JH,Ehlken H,Kurihara H,Hara M,Van Rooijen N,Schütz G,Ohmuraya M,Uchiyama Y,Yagita H,Okumura K,He YW,Nakano H

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of c-Flip in postnatal intestine and liver development, showing that homeostasis is maintained by inhibiting apoptosis and programmed necrosis.

Tue Dec 18 00:00:00 EST 2012

Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major.

PLoS pathogens

Auderset F,Schuster S,Coutaz M,Koch U,Desgranges F,Merck E,MacDonald HR,Radtke F,Tacchini-Cottier F

14-0031 was used in Functional assays to investigate the role of Notch in Th1 cell differentiation following parasite infection.

Mon Jul 09 00:00:00 EDT 2012

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

PLoS pathogens

Hafalla JC,Claser C,Couper KN,Grau GE,Renia L,de Souza JB,Riley EM

14-0031 was used in an ELISA assay to investigate the differential and complex regulation that governs immune responses to malaria parasites.

Wed Feb 01 00:00:00 EST 2012

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

PLoS pathogens

Hafalla JC,Claser C,Couper KN,Grau GE,Renia L,de Souza JB,Riley EM

14-0031 was used in an ELISA assay to investigate the differential and complex regulation that governs immune responses to malaria parasites.

Wed Feb 01 00:00:00 EST 2012

TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice.

Journal of virology

Jeisy-Scott V,Kim JH,Davis WG,Cao W,Katz JM,Sambhara S

14-0031 was used in Flow cytometry/Cell sorting to demonstrate the important role that TLR7 plays in vaccine-induced humoral immune responses to influenza virus.

Mon Oct 01 00:00:00 EDT 2012

Donor- but not host-derived interleukin-10 contributes to the regulation of experimental graft-versus-host disease.

Journal of leukocyte biology

Tawara I,Sun Y,Liu C,Toubai T,Nieves E,Evers R,Alrubaie M,Mathewson N,Tamaki H,Reddy P

14-0031 was used in Functional assays to determine the functional relevance of the source of IL-10 and its role in the biology of acute graft-versus-host disease.

Sun Apr 01 00:00:00 EDT 2012

Pulmonary T cell activation in response to chronic particulate air pollution.

American journal of physiology. Lung cellular and molecular physiology

Deiuliis JA,Kampfrath T,Zhong J,Oghumu S,Maiseyeu A,Chen LC,Sun Q,Satoskar AR,Rajagopalan S

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Feb 15 00:00:00 EST 2012

A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Ding X,Bian G,Leigh ND,Qiu J,McCarthy PL,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X

14-0031 was used in Flow cytometry/Cell sorting to investigate the effect of CBLB502 on graft-versus-tumour activity.

Thu Nov 15 00:00:00 EST 2012

NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.

Journal of immunology (Baltimore, Md. : 1950)

Häcker H,Chi L,Rehg JE,Redecke V

14-0031 was used in Flow cytometry/Cell sorting to show that NF-κB-inducing kinase activity in non-haematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease.

Tue May 01 00:00:00 EDT 2012

CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.

Journal of immunology (Baltimore, Md. : 1950)

Wensveen FM,Unger PP,Kragten NA,Derks IA,ten Brinke A,Arens R,van Lier RA,Eldering E,van Gisbergen KP

14-0031 was used in Functional assays to investigate how BIm-dependent apoptosis is initiated in CD8 T cells.

Tue May 01 00:00:00 EDT 2012

Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Aksoylar HI,Lampe K,Barnes MJ,Plas DR,Hoebe K

14-0031 was used in Flow cytometry/Cell sorting to establish a novel link between Gimap5 and Foxo expression and provide evidence for a regulatory mechanism that controls Foxo protein expression and may help to maintain immunological tolerance.

Sun Jan 01 00:00:00 EST 2012

Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

American journal of physiology. Gastrointestinal and liver physiology

Ernst PB,Erickson LD,Loo WM,Scott KG,Wiznerowicz EB,Brown CC,Torres-Velez FJ,Alam MS,Black SG,McDuffie M,Feldman SH,Wallace JL,McKnight GW,Padol IT,Hunt RH,Tung KS

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2012

Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

American journal of physiology. Gastrointestinal and liver physiology

Ernst PB,Erickson LD,Loo WM,Scott KG,Wiznerowicz EB,Brown CC,Torres-Velez FJ,Alam MS,Black SG,McDuffie M,Feldman SH,Wallace JL,McKnight GW,Padol IT,Hunt RH,Tung KS

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

Infection and immunity

Kanistanon D,Powell DA,Hajjar AM,Pelletier MR,Cohen IE,Way SS,Skerrett SJ,Wang X,Raetz CR,Ernst RK

14-0031 was used in Flow cytometry/Cell sorting to study the pathogenic effects of LPS modifications at the lipid A component of a Francisella novicida mutant.

Thu Mar 01 00:00:00 EST 2012

Species-specific activity of glycolipid ligands for invariant NKT cells.

Chembiochem : a European journal of chemical biology

Dangerfield EM,Cheng JM,Knight DA,Weinkove R,Dunbar PR,Hermans IF,Timmer MS,Stocker BL

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Jun 18 00:00:00 EDT 2012

Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.

The Journal of biological chemistry

Rothbard JB,Kurnellas MP,Brownell S,Adams CM,Su L,Axtell RC,Chen R,Fathman CG,Robinson WH,Steinman L

14-0031 was used in Functional assays to explore the mechanisms underlying the therapeutic benefit conferred by the the small heat shock protein, αB-crystallin, in inflammatory disease.

Fri Mar 23 00:00:00 EDT 2012

Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes.

