Product References
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
25-0031-82 was used in Flow Cytometry to demonstrate that TRAF6 deletion or MALT1 paracaspase inactivation are highly interdependent in causing the distinct immune pathologies.
Mon Feb 13 00:00:00 EST 2023
IFNγ Transcribed by IRF1 in CD4+ Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis.
Aging and disease
Chen H,Wang Q,Li J,Li Y,Chen A,Zhou J,Zhao J,Mao Z,Zhou Z,Zhang J,Wang Y,Wang R,Li Q,Zhang Y,Jiang R,Miao D,Jin J
25-0031-82 was used in Flow Cytometry to find that physiological aging increased pulmonary CD4+ TEM cells, IFNγ was produced mainly by CD4+ TEM cells, and pulmonary cells had increased responsiveness to IFNγ signaling.
Fri Dec 01 00:00:00 EST 2023
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts.
The Journal of experimental medicine
Kerdidani D,Aerakis E,Verrou KM,Angelidis I,Douka K,Maniou MA,Stamoulis P,Goudevenou K,Prados A,Tzaferis C,Ntafis V,Vamvakaris I,Kaniaris E,Vachlas K,Sepsas E,Koutsopoulos A,Potaris K,Tsoumakidou M
25-0031-82 was used in Flow cytometry/Cell sorting to characterize in the lungs a subset of antigen-presenting fibroblasts with tumor-suppressive properties and propose that cancer immunotherapies might be strongly dependent on in situ MHCII antigen presentation.
Mon Feb 07 00:00:00 EST 2022
A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2.
Cell reports
Yuan Y,Zhang X,Chen R,Li Y,Wu B,Li R,Zou F,Ma X,Wang X,Chen Q,Deng J,Zhang Y,Chen T,Lin Y,Yan S,Zhang X,Li C,Bu X,Peng Y,Ke C,Deng K,Pan T,He X,Zhang Y,Zhang H
25-0031-82 was used in Flow Cytometry to develop a bivalent nanoparticle vaccine that displays the receptor binding domains of the D614G and B.1.351 strains of SARS-CoV-2.
Tue Jan 18 00:00:00 EST 2022
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
25-0031-82 was used in Flow cytometry/Cell sorting to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation.
Scientific reports
Yoshida K,Satoh Y,Uchimura A,Misumi M,Kyoizumi S,Taga M,Matsuda Y,Noda A,Kusunoki Y
25-0031-82 was used in Flow cytometry/Cell sorting to reveal development of massive CH; with increases in peripheral blood myeloid cells, red blood cell distribution width and recurrent somatic mutations, due to radiation exposure.
Fri Oct 14 00:00:00 EDT 2022
Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.
iScience
Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS
25-0031-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.
Fri Jun 17 00:00:00 EDT 2022
Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors.
Journal for immunotherapy of cancer
Potluri HK,Ferreira CA,Grudzinski J,Massey C,Aluicio-Sarduy E,Engle JW,Kwon O,Marsh IR,Bednarz BP,Hernandez R,Weichert JP,McNeel DG
25-0031-82 was used in Flow cytometry/Cell sorting to suggest that the combination of 90Y-NM600 TRT and PD-1 blockade therapy is ineffective in these prostate cancer models due to the activating effect of anti-PD-1 on Tregs.
Mon Aug 01 00:00:00 EDT 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
25-0031-82 was used in Flow cytometry/Cell sorting to provide mechanistic insights on FGF-2 signaling in the modulation of VEGF pathway activation in the NPC microenvironment and propose an effective NPC-targeted therapy by using a clinically available drug.
Fri Aug 19 00:00:00 EDT 2022
P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.
Frontiers in immunology
Schall N,Talamini L,Wilhelm M,Jouvin-Marche E,Muller S
25-0031-82 was used in Flow cytometry/Cell sorting to suggest that P140 belongs to a new family of non-immunosuppressive immunoregulators that do not correct T and B cell abnormalities but rather contribute to the clearance of deleterious T and B cells.
