Invitrogen

CD3e Monoclonal Antibody (145-2C11), APC-eFluor™ 780, eBioscience™

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Antibody Testing Data (1)
Published Figures (98)

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CD3e Antibody (47-0031-82) in Flow

Staining of C57Bl/6 splenocytes with Anti-Mouse CD19 PE (Product # 12-0193-82) and 0.5 µg of Armenian Hamster IgG Isotype Control APC-eFluor® 780 (Product # 47-4888-80) (left) or 0.5 µg of Anti-Mouse CD3e APC-eFluor® 780 (right). Cells in the lymphocyte gate were used for analysis.

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Product Details

47-0031-82

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Flow Cytometry (Flow)

1 µg/test

View 112 publications 112 publications

Functional Assay (Functional)

View 1 publication 1 publication

T-Cell Activation (TCA)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Bacteria, Human, Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), APC-eFluor™ 780, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

145-2C11

Conjugate

APC-eFluor™ 780 APC-eFluor™ 780 APC-eFluor™ 780

Excitation/Emission Max

756/785 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11149861

Product Specific Information

Description: The 145-2C11 monoclonal antibody reacts with mouse CD3e, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits, gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Binding of 145-2C11 to TCR initiates the intracellular biochemical pathway resulting in cellular activation, proliferation, and apoptosis depending on specific conditions utilized. 145-2C11 is commonly used as a phenotypic marker for mouse T cells.

Applications Reported: This 145-2C11 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This 145-2C11 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

APC-eFluor 780 emits at 780 nm and is excited with the Red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.

Light sensitivity: This tandem is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 633-647 nm; Emission: 780 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy.

NPJ vaccines

Teymournejad O,Li Z,Beesetty P,Yang C,Montgomery CP

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Jan 24 00:00:00 EST 2023

IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity.

eLife

Schick J,Altunay M,Lacorcia M,Marschner N,Westermann S,Schluckebier J,Schubart C,Bodendorfer B,Christensen D,Alexander C,Wirtz S,Voehringer D,da Costa CP,Lang R

47-0031-82 was used in Flow cytometry/Cell sorting to demonstrate downregulation of MINCLE expression on monocytes and macrophages by IL-4 as a possible mechanism of thwarted Th17 vaccination responses by underlying helminth infection.

Wed Feb 08 00:00:00 EST 2023

NCR negative group 3 innate lymphoid cell (NCR^- ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.

Immunity, inflammation and disease

Chu S,Ma L,Yang X,Xiao B,Liang Y,Zheng S,Li L

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.

Diabetes

Luan D,Dadpey B,Zaid J,Bridge-Comer PE,DeLuca JH,Xia W,Castle J,Reilly SM

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

VX-765 reduces neuroinflammation after spinal cord injury in mice.

Neural regeneration research

Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ

47-0031-82 was used in Flow Cytometry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.

Wed Sep 01 00:00:00 EDT 2021

A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.

Journal of cellular and molecular medicine

Wei DP,Li DD,Gu AQ,Ji WH,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.

The European journal of neuroscience

Frühauf M,Zeitschel U,Höfling C,Ullm F,Rabiger FV,Alber G,Pompe T,Müller U,Roßner S

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.

The Journal of biological chemistry

McAndrews KM,Che SPY,LeBleu VS,Kalluri R

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Aug 20 00:00:00 EDT 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Sat Jan 30 00:00:00 EST 2021

Obesity results in adipose tissue T cell exhaustion.

JCI insight

Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Nature communications

Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Jul 14 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.

Cell

Giampazolias E,Schulz O,Lim KHJ,Rogers NC,Chakravarty P,Srinivasan N,Gordon O,Cardoso A,Buck MD,Poirier EZ,Canton J,Zelenay S,Sammicheli S,Moncaut N,Varsani-Brown S,Rosewell I,Reis e Sousa C

47-0031-82 was used in T-Cell Activation to reveal a natural barrier to cross-presentation of cancer antigens that dampens anti-tumor CD8+ T cell responses.

Thu Jul 22 00:00:00 EDT 2021

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.

iScience

Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.

Cell stem cell

Shook BA,Wasko RR,Mano O,Rutenberg-Schoenberg M,Rudolph MC,Zirak B,Rivera-Gonzalez GC,López-Giráldez F,Zarini S,Rezza A,Clark DA,Rendl M,Rosenblum MD,Gerstein MB,Horsley V

47-0031-82 was used in Flow Cytometry to identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin.

Thu Jun 04 00:00:00 EDT 2020

Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells.