Oncotarget

Aizman E,Mor A,Levy A,George J,Kloog Y

14-0031 was used in Functional assays to investigate the effect of salirasib on brain tumour growth.

Wed Feb 01 00:00:00 EST 2012

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.

The Journal of biological chemistry

Badeaux AI,Yang Y,Cardenas K,Vemulapalli V,Chen K,Kusewitt D,Richie E,Li W,Bedford MT

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Jan 02 00:00:00 EST 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Dendritic cells control CD4+CD25+ Treg cell suppressor function in vitro through juxtacrine delivery of IL-2.

PloS one

Kulhankova K,Rouse T,Nasr ME,Field EH

14-0031 was used in Flow cytometry/Cell sorting to establish the exogenous source of IL-2 that is required by Tregs for their expansion and suppressive function.

Tue Mar 12 00:00:00 EDT 2013

Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.

Immunity

Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A

14-0031 was used in Functional assays to investigate the molecular mechanisms by which TGF-beta allows Th17 cell differentiation via Smad-independent mechanisms.

Fri May 27 00:00:00 EDT 2011

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.

Nature immunology

Islam SA,Chang DS,Colvin RA,Byrne MH,McCully ML,Moser B,Lira SA,Charo IF,Luster AD

14-0031 was used in Functional assays to investigate the biological activity of CCL8, showing that it promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.

Tue Feb 01 00:00:00 EST 2011

GM-CSF in the lung protects against lethal influenza infection.

American journal of respiratory and critical care medicine

Huang FF,Barnes PF,Feng Y,Donis R,Chroneos ZC,Idell S,Allen T,Perez DR,Whitsett JA,Dunussi-Joannopoulos K,Shams H

14-0031 was used in Flow cytometry/Cell sorting to determine if increased expression of granulocyte/macrophage colony-stimulating factor in the lung increases resistance to influenza.

Fri Jul 15 00:00:00 EDT 2011

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.

Blood

Mayol K,Biajoux V,Marvel J,Balabanian K,Walzer T

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of CXCR4 and S1P5 in natural killer cell trafficking.

Thu Nov 03 00:00:00 EDT 2011

Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.

Blood

Jessen B,Maul-Pavicic A,Ufheil H,Vraetz T,Enders A,Lehmberg K,Längler A,Gross-Wieltsch U,Bay A,Kaya Z,Bryceson YT,Koscielniak E,Badawy S,Davies G,Hufnagel M,Schmitt-Graeff A,Aichele P,Zur Stadt U,Schwarz K,Ehl S

14-0031 was used in Flow cytometry/Cell sorting to suggest that differences in cytotoxic capacity of CTLs may indicate the risk of Chediak-Higashi syndrome patients to develop hemophagocytic lymphohistiocytosis.

Thu Oct 27 00:00:00 EDT 2011

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.

The Journal of experimental medicine

Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ

14-0031 was used in in vitro experiments to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.

Mon Mar 14 00:00:00 EDT 2011

Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4(+) and CD8(+) T cells.

Cancer research

González-Martín A,Gómez L,Lustgarten J,Mira E,Mañes S

14-0031 was used in Flow cytometry/Cell sorting to investigate the relevance of the chemokine receptor CCR5 in tumoural immune control.

Mon Aug 15 00:00:00 EDT 2011

Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells.

Cancer research

Zhang T,Sentman CL

14-0031 was used in Flow cytometry/Cell sorting to investigate of a new approach to selectively activate a T-cell attack against tumor cells.

Tue Mar 15 00:00:00 EDT 2011

Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells.

Diabetes

Muller YD,Golshayan D,Ehirchiou D,Wyss JC,Giovannoni L,Meier R,Serre-Beinier V,Puga Yung G,Morel P,Bühler LH,Seebach JD

14-0031 was used in Functional assays to evaluate how STZ-induced diabetes affects adaptive immunity and the consequences thereof on allograft rejection.

Thu Sep 01 00:00:00 EDT 2011

TSLP enhances the function of helper type 2 cells.

European journal of immunology

Kitajima M,Lee HC,Nakayama T,Ziegler SF

14-0031 was used in Functional assays to investigate the direct effect of TSLP on effector T cells.

Fri Jul 01 00:00:00 EDT 2011

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.

European journal of immunology

Goudy KS,Johnson MC,Garland A,Li C,Samulski RJ,Wang B,Tisch R

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of IL-2 in the regulation of FoxP3(+) T reg cells in NOD mice.

Sun May 01 00:00:00 EDT 2011

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.

European journal of immunology

Goudy KS,Johnson MC,Garland A,Li C,Samulski RJ,Wang B,Tisch R

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of IL-2 in the regulation of FoxP3(+) T reg cells in NOD mice.

Sun May 01 00:00:00 EDT 2011

Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.

Journal of immunology (Baltimore, Md. : 1950)

Freeman SA,Lei V,Dang-Lawson M,Mizuno K,Roskelley CD,Gold MR

14-0031 was used in Functional assays to identify factors critical for the early cytoskeletal changes and BCR reorganisation that are involved in APC-dependent lymphocyte activation.

Thu Dec 01 00:00:00 EST 2011

Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.

Journal of immunology (Baltimore, Md. : 1950)

Tabbekh M,Franciszkiewicz K,Haouas H,Lécluse Y,Benihoud K,Raman C,Mami-Chouaib F

14-0031-86 was used in Flow Cytometry to compare the T cell response to the B16F10 melanoma engrafted into CD5-deficient and wild-type C57BL/6 mice.

Fri Jul 01 00:00:00 EDT 2011

Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis.

Journal of immunology (Baltimore, Md. : 1950)

Trandem K,Zhao J,Fleming E,Perlman S

14-0031 was used in Functional assays to investigate the role of IL-10 in coronavirus-induced encephalitis.