Tue Jun 21 00:00:00 EDT 2022
Enhancing and inhibitory motifs regulate CD4 activity.
eLife
Lee MS,Tuohy PJ,Kim CY,Lichauco K,Parrish HL,Van Doorslaer K,Kuhns MS
25-0031-82 was used in Flow cytometry/Cell sorting to indicate that CD4-Lck interactions derive their importance from the counterbalancing activity of the inhibitory motif, as well as motifs that direct CD4-Lck pairs to specific membrane compartments.
Thu Jul 21 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
25-0031-82 was used in Flow cytometry/Cell sorting to suggest that a hematopoietic-mesenchymal signal exists, and that the state of the HSCs is important for the stability of MSC properties.
Tue Jul 26 00:00:00 EDT 2022
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Immunity
Lin X,Gaudino SJ,Jang KK,Bahadur T,Singh A,Banerjee A,Beaupre M,Chu T,Wong HT,Kim CK,Kempen C,Axelrad J,Huang H,Khalid S,Shah V,Eskiocak O,Parks OB,Berisha A,McAleer JP,Good M,Hoshino M,Blumberg R,Bialkowska AB,Gaffen SL,Kolls JK,Yang VW,Beyaz S,Cadwell K,Kumar P
25-0031-82 was used in Flow cytometry/Cell sorting to suggest that the cross talk between immune cells and stem cells regulates secretory cell lineage commitment and the integrity of the mucosa.
Tue Feb 08 00:00:00 EST 2022
A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.
Nature communications
Wu J,Yang K,Cai S,Zhang X,Hu L,Lin F,Wu SQ,Xiao C,Liu WH,Han J
25-0031-82 was used in Flow cytometry/Cell sorting to show that plasma cell differentiation and antibody responses are severely impaired in mice with B-cell-specific deletion of p38α, while B-cell development and the germinal centre B-cell response are spared.
Mon Nov 28 00:00:00 EST 2022
Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice.
Frontiers in immunology
Patil ND,Domingues O,Masquelier C,Theresine M,Schlienger O,Njinju Amin Asaba C,Thomas M,Seguin-Devaux C,Slevogt H,Ollert M,Zimmer J
25-0031-82 was used in Flow cytometry/Cell sorting to show that we completed our investigations with phenotypic studies of NK cells from these mice.
Tue Aug 02 00:00:00 EDT 2022
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.
The Journal of clinical investigation
Yu W,Zhong L,Yao L,Wei Y,Gui T,Li Z,Kim H,Holdreith N,Jiang X,Tong W,Dyment N,Liu XS,Yang S,Choi Y,Ahn J,Qin L
25-0031 was used in Flow cytometry/Cell sorting to identify MALPs as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
Tue Jan 19 00:00:00 EST 2021
Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.
The Journal of biological chemistry
McAndrews KM,Che SPY,LeBleu VS,Kalluri R
25-0031-82 was used in Flow cytometry/Cell sorting to highlight the potential of exosomes in general, and iExoSTINGa specifically, in enhancing cancer therapy outcomes.
Fri Aug 20 00:00:00 EDT 2021
TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.
Cell reports
Willemsen J,Neuhoff MT,Hoyler T,Noir E,Tessier C,Sarret S,Thorsen TN,Littlewood-Evans A,Zhang J,Hasan M,Rush JS,Guerini D,Siegel RM
25-0031-82 was used in Flow Cytometry to elucidate a molecular mechanism linking TNF to type-I interferon signaling and suggest a potential benefit for therapeutic targeting of cGAS/STING in TNF-driven diseases.
Tue Nov 09 00:00:00 EST 2021
Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
Cell reports
Nanou A,Bourbouli M,Vetrano S,Schaeper U,Ley S,Kollias G
25-0031-82 was used in Flow Cytometry to investigate in vivo the role of Tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase (MAP3K) member with pleiotropic effects in inflammation and cancer.
Tue May 25 00:00:00 EDT 2021
Expanded renal lymphatics improve recovery following kidney injury.
Physiological reports
Baranwal G,Creed HA,Black LM,Auger A,Quach AM,Vegiraju R,Eckenrode HE,Agarwal A,Rutkowski JM
25-0031-82 was used in Flow cytometry/Cell sorting to demonstrate that increased lymphatic density prior to injury alters the injury recovery response and affords protection from CKD progression.