Cancer immunology research

Wijewarnasuriya D,Bebernitz C,Lopez AV,Rafiq S,Brentjens RJ

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Antitumor Effect and Immune Response of Nanosecond Pulsed Electric Fields in Pancreatic Cancer.

Frontiers in oncology

Zhao J,Chen S,Zhu L,Zhang L,Liu J,Xu D,Tian G,Jiang T

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Impact of S1P Mimetics on Mesenteric Ischemia/Reperfusion Injury.

Pharmaceuticals (Basel, Switzerland)

Potì F,Giorgio C,Zini I,Nofer JR,Vivo V,Palese S,Ballabeni V,Barocelli E,Bertoni S

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Oct 09 00:00:00 EDT 2020

CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.

FEBS open bio

Liu Y,Gao Y,Hao H,Hou T

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

IDO1⁺ Paneth cells promote immune escape of colorectal cancer.

Communications biology

Pflügler S,Svinka J,Scharf I,Crncec I,Filipits M,Charoentong P,Tschurtschenthaler M,Kenner L,Awad M,Stift J,Schernthanner M,Bischl R,Herndler-Brandstetter D,Glitzner E,Moll HP,Casanova E,Timelthaler G,Sibilia M,Gnant M,Lax S,Thaler J,Müller M,Strobl B,Mohr T,Kaser A,Trajanoski Z,Heller G,Eferl R

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.

Cell reports

Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Jun 17 00:00:00 EDT 2021

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.

Oncoimmunology

Cervera-Carrascon V,Quixabeira DCA,Santos JM,Havunen R,Zafar S,Hemminki O,Heiniö C,Munaro E,Siurala M,Sorsa S,Mirtti T,Järvinen P,Mildh M,Nisen H,Rannikko A,Anttila M,Kanerva A,Hemminki A

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.

Nature communications

Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G

47-0031 was used in Flow cytometry/Cell sorting to study the mechanism that controls the development of αβ T cell lineages in the thymus.

Mon May 04 00:00:00 EDT 2020

CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.

Journal of neuroinflammation

Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ

47-0031 was used in Flow cytometry/Cell sorting to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.

Sat Aug 29 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

47-0031 was used in flow cytometry to analyse the myeloid populations in various mouse tissues by flow cytometry.

Fri Jun 19 00:00:00 EDT 2020

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

47-0031 was used in flow cytometry to analyse the myeloid populations in various mouse tissues by flow cytometry.

Fri Jun 19 00:00:00 EDT 2020

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.

Frontiers in immunology

Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA

47-0031 was used in Flow cytometry/Cell sorting to suggest that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.

Mon Jun 14 00:00:00 EDT 2021

Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.

eLife

Piersma SJ,Poursine-Laurent J,Yang L,Barber GN,Parikh BA,Yokoyama WM

47-0031 was used in Flow cytometry/Cell sorting to contrast anti-viral effects of MyD88 versus STING in distinct cell types that are infected with murine CMV (MCMV).

Wed Jul 29 00:00:00 EDT 2020

Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny.

Cell reports

Simic M,Manosalva I,Spinelli L,Gentek R,Shayan RR,Siret C,Girard-Madoux M,Wang S,de Fabritus L,Verschoor J,Kerdiles YM,Bajenoff M,Stumm R,Golub R,van de Pavert SA

47-0031 was used in Flow cytometry/Cell sorting to identify a major contribution from embryonic hemogenic endothelium, but not the yolk sac, toward LTi progenitors.

Tue Aug 11 00:00:00 EDT 2020

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.

Cancer cell

Srivastava S,Salter AI,Liggitt D,Yechan-Gunja S,Sarvothama M,Cooper K,Smythe KS,Dudakov JA,Pierce RH,Rader C,Riddell SR

47-0031 was used in Flow cytometry/Cell sorting to demonstrate the use of “AND” logic gates as a strategy to increase the portfolio of cell surface molecules on solid tumors that can be targeted safely with CAR-T cells.

Mon Mar 18 00:00:00 EDT 2019

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Cell host & microbe

Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Dec 11 00:00:00 EST 2019

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Cell host & microbe

Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Dec 11 00:00:00 EST 2019

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.

Cell stem cell

Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK

47-0031 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.

Thu Apr 04 00:00:00 EDT 2019

1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension.

British journal of pharmacology

Mikolajczyk TP,Nosalski R,Skiba DS,Koziol J,Mazur M,Justo-Junior AS,Kowalczyk P,Kusmierczyk Z,Schramm-Luc A,Luc K,Maffia P,Graham D,Kiss AK,Naruszewicz M,Guzik TJ

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

CD160 serves as a negative regulator of NKT cells in acute hepatic injury.