Tue Mar 15 00:00:00 EDT 2011

NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Lee IF,van den Elzen P,Tan R,Priatel JJ

14-0031 was used in Flow cytometry/Cell sorting to elucidate roles for NKT cells in the adjuvant-promoting effects of CFA on innate and adaptive immunity.

Thu Sep 15 00:00:00 EDT 2011

Differential expression of NLRP3 among hematopoietic cells.

Journal of immunology (Baltimore, Md. : 1950)

Guarda G,Zenger M,Yazdi AS,Schroder K,Ferrero I,Menu P,Tardivel A,Mattmann C,Tschopp J

14-0031 was used in Flow cytometry/Cell sorting to characterize NOD-like receptor pyrin domain 3 (NLRP3) expression due to importance in health and disease.

Tue Feb 15 00:00:00 EST 2011

Apolipoprotein B binding domains: evidence that they are cell-penetrating peptides that efficiently deliver antigenic peptide for cross-presentation of cytotoxic T cells.

Journal of immunology (Baltimore, Md. : 1950)

Sakamoto N,Rosenberg AS

14-0031 was used in Magnetic cell separation to develop a vaccine strategy in which immunogens are tagged to ApoB-100 LDL receptor binding sites, and assess its therapeutic potential in a tumour setting.

Fri Apr 15 00:00:00 EDT 2011

The plasticity of regulatory T cell function.

Journal of immunology (Baltimore, Md. : 1950)

Pillai MR,Collison LW,Wang X,Finkelstein D,Rehg JE,Boyd K,Szymczak-Workman AL,Doggett T,Griffith TS,Ferguson TA,Vignali DA

14-0031 was used in Functional assays to investigate functional capacity of Tregs lacking the ability to secrete both IL-10 and IL-3.

Tue Nov 15 00:00:00 EST 2011

Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.

Biology of reproduction

Meng J,Greenlee AR,Taub CJ,Braun RE

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2011

Peritoneal T lymphocyte regulation by macrophages.

Immunobiology

Composto G,Gonzalez D,Bucknum A,Silberman D,Taylor J,Kozlowski M,Bloomfield T,Bartlett T,Riggs J

14-0031 was used in Functional assays to reveal a potential role for X-linked immunodeficiency in shaping macrophage-mediated immune regulation.

Mon Jul 18 00:00:00 EDT 2011

CD8 T-cell activation in mice injected with a plasmid DNA vaccine encoding AMA-1 of the reemerging Korean Plasmodium vivax.

The Korean journal of parasitology

Kim HJ,Jung BK,Lee JJ,Pyo KH,Kim TY,Choi BI,Kim TW,Hisaeda H,Himeno K,Shin EH,Chai JY

14-0031 was used in Flow cytometry/Cell sorting to study the cellular immunogenicity of a plasmid DNA vaccine - encoding AMA-1 of Plasmodium vivax - to mice.

Tue Mar 01 00:00:00 EST 2011

Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice.

PloS one

Pasieka TJ,Collins L,O'Connor MA,Chen Y,Parker ZM,Berwin BL,Piwnica-Worms DR,Leib DA

14-0031 was used in Flow cytometry/Cell sorting to examine HSV-1 pathogenesis in Stat1(-/-) mice and in IFNαβγR(-/-) mice, showing divergent viral pathogenesis between mouse strains.

Tue Feb 14 00:00:00 EST 2012

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.

PloS one

Qin H,Suzuki K,Nakata M,Chikuma S,Izumi N,Huong le T,Maruya M,Fagarasan S,Busslinger M,Honjo T,Nagaoka H

14-0031 was used in Functional assays to investigate the role of activation-induced cytidine deaminase in T cells, showing that expression is associated with a unique IL-10-producing subset that increases with age.

Mon May 21 00:00:00 EDT 2012

Critical role of TCF-1 in repression of the IL-17 gene.

PloS one

Ma J,Wang R,Fang X,Ding Y,Sun Z

14-0031 was used in Flow cytometry/Cell sorting to show that TCF-1 is a critical factor to repress the IL-17 gene by chromatin modifications during T cell development.

Tue Feb 28 00:00:00 EST 2012

Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis.

PloS one

Vaknin I,Kunis G,Miller O,Butovsky O,Bukshpan S,Beers DR,Henkel JS,Yoles E,Appel SH,Schwartz M

14-0031 was used in Functional assays to establish circulating MDSCs as a novel target for therapeutic intervention in ALS, at least at the early stage.

Mon Mar 26 00:00:00 EDT 2012

A role for IL-27p28 as an antagonist of gp130-mediated signaling.

Nature immunology

Stumhofer JS,Tait ED,Quinn WJ,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA

14-0031 was used in in vitro experiments to indicate a role for IL-27p28 as an antagonist of gp130-mediated signaling.

Wed Dec 01 00:00:00 EST 2010

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Nature immunology

Berger M,Krebs P,Crozat K,Li X,Croker BA,Siggs OM,Popkin D,Du X,Lawson BR,Theofilopoulos AN,Xia Y,Khovananth K,Moresco EM,Satoh T,Takeuchi O,Akira S,Beutler B

14-0031 was used in Flow cytometry/Cell sorting to investigate a new mutation in Slfn2, which causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Thu Apr 01 00:00:00 EDT 2010

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Nature immunology

Berger M,Krebs P,Crozat K,Li X,Croker BA,Siggs OM,Popkin D,Du X,Lawson BR,Theofilopoulos AN,Xia Y,Khovananth K,Moresco EM,Satoh T,Takeuchi O,Akira S,Beutler B

14-0031 was used in Flow cytometry/Cell sorting to investigate a new mutation in Slfn2, which causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Thu Apr 01 00:00:00 EDT 2010

CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.