Mon Nov 01 00:00:00 EDT 2021
Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.
ACS nano
Ling X,Jiang X,Li Y,Han W,Rodriguez M,Xu Z,Lin W
25-0031-82 was used in flow cytometry to sequential delivery of antiangiogenic and chemotherapeutic agents with bioresponsive NPs activates tumor microenvironments and synergizes with CD40 agonist to regress transplanted tumors and inhibit disseminated tumors in a lung cancer mouse model.
Tue Jan 26 00:00:00 EST 2021
Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo.
Cell reports
Chen ELY,Lee CR,Thompson PK,Wiest DL,Anderson MK,Zúñiga-Pflücker JC
25-0031-82 was used in Flow Cytometry to employ RBPJ-inducible and KN6-transgenic mice to assess the roles of ontogenic timing, T cell receptor (TCR) signal strength, and Notch signaling.
Tue Jun 08 00:00:00 EDT 2021
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.
Nature communications
Dunker C,Polke M,Schulze-Richter B,Schubert K,Rudolphi S,Gressler AE,Pawlik T,Prada Salcedo JP,Niemiec MJ,Slesiona-Künzel S,Swidergall M,Martin R,Dandekar T,Jacobsen ID
25-0031-82 was used in Flow Cytometry to challenge the long-standing hypothesis that hyphae are essential for pathogenesis of systemic candidiasis by C. albicans.
Wed Jun 23 00:00:00 EDT 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
25-0031 was used in Flow cytometry/Cell sorting to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 EDT 2020
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Immunity
Śledzińska A,Vila de Mucha M,Bergerhoff K,Hotblack A,Demane DF,Ghorani E,Akarca AU,Marzolini MAV,Solomon I,Vargas FA,Pule M,Ono M,Seddon B,Kassiotis G,Ariyan CE,Korn T,Marafioti T,Lord GM,Stauss H,Jenner RG,Peggs KS,Quezada SA
25-0031 was used in Flow cytometry/Cell sorting to underscore the role of Treg cells, IL-2, and Blimp-1 in controlling the differentiation of cytotoxic CD4+ T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation.
Tue Jan 14 00:00:00 EST 2020
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.
Nature immunology
Schuijs MJ,Png S,Richard AC,Tsyben A,Hamm G,Stockis J,Garcia C,Pinaud S,Nicholls A,Ros XR,Su J,Eldridge MD,Riedel A,Serrao EM,Rodewald HR,Mack M,Shields JD,Cohen ES,McKenzie ANJ,Goodwin RJA,Brindle KM,Marioni JC,Halim TYF
25-0031 was used in Flow cytometry/Cell sorting to reveal an important function of IL-33 and ILC2s in promoting tumor metastasis via their capacity to suppress innate type 1 immunity.
Tue Sep 01 00:00:00 EDT 2020
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.
Cell death and differentiation
Nguyen PM,Dagley LF,Preaudet A,Lam N,Giam M,Fung KY,Aizel K,van Duijneveldt G,Tan CW,Hirokawa Y,Yip HYK,Love CG,Poh AR,Cruz A,Burstroem C,Feltham R,Abdirahman SM,Meiselbach K,Low RRJ,Palmieri M,Ernst M,Webb AI,Burgess T,Sieber OM,Bouillet P,Putoczki TL
25-0031-82 was used in Flow Cytometry to study a role for Bcl-G in colon cancer.
Sat Feb 01 00:00:00 EST 2020
Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis.
Science signaling
Lovisa S,Fletcher-Sananikone E,Sugimoto H,Hensel J,Lahiri S,Hertig A,Taduri G,Lawson E,Dewar R,Revuelta I,Kato N,Wu CJ,Bassett RL,Putluri N,Zeisberg M,Zeisberg EM,LeBleu VS,Kalluri R
25-0031 was used in Flow cytometry/Cell sorting to demonstrate a functional role for EndMT in the response to kidney capillary endothelial injury and highlight the contribution of endothelial-epithelial cross-talk in the development of kidney fibrosis with a potential for therapeutic intervention.