Nature communications

Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Jul 22 00:00:00 EDT 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.

Nature communications

Kang YH,Biswas A,Field M,Snapper SB

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

Increased Incidence of Colon Tumors in AOM-Treated Apc ^1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine.

Frontiers in oncology

Metzger R,Maruskova M,Krebs S,Janssen KP,Krug AB

47-0031-82 was used in Flow cytometry/Cell sorting to develop a model with higher resemblance to human CRC and to characterize tumor infiltrating immune cells in spontaneously developing colon tumors compared to small intestinal tumors.

Thu Oct 01 00:00:00 EDT 2020

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.

Nature medicine

Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS

47-0031 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.

Fri Jun 01 00:00:00 EDT 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh.

Development (Cambridge, England)

Solanki A,Yanez DC,Ross S,Lau CI,Papaioannou E,Li J,Saldaña JI,Crompton T

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Jan 31 00:00:00 EST 2018

The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice.

European journal of immunology

Zimmermann J,Durek P,Kühl AA,Schattenberg F,Maschmeyer P,Siracusa F,Lehmann K,Westendorf K,Weber M,Riedel R,Müller S,Radbruch A,Chang HD

47-0031 was used in Flow cytometry/Cell sorting to study the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.

Mon Jan 01 00:00:00 EST 2018

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Journal of neuroimmunology

Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response.

Scientific reports

Rodríguez-Baena FJ,Redondo-García S,Peris-Torres C,Martino-Echarri E,Fernández-Rodríguez R,Plaza-Calonge MDC,Anderson P,Rodríguez-Manzaneque JC

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Aug 30 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

47-0031 was used in Flow cytometry/Cell sorting to assess the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase 1 axis as a druggable mitochondrial target for promoting immunometabolic and organ homeostasis during sepsis.

Thu Aug 09 00:00:00 EDT 2018

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.

Nature communications

Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF

47-0031 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.

Mon Jul 16 00:00:00 EDT 2018

Integrin CD11b activation drives anti-tumor innate immunity.

Nature communications

Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA

47-0031 was used in Flow cytometry/Cell sorting to identify CD11b as a negative regulator of immune suppression and a target for cancer immune therapy.

Wed Dec 19 00:00:00 EST 2018

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Cell

Kortlever RM,Sodir NM,Wilson CH,Burkhart DL,Pellegrinet L,Brown Swigart L,Littlewood TD,Evan GI

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Nov 30 00:00:00 EST 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.

Cell stem cell

Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ

47-0031 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.

Thu Jun 01 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

PTEN drives Th17 cell differentiation by preventing IL-2 production.

The Journal of experimental medicine

Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Nov 06 00:00:00 EST 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.

Journal of cellular and molecular medicine

Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Jan 06 00:00:00 EST 2017

The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.

Nature microbiology

Grau KR,Roth AN,Zhu S,Hernandez A,Colliou N,DiVita BB,Philip DT,Riffe C,Giasson B,Wallet SM,Mohamadzadeh M,Karst SM

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.

JCI insight

Lam JH,Chua YL,Lee PX,Martínez Gómez JM,Ooi EE,Alonso S

47-0031 was used in Flow cytometry/Cell sorting to establish the development of dengue vaccine candidates that induce protective CD8+ T cells despite the presence of enhancing, interfering maternal antibodies.

Thu Dec 21 00:00:00 EST 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.

Autophagy

Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Diacylglycerol Kinase ζ Is a Target To Enhance NK Cell Function.

Journal of immunology (Baltimore, Md. : 1950)

Yang E,Singh BK,Paustian AM,Kambayashi T

47-0031 was used in Flow cytometry/Cell sorting to investigate methods to enhance NK cell function, showing that diacylglycerol kinase ζ is a target for enhancement of NK function.

Mon Aug 01 00:00:00 EDT 2016

Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice.

Infection and immunity

Ruan S,Samuelson DR,Assouline B,Morre M,Shellito JE

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia.

Oncoimmunology

Finkel P,Frey B,Mayer F,Bösl K,Werthmöller N,Mackensen A,Gaipl US,Ullrich E

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.

Nature communications

Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Jul 15 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.

Nature communications

Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Oct 21 00:00:00 EDT 2016

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Cell reports

Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8⁺ T-cell responses and immune memory.

Oncoimmunology

Wu J,Waxman DJ

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.

PloS one

Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue May 24 00:00:00 EDT 2016

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.

BMC cancer

Gillgrass AE,Chew MV,Krneta T,Ashkar AA

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2015

hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells.