Nature immunology

Barral P,Polzella P,Bruckbauer A,van Rooijen N,Besra GS,Cerundolo V,Batista FD

14-0031 was used in Flow cytometry/Cell sorting to investigate how and where invariant natural killer T cells encounter antigens in vivo.

Thu Apr 01 00:00:00 EDT 2010

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.

American journal of respiratory and critical care medicine

Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ

14-0031 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.

Tue Jun 15 00:00:00 EDT 2010

Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant.

Blood

Freire T,Zhang X,Dériaud E,Ganneau C,Vichier-Guerre S,Azria E,Launay O,Lo-Man R,Bay S,Leclerc C

14-0031 was used in Flow cytometry/Cell sorting to study dendritic cell antigen uptake and presentation by targeting the antigen receptor, macrophage galactose-type lectin (MGL), with tumor-associated Tn antigens.

Thu Nov 04 00:00:00 EDT 2010

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.

The Journal of experimental medicine

Lehnertz B,Northrop JP,Antignano F,Burrows K,Hadidi S,Mullaly SC,Rossi FM,Zaph C

14-0031 was used in Functional assays to investigate whether G9a plays a similar role in adult cells as it does during embryonic stem cell differentiation.

Mon May 10 00:00:00 EDT 2010

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent.

The Journal of experimental medicine

Wilson MS,Madala SK,Ramalingam TR,Gochuico BR,Rosas IO,Cheever AW,Wynn TA

14-0031 was used in in vitro experiments to study the inflammatory responses that precede and concur with collagen deposition in pulmonary fibrosis using three distinct models.

Mon Mar 15 00:00:00 EDT 2010

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent.

The Journal of experimental medicine

Wilson MS,Madala SK,Ramalingam TR,Gochuico BR,Rosas IO,Cheever AW,Wynn TA

14-0031 was used in in vitro experiments to study the inflammatory responses that precede and concur with collagen deposition in pulmonary fibrosis using three distinct models.

Mon Mar 15 00:00:00 EDT 2010

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

Clinical cancer research : an official journal of the American Association for Cancer Research

Mitsui J,Nishikawa H,Muraoka D,Wang L,Noguchi T,Sato E,Kondo S,Allison JP,Sakaguchi S,Old LJ,Kato T,Shiku H

14-0031 was used in Flow cytometry/Cell sorting to explore the use of anti-CTLA-4/anti-GITR mAb combination treatment to reject established tumours.

Sat May 15 00:00:00 EDT 2010

Overexpression of survivin initiates hematologic malignancies in vivo.

Leukemia

Small S,Keerthivasan G,Huang Z,Gurbuxani S,Crispino JD

14-0031 was used in Functional assays to investigate the extent to which survivin contributes to the initiation of tumours, showing that overexpression initiates hematologic malignancies.

Mon Nov 01 00:00:00 EDT 2010

Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.

Aging cell

Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C

14-0031 was used in in vitro experiments to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.

Fri Oct 01 00:00:00 EDT 2010

L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Carlson MJ,Fulton LM,Coghill JM,West ML,Burgents JE,Wan Y,Panoskaltsis-Mortari A,Tedder TF,Blazar BR,Serody JS

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that the adhesion molecule CD62L was dispensable for Treg-mediated protection from graft-versus-host disease.

Wed Dec 01 00:00:00 EST 2010

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.

Obesity (Silver Spring, Md.)

Strissel KJ,DeFuria J,Shaul ME,Bennett G,Greenberg AS,Obin MS

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2010

Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

PLoS pathogens

Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS

14-0031 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.

Fri Mar 19 00:00:00 EDT 2010

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.

Journal of molecular medicine (Berlin, Germany)

Polansky JK,Schreiber L,Thelemann C,Ludwig L,Krüger M,Baumgrass R,Cording S,Floess S,Hamann A,Huehn J

14-0031 was used in Flow cytometry/Cell sorting to demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network.

Fri Oct 01 00:00:00 EDT 2010

Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation.

Journal of immunology (Baltimore, Md. : 1950)

Carr EL,Kelman A,Wu GS,Gopaul R,Senkevitch E,Aghvanyan A,Turay AM,Frauwirth KA

14-0031 was used in in vitro experiments to study the role of amino acid metabolism in T cell activation.

Thu Jul 15 00:00:00 EDT 2010

Differential geminin requirement for proliferation of thymocytes and mature T cells.

Journal of immunology (Baltimore, Md. : 1950)

Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S

14-0031 was used in Functional assays to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.

Mon Mar 01 00:00:00 EST 2010

Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Brown MN,Fintushel SR,Lee MH,Jennrich S,Geherin SA,Hay JB,Butcher EC,Debes GF

14-0031 was used in Functional assays to investigate the dynamics and mechanisms of T cell exit from inflamed tissues, showing that requirements change during the course of inflammation.

Fri Oct 15 00:00:00 EDT 2010

IL-7 is essential for homeostatic control of T cell metabolism in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Jacobs SR,Michalek RD,Rathmell JC

14-0031 was used in Functional assays to investigate the role of metabolism and the specific growth factors essential to maintain metabolism of mature T cells in vivo.

Thu Apr 01 00:00:00 EDT 2010

Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit.

Journal of immunology (Baltimore, Md. : 1950)

DeNucci CC,Pagán AJ,Mitchell JS,Shimizu Y

14-0031 was used in Functional assays to investigate the role of the beta 1 subunit of integrin on CD4 T cell homing.

Mon Mar 01 00:00:00 EST 2010

Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.