Tue Jun 09 00:00:00 EDT 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
25-0031 was used in Flow cytometry/Cell sorting to provide a framework for effective vaccination against cancer-associated herpesviruses through the elimination of latency and key immune evasion mechanisms from the pathogen.
Thu Nov 05 00:00:00 EST 2020
CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization.
Cell reports
Kinder JM,Turner LH,Stelzer IA,Miller-Handley H,Burg A,Shao TY,Pham G,Way SS
25-0031-82 was used in Immunocytochemistry to demonstrate distinct mechanisms whereby fetal tolerance is maintained during primary compared with subsequent pregnancies.
Tue Jun 23 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
25-0031 was used in Flow cytometry/Cell sorting to demonstrate that 99mTc-MY1523 SPECT/CT allowed a real-time, quantitative and dynamic mapping of PD-L1 expression in vivo, and the imaging-guided PD-L1 blockade immunotherapy significantly enhanced the therapeutic efficacy.
Sun Nov 01 00:00:00 EDT 2020
Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses.
Cell reports
Nadafi R,Gago de Graça C,Keuning ED,Koning JJ,de Kivit S,Konijn T,Henri S,Borst J,Reijmers RM,van Baarsen LGM,Mebius RE
25-0031-82 was used in Flow Cytometry to uncover the ability of LNSCs to suppress the early activation of autoreactive immune cells and maintain peripheral tolerance.
Tue Mar 24 00:00:00 EDT 2020
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nature communications
Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF
25-0031 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.
Fri Nov 13 00:00:00 EST 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
25-0031 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.
eLife
Zhong L,Yao L,Tower RJ,Wei Y,Miao Z,Park J,Shrestha R,Wang L,Yu W,Holdreith N,Huang X,Zhang Y,Tong W,Gong Y,Ahn J,Susztak K,Dyment N,Li M,Long F,Chen C,Seale P,Qin L
25-0031 was used in Flow cytometry/Cell sorting to computationally define mesenchymal progenitors at different stages and delineate their bi-lineage differentiation paths in young, adult and aging mice.
Tue Apr 14 00:00:00 EDT 2020
Relevance of PSGL-1 Expression in B Cell Development and Activation.
Frontiers in immunology
González-Tajuelo R,González-Sánchez E,Silván J,Muñoz-Callejas A,Vicente-Rabaneda E,García-Pérez J,Castañeda S,Urzainqui A
25-0031 was used in Flow cytometry/Cell sorting to conclude that although the expression of PSGL-1 in mature B cells is low, the lack of PSGL-1 compromises normal B cell development and it may also play a role in the maturation and activation of peripheral naïve B cells.
Fri Jul 16 00:00:00 EDT 2021
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
25-0031-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
CD8+ T cells induce cachexia during chronic viral infection.
Nature immunology
Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A
25-0031-82 was used in Flow Cytometry to identify the role for CD8+ T cells in infection-associated cachexia.
Sat Jun 01 00:00:00 EDT 2019
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
25-0031-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels.
Acta biomaterialia
Amer LD,Saleh LS,Walker C,Thomas S,Janssen WJ,Alper S,Bryant SJ
25-0031 was used in Flow cytometry/Cell sorting to demonstrate that MyD88-mediated inflammation is responsible in part for the formation of the fibrous capsule of the FBR.
Sun Dec 01 00:00:00 EST 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
25-0031-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.
NPJ vaccines
Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T
25-0031-82 was used in Flow cytometry/Cell sorting to suggest that the ZIKV NS4B-C100S mutant may serve as a candidate ZIKV LAV due to its attenuated phenotype and high immunogenicity.
Thu Oct 01 00:00:00 EDT 2020
Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells.
Autophagy
Oh DS,Lee HK
25-0031-82 was used in Flow Cytometry to demonstrate that Atg5 is required for proper antigen phagocytosis and presentation to MHC class II via modulation of CD36 in dendritic cells and may be a future therapeutic target for anti-tumor therapy.
Sun Dec 01 00:00:00 EST 2019
The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria.
Frontiers in immunology
Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K
25-0031 was used in Flow cytometry/Cell sorting to reveal the essential role of early host interactions in the liver that may dampen the subsequent pro-inflammatory immune responses and influence the occurrence of ECM, highlighting a novel checkpoint in this fatal pathology.