PloS one

Siegemund S,Shepherd J,Xiao C,Sauer K

47-0031 was used in Flow cytometry/Cell sorting to assess the deletion of floxed genes during lymphocyte development, as mediated by the transgenes hCD2-iCre and Vav-iCre.

Tue Apr 05 00:00:00 EDT 2016

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.

Science translational medicine

Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion.

European journal of immunology

Larsen J,Dall M,Antvorskov JC,Weile C,Engkilde K,Josefsen K,Buschard K

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Role of IL-17 and TGF-β in peritoneal adhesion formation after surgical trauma.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Wang G,Wu K,Li W,Zhao E,Shi L,Wang J,Shuai X,Cai K,Lu X,Tao K,Wang G

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2015

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.

PloS one

Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2015

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis.

Clinical and experimental immunology

Wang J,Shan Y,Jiang Z,Feng J,Li C,Ma L,Jiang Y

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice.

Journal of cancer science & therapy

Zheng D,Chen H,Bartee MY,Williams J,Davids JA,Lomas DA,McFadden G,Lucas AR

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Aug 19 00:00:00 EDT 2013

Pulmonary T cell activation in response to chronic particulate air pollution.

American journal of physiology. Lung cellular and molecular physiology

Deiuliis JA,Kampfrath T,Zhong J,Oghumu S,Maiseyeu A,Chen LC,Sun Q,Satoskar AR,Rajagopalan S

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Feb 15 00:00:00 EST 2012

Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

American journal of physiology. Gastrointestinal and liver physiology

Ernst PB,Erickson LD,Loo WM,Scott KG,Wiznerowicz EB,Brown CC,Torres-Velez FJ,Alam MS,Black SG,McDuffie M,Feldman SH,Wallace JL,McKnight GW,Padol IT,Hunt RH,Tung KS

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

Species-specific activity of glycolipid ligands for invariant NKT cells.

Chembiochem : a European journal of chemical biology

Dangerfield EM,Cheng JM,Knight DA,Weinkove R,Dunbar PR,Hermans IF,Timmer MS,Stocker BL

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Jun 18 00:00:00 EDT 2012

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.

The Journal of biological chemistry

Badeaux AI,Yang Y,Cardenas K,Vemulapalli V,Chen K,Kusewitt D,Richie E,Li W,Bedford MT

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Jan 02 00:00:00 EST 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.

Biology of reproduction

Meng J,Greenlee AR,Taub CJ,Braun RE

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2011

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.

Obesity (Silver Spring, Md.)

Strissel KJ,DeFuria J,Shaul ME,Bennett G,Greenberg AS,Obin MS

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2010

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Gastroenterology

Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2009

Tracking epitope-specific T cells.

Nature protocols

Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2009

p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.

PloS one

Cheng N,van de Wetering CI,Knudson CM

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2008

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.

International journal of experimental pathology

DuPré SA,Redelman D,Hunter KW

Published figure using CD3e monoclonal antibody (Product # 47-0031-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2007

HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.

International journal of cancer

Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH

Thu Jun 01 00:00:00 EDT 2006

Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Krieg C,Han P,Stone R,Goularte OD,Kaye J

Tue Nov 15 00:00:00 EST 2005

CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.

Investigative ophthalmology & visual science

Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M

Sat Oct 01 00:00:00 EDT 2005

Bioinformatics

Protein Aliases: CD247; CD247 antigen; CD3 antigen, zeta polypeptide; CD3 TCR complex; CD3-zeta/eta; CD3d; CD3e; CD3g; FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex

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Gene Aliases: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; Cd247; CD3; Cd3-eta; Cd3-zeta; Cd3d; Cd3e; CD3epsilon; Cd3g; Cd3h; Cd3z; Cd3zeta; Ctg-3; Ctg3; T3d; T3e; T3g; T3z; Tcrk; Tcrz

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UniProt ID: (Mouse) P24161, (Mouse) P04235, (Mouse) P22646, (Mouse) P11942

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Entrez Gene ID: (Mouse) 12503, (Mouse) 12500, (Mouse) 12501, (Mouse) 12502

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Function(s)

transmembrane signaling receptor activity protein binding identical protein binding protein heterodimerization activity signal transducer activity SH3 domain binding defense/immunity protein immunoglobulin receptor superfamily

Process(es)

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CD3e Monoclonal Antibody (145-2C11), APC-eFluor™ 780, eBioscience™

CD3e Antibody (47-0031-82) in Flow

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47-0031-82

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Functional Assay (Functional)

T-Cell Activation (TCA)

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