Journal of immunology (Baltimore, Md. : 1950)

Henry T,Kirimanjeswara GS,Ruby T,Jones JW,Peng K,Perret M,Ho L,Sauer JD,Iwakura Y,Metzger DW,Monack DM

14-0031 was used in Flow cytometry/Cell sorting to determine that type I IFN signalling might contribute to the resistance of mice to infection with other intracellular bacteria.

Thu Apr 01 00:00:00 EDT 2010

Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo.

Journal of immunology (Baltimore, Md. : 1950)

O'Connor RA,Leech MD,Suffner J,Hämmerling GJ,Anderton SM

14-0031 was used in Flow cytometry/Cell sorting to assess the capacity for proinflammatory function of inducible regulatory T cells cells in vivo.

Wed Dec 15 00:00:00 EST 2010

Role of Cdk4 in lymphocyte function and allergen response.

Cell cycle (Georgetown, Tex.)

Chow YH,Zhu XD,Liu L,Schwartz BR,Huang XZ,Harlan JM,Schnapp LM

14-0031 was used in Functional assays to characterise the development and function of hematopoietic cells in Cdk4(-/-) mice and to assess the response of Cdk4(-/-) mice to allergen challenge.

Wed Dec 15 00:00:00 EST 2010

Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.

Journal of biomedicine & biotechnology

Xu X,Wen X,Chi Y,He L,Zhou S,Wang X,Zhao J,Liu F,Su C

14-0031 was used in Functional assays to suggest that Th1 or Th2 cell apoptosis is preferentially induced by different schistosome antigens during different stages of infection.

Thu Apr 01 00:00:00 EDT 2010

Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.

PloS one

Muller YD,Mai G,Morel P,Serre-Beinier V,Gonelle-Gispert C,Yung GP,Ehirchiou D,Wyss JC,Bigenzahn S,Irla M,Heusser C,Golshayan D,Seebach JD,Wekerle T,Bühler LH

14-0031 was used in Functional assays to investigate the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival, showing that it induces T regulatory cell mediated tolerance.

Mon Apr 26 00:00:00 EDT 2010

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Gastroenterology

Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2009

Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.

Gastroenterology

Tang L,Yang J,Liu W,Tang X,Chen J,Zhao D,Wang M,Xu F,Lu Y,Liu B,Sun Q,Zhang L,He F

14-0031 was used in Functional assays to investigate the molecular basis of immune suppression in the liver.

Thu Oct 01 00:00:00 EDT 2009

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression.

The Journal of clinical investigation

Taylor JJ,Krawczyk CM,Mohrs M,Pearce EJ

14-0031 was used in Functional assays to indicate that the decline in Th2 cell responsiveness during chronic schistosomiasis is the net result of the upregulation of GRAIL expression in response to repeated Ag stimulation.

Wed Apr 01 00:00:00 EDT 2009

Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.

The Journal of clinical investigation

Bedoret D,Wallemacq H,Marichal T,Desmet C,Quesada Calvo F,Henry E,Closset R,Dewals B,Thielen C,Gustin P,de Leval L,Van Rooijen N,Le Moine A,Vanderplasschen A,Cataldo D,Drion PV,Moser M,Lekeux P,Bureau F

14-0031 was used in Functional assays to reveal a crucial role for IMs in maintaining immune homeostasis in the respiratory tract.

Tue Dec 01 00:00:00 EST 2009

Tracking epitope-specific T cells.

Nature protocols

Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2009

In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells.

Cancer research

Scarlett UK,Cubillos-Ruiz JR,Nesbeth YC,Martinez DG,Engle X,Gewirtz AT,Ahonen CL,Conejo-Garcia JR

14-0031 was used in Immunohistochemistry to investigate whether the tolerogenic phenotype of ovarian tumour-infiltrating dendritic cells can be reversed in vivo to elicit therapeutically effective antitumour immunity.

Tue Sep 15 00:00:00 EDT 2009

Origins and functional basis of regulatory CD11c+CD8+ T cells.

European journal of immunology

Vinay DS,Kim CH,Choi BK,Kwon BS

14-0031 was used in Functional assays to elucidate the development of a novel CD11c(+)CD8(+) T cell subpopulation and the molecular basis of their suppressive function.

Mon Jun 01 00:00:00 EDT 2009

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

Journal of immunology (Baltimore, Md. : 1950)

Lin JT,Lineberry NB,Kattah MG,Su LL,Utz PJ,Fathman CG,Wu L

14-0031 was used in Functional assays to investigate the role of GRAIL in CD4 T cells, showing that proliferation is controlled by mTOR regulation of GRAIL expression.

Fri May 15 00:00:00 EDT 2009

CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.

Journal of immunology (Baltimore, Md. : 1950)

Vazquez BN,Laguna T,Carabana J,Krangel MS,Lauzurica P

14-0031 was used in Functional assays to investigate the molecular mechanism underlying mouse CD69 gene transcription in vivo in T and B cells, showing it is is differentially regulated.

Sun Nov 15 00:00:00 EST 2009

Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Ohno T,Oboki K,Kajiwara N,Morii E,Aozasa K,Flavell RA,Okumura K,Saito H,Nakae S

14-0031 was used in Functional assays to investigate the immune source of IL-33.

Tue Dec 15 00:00:00 EST 2009

Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.

Journal of immunology (Baltimore, Md. : 1950)

Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP

14-0031 was used in Flow cytometry/Cell sorting to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.

Sun Nov 15 00:00:00 EST 2009

Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.

Journal of immunology (Baltimore, Md. : 1950)

Graham KL,Zabel BA,Loghavi S,Zuniga LA,Ho PP,Sobel RA,Butcher EC

14-0031 was used in Flow cytometry/Cell sorting to investigate the involvement of chemokine-like receptor-1 in experimental autoimmune encephalomyelitis.