Mon Nov 16 00:00:00 EST 2020
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.
eLife
Lee S,Jo S,Talbot S,Zhang HB,Kotoda M,Andrews NA,Puopolo M,Liu PW,Jacquemont T,Pascal M,Heckman LM,Jain A,Lee J,Woolf CJ,Bean BP
25-0031-82 was used in Flow Cytometry to show that some cationic molecules applied extracellularly can powerfully inhibit both sodium channels and calcium channels, thereby blocking both nociceptor excitability and pro-inflammatory peptide release.
Mon Nov 25 00:00:00 EST 2019
The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.
Frontiers in pharmacology
Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK
25-0031 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.
Wed Sep 30 00:00:00 EDT 2020
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Cancer cell
Arce Vargas F,Furness AJS,Litchfield K,Joshi K,Rosenthal R,Ghorani E,Solomon I,Lesko MH,Ruef N,Roddie C,Henry JY,Spain L,Ben Aissa A,Georgiou A,Wong YNS,Smith M,Strauss D,Hayes A,Nicol D,O'Brien T,Mårtensson L,Ljungars A,Teige I,Frendéus B,Pule M,Marafioti T,Gore M,Larkin J,Turajlic S,Swanton C,Peggs KS,Quezada SA
25-0031 was used in Flow cytometry/Cell sorting to examine the importance of Fc-gamma receptor binding in contributing to the activity of anti-CTLA4 antibodies.
Mon Apr 09 00:00:00 EDT 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
25-0031 was used in Flow cytometry/Cell sorting to use human tumour histocultures and syngeneic tumour models treated with Newcastle disease virus to identify immune targets upregulated by OV treatment.
Mon Apr 02 00:00:00 EDT 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
25-0031 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.
Journal of autoimmunity
Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K
25-0031 was used in Flow cytometry/Cell sorting to demonstrate a fundamental role for 11 beta-hydroxysteroid dehydrogenase type 1 in the suppression of synovitis, joint destruction, and systemic bone loss.
Wed Aug 01 00:00:00 EDT 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
25-0031 was used in Flow cytometry/Cell sorting to study the effects of pre-existing anti-viral immunity on therapeutic efficacy in syngeneic mouse tumour models.
Wed Apr 04 00:00:00 EDT 2018
Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection.
Frontiers in immunology
Prendergast KA,Daniels NJ,Petersen TR,Hermans IF,Kirman JR
25-0031 was used in Flow cytometry/Cell sorting to investigate the impact of depleting langerin+ CD8α+ dendritic cells in a murine model of intravenous infection with Mycobacterium bovis bacille Calmette-Guerin.
Mon Jul 01 00:00:00 EDT 2019
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
The American journal of pathology
Prystaz K,Kaiser K,Kovtun A,Haffner-Luntzer M,Fischer V,Rapp AE,Liedert A,Strauss G,Waetzig GH,Rose-John S,Ignatius A
25-0031 was used in Flow cytometry/Cell sorting to study the mechanisms by which IL-6 regulates bone healing.
Thu Feb 01 00:00:00 EST 2018
Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.
Endocrinology
van der Spek AH,Surovtseva OV,Jim KK,van Oudenaren A,Brouwer MC,Vandenbroucke-Grauls CMJE,Leenen PJM,van de Beek D,Hernandez A,Fliers E,Boelen A
25-0031 was used in Flow cytometry/Cell sorting to study the role of optimal intracellular concentrations of the active thyroid hormone triiodothyronine in proinflammatory macrophage function.
Tue May 01 00:00:00 EDT 2018
The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species.
Endocrinology
van der Spek AH,Jim KK,Karaczyn A,van Beeren HC,Ackermans MT,Darras VM,Vandenbroucke-Grauls CMJE,Hernandez A,Brouwer MC,Fliers E,van de Beek D,Boelen A
25-0031 was used in Flow cytometry/Cell sorting to study whether type 3 deiodinase plays a role in neutrophil function during infection.
Thu Feb 01 00:00:00 EST 2018
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.
Naunyn-Schmiedeberg's archives of pharmacology
Kaiser K,Prystaz K,Vikman A,Haffner-Luntzer M,Bergdolt S,Strauss G,Waetzig GH,Rose-John S,Ignatius A
25-0031 was used in Flow cytometry/Cell sorting to suggest that selective IL-6 trans-signaling inhibition may have therapeutic potential to treat fracture healing complications in patients with concomitant injuries.
Tue May 01 00:00:00 EDT 2018
Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
Scientific reports
Beesetty P,Wieczerzak KB,Gibson JN,Kaitsuka T,Luu CT,Matsushita M,Kozak JA
25-0031 was used in Flow cytometry/Cell sorting to study the role of TRPM7 channel kinase as a novel modulator of blastogenesis, proliferation and store-operated calcium entry.
Wed Feb 14 00:00:00 EST 2018
YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells.
iScience
Balkhi MY,Wittmann G,Xiong F,Junghans RP
25-0031-82 was used in T-Cell Activation to elucidate a Yin Yang-1-centred mechanism for diverse cellular components correlated with exhaustion.
Fri Apr 27 00:00:00 EDT 2018
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates.
mBio
Schager AE,Dominguez-Medina CC,Necchi F,Micoli F,Goh YS,Goodall M,Flores-Langarica A,Bobat S,Cook CNL,Arcuri M,Marini A,King LDW,Morris FC,Anderson G,Toellner KM,Henderson IR,López-Macías C,MacLennan CA,Cunningham AF
25-0031 was used in Flow cytometry/Cell sorting to study how antibody responses to bacterial antigens develop and how vaccines like generalised modules for membrane antigens can work and help prevent infection.
Tue Mar 06 00:00:00 EST 2018
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Nature communications
Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G
25-0031 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.
Wed Apr 18 00:00:00 EDT 2018
AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.
Circulation research
Abdel Malik R,Zippel N,Frömel T,Heidler J,Zukunft S,Walzog B,Ansari N,Pampaloni F,Wingert S,Rieger MA,Wittig I,Fisslthaler B,Fleming I
25-0031 was used in Flow cytometry/Cell sorting to elucidate the role of the AMPKa2 catalytic subunit in vascular repair following ischemia.
Fri Jan 06 00:00:00 EST 2017
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.
Frontiers in immunology
Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL
25-0031 was used in Flow cytometry/Cell sorting to provide "proof-of-concept" for the development of a cryptococcal vaccine that provides cross-protection against multiple disparate serotypes of Cryptococcus.
Wed Nov 20 00:00:00 EST 2019
Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.
Oxidative medicine and cellular longevity
Ramadori P,Drescher H,Erschfeld S,Fragoulis A,Kensler TW,Wruck CJ,Cubero FJ,Trautwein C,Streetz KL,Kroy DC
25-0031 was used in Flow cytometry/Cell sorting to elucidate the effect of Nrf2 overactivation on cellular events in c-met deficient hepatocytes.
Wed Jan 31 00:00:00 EST 2018
Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis.
Frontiers in neurology
Peake K,Manning J,Lewis CA,Tran K,Rossi F,Krieger C
25-0031 was used in Flow cytometry/Cell sorting to indicate that establishment of high levels of blood and BM chimerism alone is not sufficient to induce BMDC accumulation within the CNS.
Thu Oct 01 00:00:00 EDT 2020
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
25-0031 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PloS one
Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M
25-0031 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.
Tue Sep 26 00:00:00 EDT 2017
Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.
Frontiers in cellular and infection microbiology
Wang C,Liu P,Luo J,Ding H,Gao Y,Sun L,Luo F,Liu X,He H
25-0031 was used in Flow cytometry/Cell sorting to show geldanamycin plays an important role in attenuating virus infection-induced acute lung injury/acute respiratory distress syndrome by reducing the host's inflammatory responses.
Mon Feb 26 00:00:00 EST 2018
Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes.
Cell research
Liu Q,Yang R,Huang X,Zhang H,He L,Zhang L,Tian X,Nie Y,Hu S,Yan Y,Zhang L,Qiao Z,Wang QD,Lui KO,Zhou B
25-0031 was used in Flow cytometry/Cell sorting to investigate the ability of CSCs to stimulate cardiac regeneration and repair.