Sun Nov 15 00:00:00 EST 2009

Cutting Edge: Importance of IL-6 and cooperation between innate and adaptive immune receptors in cellular vaccination with B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Vanden Bush TJ,Buchta CM,Claudio J,Bishop GA

14-0031 was used in Magnetic cell separation to reveal alternative stimulation strategies for the production of effective Bvac and identify a key role for IL-6 in B cell Ag presentation and cellular vaccines.

Thu Oct 15 00:00:00 EDT 2009

Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.

Journal of immunology (Baltimore, Md. : 1950)

Kovalovsky D,Yu Y,Dose M,Emmanouilidou A,Konstantinou T,Germar K,Aghajani K,Guo Z,Mandal M,Gounari F

14-0031-82 was used in Flow Cytometry to report that beta-catenin/Tcf signalling was activated in double-positive thymocytes in response to alphabetaTCR engagement and impacted thymocyte selection.

Tue Sep 15 00:00:00 EDT 2009

NKG2A inhibits invariant NKT cell activation in hepatic injury.

Journal of immunology (Baltimore, Md. : 1950)

Kawamura T,Takeda K,Kaneda H,Matsumoto H,Hayakawa Y,Raulet DH,Ikarashi Y,Kronenberg M,Yagita H,Kinoshita K,Abo T,Okumura K,Smyth MJ

14-0031 was used in Flow cytometry/Cell sorting to investigate the role of NK cell receptors in iNKT cell activation, showing that NKG2A-mediated signalling negatively regulated iNKT activation and hepatic injury.

Thu Jan 01 00:00:00 EST 2009

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.

Journal of immunology (Baltimore, Md. : 1950)

Lahl K,Mayer CT,Bopp T,Huehn J,Loddenkemper C,Eberl G,Wirnsberger G,Dornmair K,Geffers R,Schmitt E,Buer J,Sparwasser T

14-0031 was used in Functional assays to investigate whether nonfunctional Tregs carrying self-reactive T cell receptors contribute to scurfy pathogenesis.

Sun Nov 01 00:00:00 EDT 2009

Hydrolysis of tumor cell lipids after CTL-mediated death.

International immunology

Alves B,Leong J,Tamang DL,Elliott V,Lowe M,Hudig D

14-0031 was used in Functional assays to evaluate IL-2 and IL-4 induced CTLs for hydrolysis of target cell lipids and killing.

Fri May 01 00:00:00 EDT 2009

Nylon wool purification alters the activation of T cells.

Molecular immunology

Wohler JE,Barnum SR

14-0031 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.

Sun Feb 01 00:00:00 EST 2009

Role of regulatory T cells in coronavirus-induced acute encephalitis.

Virology

Anghelina D,Zhao J,Trandem K,Perlman S

14-0031 was used in Flow cytometry/Cell sorting to show that Tregs may help to limit immunopathological disease without delaying virus clearance in coronavirus-induced acute encephalitis.

Sun Mar 15 00:00:00 EDT 2009

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry.

Journal of immunological methods

Fu G,Gascoigne NR

14-0031 was used in Flow cytometry/Cell sorting to present an improved method to measure calcium flux that allows different lymphocyte populations to be tested in the same sample.

Sat Oct 31 00:00:00 EDT 2009

Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum.

FEMS immunology and medical microbiology

Moniz RJ,Chan AM,Kelly KA

14-0031 was used in Immunofluorescence on frozen tissues to report the activation of classical CD11b+ (cDC) and plasmacytoid (pDC) during genital infection with Chlamydia muridarum.

Sun Mar 01 00:00:00 EST 2009

Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model.

FEMS immunology and medical microbiology

Shimazaki K,Chan AM,Moniz RJ,Wadehra M,Nagy A,Coulam CP,Mareninov S,Lepin EM,Wu AM,Kelly KA,Braun J,Gordon LK

14-0031 was used in Flow cytometry/Cell sorting to support EMP2 as a potential preventative and therapeutic target for genital chlamydial infection in vivo.

Sun Mar 01 00:00:00 EST 2009

A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.

Cell research

Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N

14-0031 was used in Flow cytometry/Cell sorting to investigate the role that IFNγ plays in mesenchymal stem cell mediated suppression of T cell proliferation.

Fri Aug 01 00:00:00 EDT 2008

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease.

Nature immunology

Hadeiba H,Sato T,Habtezion A,Oderup C,Pan J,Butcher EC

14-0031 was used in in vitro experiments to identify a highly immunosuppressive population of pDCs present in lymphoid tissues.

Sat Nov 01 00:00:00 EDT 2008

Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.

The Journal of experimental medicine

Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A

14-0031 was used in Flow cytometry/Cell sorting to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.

Mon Dec 22 00:00:00 EST 2008

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.

Hepatology (Baltimore, Md.)

You Q,Cheng L,Kedl RM,Ju C

14-0031 was used in Functional assays to examine the ability of Kupffer cells to present antigens and to suppress T cell activation by splenic dendritic cells.

Mon Sep 01 00:00:00 EDT 2008

Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses.

Cancer research

Caserta S,Alessi P,Guarnerio J,Basso V,Mondino A

14-0031 was used in Flow cytometry/Cell sorting to support the use of cell-free, synthetic aAPC as a specific and versatile alternative to expand peptide-specific CD4(+) T cells in adoptive and active immunotherapy.

Tue Apr 15 00:00:00 EDT 2008

Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice.