Fri Jan 01 00:00:00 EST 2016
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
25-0031 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 EDT 2016
Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo.
Oncology reports
Gabrysiak M,Wachowska M,Barankiewicz J,Pilch Z,Ratajska A,Skrzypek E,Winiarska M,Domagala A,Rygiel TP,Jozkowicz A,Boon L,Golab J,Firczuk M
25-0031 was used in Flow cytometry/Cell sorting to identify factors allowing for the most immunogenic response to photodynamic therapy.
Wed Jun 01 00:00:00 EDT 2016
Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.
Infection and immunity
Chenery AL,Antignano F,Burrows K,Scheer S,Perona-Wright G,Zaph C
25-0031 was used in Flow cytometry/Cell sorting to study crosstalk between the intestine and lung during disease, showing that low-dose intestinal Trichuris muris infection alters the lung immune microenvironment.
Mon Feb 01 00:00:00 EST 2016
Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.
PloS one
Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B
25-0031 was used in Flow cytometry/Cell sorting to investigate the potential of a previously uncharacterized property of natural human adenovirus infection to dictate, modulate and/or alter the course of HCV infection upon exposure.
Tue Jul 19 00:00:00 EDT 2016
A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR.
PloS one
Arellano B,Hussain R,Miller-Little WA,Herndon E,Lambracht-Washington D,Eagar TN,Lewis R,Healey D,Vernino S,Greenberg BM,Stüve O
25-0031 was used in Flow cytometry/Cell sorting to reveal that a single amino acid substitution in aquaporin 4 prevents its recognition by the murine T cell receptor.
Mon Aug 22 00:00:00 EDT 2016
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Oncotarget
Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG
25-0031 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.
Tue Dec 13 00:00:00 EST 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
25-0031-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response.
Scientific reports
González-Hernández A,Van Coppernolle S,Borloo J,Van Meulder F,Paerewijck O,Peelaers I,Leclercq G,Claerebout E,Geldhof P
25-0031 was used in Flow cytometry/Cell sorting to elucidate the immunological importance of both the antigen and adjuvant: nASP and QuilA respectively, in a Ostertagia ostertagi vaccine.
Mon Jul 11 00:00:00 EDT 2016
A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.
JCI insight
Srivastava N,Iyer S,Sudan R,Youngs C,Engelman RW,Howard KT,Russo CM,Chisholm JD,Kerr WG
25-0031 was used in Flow cytometry/Cell sorting to investigate how SHIPi represents an approach that permits control of obesity and diet-induced metabolic syndrome without apparent toxicity.
Thu Jul 21 00:00:00 EDT 2016
Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.
PloS one
Uhde AK,Herder V,Akram Khan M,Ciurkiewicz M,Schaudien D,Teich R,Floess S,Baumgärtner W,Huehn J,Beineke A
25003182 was used in flow cytometry to study the effect of IL-10 signaling in infectious neurological diseases
Fri Aug 25 00:00:00 EDT 2017
Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.
Respiratory research
Baker K,Raemdonck K,Dekkak B,Snelgrove RJ,Ford J,Shala F,Belvisi MG,Birrell MA
25-0031 was used in Flow cytometry/Cell sorting to study the role of TRPV1 in rodent models of asthma, showing that TRPV1 KO or pharmacological inhibition of TRPV1 leads to decreased symptoms, suggesting it may be a target for further investigation.
Thu Jun 02 00:00:00 EDT 2016
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Nature communications
Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA
25-0031 was used in Flow cytometry/Cell sorting to study how androgen levels protects against autoimmunity, and exploring the sex bias to androgen protection from T-cell-mediated autoimmune diseases.
Wed Apr 13 00:00:00 EDT 2016
Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.