Proceedings of the National Academy of Sciences of the United States of America

Huai J,Firat E,Nil A,Million D,Gaedicke S,Kanzler B,Freudenberg M,van Endert P,Kohler G,Pahl HL,Aichele P,Eichmann K,Niedermann G

14-0031 was used in in vitro experiments to investigate the functions of the cytosolic protease tripeptidyl peptidase II in normal cellular and systemic physiology using TPPII-deficient mice.

Tue Apr 01 00:00:00 EDT 2008

Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus.

Journal of virology

Castilow EM,Olson MR,Meyerholz DK,Varga SM

14-0031 was used in Functional assays to compare the immune response elicited by the G versus F protein of the respiratory syncytial virus, showing a differential role of gamma interferon.

Sat Mar 01 00:00:00 EST 2008

Unique receptor repertoire in mouse uterine NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F

14-0031-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.

Sat Nov 01 00:00:00 EDT 2008

Involvement of Sema4A in the progression of experimental autoimmune myocarditis.

FEBS letters

Makino N,Toyofuku T,Takegahara N,Takamatsu H,Okuno T,Nakagawa Y,Kang S,Nojima S,Hori M,Kikutani H,Kumanogoh A

14-0031-82 was used in Flow Cytometry to study the roles of Sema4A in experimental autoimmune myocarditis.

Wed Nov 26 00:00:00 EST 2008

Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease.

Experimental hematology

Tawara I,Maeda Y,Sun Y,Lowler KP,Liu C,Toubai T,McKenzie AN,Reddy P

14-0031-82 was used in In vitro experiments to investigate the role of Th1 and Th2 polarization in acute graft-vs-host-disease, showing that combined Th2 cytokine deficiency in donor T cells aggravates disease.

Fri Aug 01 00:00:00 EDT 2008

p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.

PloS one

Cheng N,van de Wetering CI,Knudson CM

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2008

The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.

PloS one

Bauler TJ,Hendriks WJ,King PD

14-0031 was used in Flow cytometry/Cell sorting to study the role of the protein tyrosine phosphatases, PTPN3 and PTPN4, in T cell receptor signal transduction.

Thu Feb 19 00:00:00 EST 2009

Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine.

Gastroenterology

Kang SG,Piniecki RJ,Hogenesch H,Lim HW,Wiebke E,Braun SE,Matsumoto S,Kim CH

14-0031 was used in in vitro experiments to demonstrate that the CCL5-CCR5 chemokine axis is involved in preferential recruitment of FoxP3+ regulatory T-cells.

Thu Mar 01 00:00:00 EST 2007

Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice.

Blood

Chappaz S,Flueck L,Farr AG,Rolink AG,Finke D

14-0031 was used in Immunohistochemistry-immunofluorescence to investigate the role of TSLP in lymphopoiesis and immune cell development in IL-7-deficient mice.

Sat Dec 01 00:00:00 EST 2007

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.

The Journal of clinical investigation

Humblet-Baron S,Sather B,Anover S,Becker-Herman S,Kasprowicz DJ,Khim S,Nguyen T,Hudkins-Loya K,Alpers CE,Ziegler SF,Ochs H,Torgerson T,Campbell DJ,Rawlings DJ

14-0031 was used in Flow cytometry/Cell sorting to investigate whether alterations in Treg function might explain Wiskott-Aldrich syndrome pathology, showing that WASp is required for Treg homeostasis.

Thu Feb 01 00:00:00 EST 2007

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses.

The Journal of experimental medicine

Reiley WW,Jin W,Lee AJ,Wright A,Wu X,Tewalt EF,Leonard TO,Norbury CC,Fitzpatrick L,Zhang M,Sun SC

14-0031 was used in Functional assays to show that the deubiquitinating enzyme, CYLD, plays a pivotal role in regulating T cell activation and homeostasis.

Mon Jun 11 00:00:00 EDT 2007

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

Proceedings of the National Academy of Sciences of the United States of America

Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T

14-0031-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.

Tue Jan 30 00:00:00 EST 2007

The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice.

Diabetes

Pop SM,Wong CP,He Q,Wang Y,Wallet MA,Goudy KS,Tisch R

14-0031 was used in in vitro experiments to demonstrate that the frequency and maintenance of FoxP3-expressing CD4(+)CD25(+) Treg influence antigen-induced suppression of ongoing beta-cell autoimmunity in diabetic recipients.

Tue May 01 00:00:00 EDT 2007

Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors.

Oncogene

Min JN,Huang L,Zimonjic DB,Moskophidis D,Mivechi NF

14-0031 was used in Functional assays to link the loss of Hsf1-dependent function to decreased susceptibility to spontaneous lymphomagenesis.

Thu Aug 02 00:00:00 EDT 2007

Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice.

Journal of virology

Wu TC,Wang YF,Lee YP,Wang JR,Liu CC,Wang SM,Lei HY,Su IJ,Yu CK

14-0031 was used in Flow cytometry/Cell sorting to study how live vaccine is feasible for EV71 and that intertypic cross-reactivity of enteroviruses may provide a way to determine the prevalence of EV71.

Mon Oct 01 00:00:00 EDT 2007

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.

Molecular and cellular biology

Tenno M,Ohtsubo K,Hagen FK,Ditto D,Zarbock A,Schaerli P,von Andrian UH,Ley K,Le D,Tabak LA,Marth JD

14-0031 was used in Flow cytometry/Cell sorting to find that ppGalNAcT-1 plays key roles in cell and glycoprotein selective functions that modulate the haematopoietic system.

Sat Dec 01 00:00:00 EST 2007

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.

International journal of experimental pathology

DuPré SA,Redelman D,Hunter KW

Published figure using CD3e monoclonal antibody (Product # 14-0031-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2007

Orally administered bisphenol A disturbed antigen specific immunoresponses in the naïve condition.

Bioscience, biotechnology, and biochemistry

Goto M,Takano-Ishikawa Y,Ono H,Yoshida M,Yamaki K,Shinmoto H

14-0031 was used in Functional assays to investigate the effects of orally administered bisphenol A on antigen-specific responses of the naïve immune system.

Sat Sep 01 00:00:00 EDT 2007

Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.

The Journal of biological chemistry

Grigorian A,Lee SU,Tian W,Chen IJ,Gao G,Mendelsohn R,Dennis JW,Demetriou M

14-0031 was used in Functional assays to investigate how the environment influences susceptibility to autoimmunity, showing that autoimmunity can be controlled through metabolite flux to N-glycan biosynthesis.

Fri Jul 06 00:00:00 EDT 2007

N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.

The Journal of biological chemistry

Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M

14-0031 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.

Fri Nov 16 00:00:00 EST 2007

Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.

Journal of autoimmunity

Sharma R,Zheng L,Guo X,Fu SM,Ju ST,Jarjour WN

14-0031 was used in Flow cytometry/Cell sorting to investigate whether salivary and lacrimal glands are targeted in IL-2 knockout, IL-2Ralpha KO and scurfy mice.

Fri Dec 01 00:00:00 EST 2006

Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportions.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Luke PP,Deng JP,Lian D,O'Connell PJ,Garcia B,Jevnikar AM,Zhong R

14-0031-82 was used in Flow Cytometry to assess the importance of CD45RBhi T-cell depletion in murine cardiac allograft survival.

Fri Sep 01 00:00:00 EDT 2006

HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.

International journal of cancer

Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH

Thu Jun 01 00:00:00 EDT 2006

Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.

Journal of virology

Xin KQ,Mizukami H,Urabe M,Toda Y,Shinoda K,Yoshida A,Oomura K,Kojima Y,Ichino M,Klinman D,Ozawa K,Okuda K

14-0031 was used in Flow cytometry/Cell sorting to investigate the ability of different adeno-associated virus vectors expressing the human immunodeficiency virus to induce a robust immune response, and the factors which affect this.

Fri Dec 01 00:00:00 EST 2006

Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis.

The American journal of pathology

Anghelina D,Pewe L,Perlman S

14-0031 was used in an ELISpot assay to show that the host response to a single JHMV-specific immunodominant CD4 T-cell epitope is critical for severe disease.

Sat Jul 01 00:00:00 EDT 2006

Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways.

Infection and immunity

Grabig A,Paclik D,Guzy C,Dankof A,Baumgart DC,Erckenbrecht J,Raupach B,Sonnenborn U,Eckert J,Schumann RR,Wiedenmann B,Dignass AU,Sturm A

14-0031 was used in Functional assays to analyse the effects of probiotic Escherichia coli Nissle strain 1917 in experimental colitis, showing that it ameliorates experimental colitis via TLR2- and TLR4-dependent pathways.

Sat Jul 01 00:00:00 EDT 2006

An essential role for c-FLIP in the efficient development of mature T lymphocytes.

The Journal of experimental medicine

Zhang N,He YW

14-0031 was used in Western Blotting to study the role of the apoptotic regulator, cellular FLICE-like inhibitory protein (c-FLIP), during thymocyte development.

Mon Aug 01 00:00:00 EDT 2005

Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Proceedings of the National Academy of Sciences of the United States of America

Nakae S,Suto H,Kakurai M,Sedgwick JD,Tsai M,Galli SJ

14-0031 was used in Functional assays to investigate the mechanisms by which mast cells influence T cells in T cell-mediated disorders, showing that they enhance activation.

Tue May 03 00:00:00 EDT 2005

Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Krieg C,Han P,Stone R,Goularte OD,Kaye J

Tue Nov 15 00:00:00 EST 2005

CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.

Investigative ophthalmology & visual science

Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M

Sat Oct 01 00:00:00 EDT 2005

Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells.

The Journal of experimental medicine

Kieper WC,Tan JT,Bondi-Boyd B,Gapin L,Sprent J,Ceredig R,Surh CD

14-0031 was used in Flow cytometry/Cell sorting to investigate the large increases in T cell generation observed in IL-7-overexpressing transgenic mice.

Mon Jun 17 00:00:00 EDT 2002

Bioinformatics

Protein Aliases: CD247; CD247 antigen; CD3 antigen, zeta polypeptide; CD3 TCR complex; CD3-zeta/eta; CD3d; CD3e; CD3g; FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex

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Gene Aliases: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; Cd247; CD3; Cd3-eta; Cd3-zeta; Cd3d; Cd3e; CD3epsilon; Cd3g; Cd3h; Cd3z; Cd3zeta; Ctg-3; Ctg3; T3d; T3e; T3g; T3z; Tcrk; Tcrz

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UniProt ID: (Mouse) P24161, (Mouse) P04235, (Mouse) P22646, (Mouse) P11942

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Entrez Gene ID: (Mouse) 12503, (Mouse) 12500, (Mouse) 12501, (Mouse) 12502

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Function(s)

transmembrane signaling receptor activity protein binding identical protein binding protein heterodimerization activity signal transducer activity SH3 domain binding defense/immunity protein immunoglobulin receptor superfamily

Process(es)

Performance Guarantee

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CD3e Monoclonal Antibody (145-2C11), eBioscience™

CD3e Antibody (14-0031-82) in Flow

Product Details

14-0031-82

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Immunoprecipitation (IP)

Functional Assay (Functional)

Radioimmune Assays (RIA)

Blocking Assay (BLOCK)

T-Cell Activation (TCA)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

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Type

Clone

Conjugate

Form

Concentration

Purification

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RRID

Product Specific Information

Target Information

Bioinformatics

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