Nature medicine
Chimen M,McGettrick HM,Apta B,Kuravi SJ,Yates CM,Kennedy A,Odedra A,Alassiri M,Harrison M,Martin A,Barone F,Nayar S,Hitchcock JR,Cunningham AF,Raza K,Filer A,Copland DA,Dick AD,Robinson J,Kalia N,Walker LSK,Buckley CD,Nash GB,Narendran P,Rainger GE
25-0031 was used in Flow cytometry/Cell sorting to demonstrate that exogenous PEPITEM reduces T cell recruitment into inflamed tissues in multiple animal models of autoimmune, inflammatory diseases.
Fri May 01 00:00:00 EDT 2015
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
25003182 was used in flow cytometry to investigate the application of intra-dermal mesoporous silica rods in immune modulation.
Thu Jan 01 00:00:00 EST 2015
Early virus-host interactions dictate the course of a persistent infection.
PLoS pathogens
Sullivan BM,Teijaro JR,de la Torre JC,Oldstone MB
25-0031 was used in Flow cytometry/Cell sorting to investigate the very early host-virus interactions that determine the establishment of viral persistence.
Thu Jan 01 00:00:00 EST 2015
IκBNS regulates murine Th17 differentiation during gut inflammation and infection.
Journal of immunology (Baltimore, Md. : 1950)
Annemann M,Wang Z,Plaza-Sirvent C,Glauben R,Schuster M,Ewald Sander F,Mamareli P,Kühl AA,Siegmund B,Lochner M,Schmitz I
25-0031 was used in Flow cytometry/Cell sorting to study the role of nuclear IκBNS in murine Th17 cell generation upon inflammation and infection.
Sun Mar 15 00:00:00 EDT 2015
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
25-0031 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.
Wed Aug 12 00:00:00 EDT 2015
ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms.
Nature communications
Bouchery T,Kyle R,Camberis M,Shepherd A,Filbey K,Smith A,Harvie M,Painter G,Johnston K,Ferguson P,Jain R,Roediger B,Delahunt B,Weninger W,Forbes-Blom E,Le Gros G
25003182 was used in flow cytometry to show that CD4 positive T cells and ILC2s together block Nippostrongylus brasiliensis development in the parenchyma
Mon Apr 27 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
25-0031 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.
PloS one
O'Flaherty BM,Matar CG,Wakeman BS,Garcia A,Wilke CA,Courtney CL,Moore BB,Speck SH
25-0031 was used in Flow cytometry/Cell sorting to investigate the role that the MHV68 gene plays in the development of pulmonary fibrosis.
Thu Jun 09 00:00:00 EDT 2016
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
Scientific reports
Goritzka M,Pereira C,Makris S,Durant LR,Johansson C
25-0031 was used in Flow cytometry/Cell sorting to highlight an unappreciated level of redundancy in pathways that couple innate virus sensing to adaptive immunity.
Mon Dec 21 00:00:00 EST 2015
An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment.
Blood
Gibbins JD,Ancelet LR,Weinkove R,Compton BJ,Painter GF,Petersen TR,Hermans IF
25-0031 was used in Flow cytometry/Cell sorting to investigate the efficacy of an intravenously administered vaccine consisting of irradiated leukemia cells loaded with α-GalCer.
Thu Nov 06 00:00:00 EST 2014
Endothelial C-type natriuretic peptide maintains vascular homeostasis.
The Journal of clinical investigation
Moyes AJ,Khambata RS,Villar I,Bubb KJ,Baliga RS,Lumsden NG,Xiao F,Gane PJ,Rebstock AS,Worthington RJ,Simone MI,Mota F,Rivilla F,Vallejo S,Peiró C,Sánchez Ferrer CF,Djordjevic S,Caulfield MJ,MacAllister RJ,Selwood DL,Ahluwalia A,Hobbs AJ
25-0031 was used in Flow cytometry/Cell sorting to evaluate mice with endothelial-specific deletion of C-type natriuretic peptide (CNP), showing that it is essential for multiple aspects of vascular regulation.
Mon Sep 01 00:00:00 EDT 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
25-0031 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.
Tue Apr 15 00:00:00 EDT 2014
The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.
Journal of immunology (Baltimore, Md. : 1950)
Ni PP,Solomon B,Hsieh CS,Allen PM,Morris GP
25-0031 was used in Flow cytometry/Cell sorting to investigate how dual TCR rearrangements enhance positive selection and alter allo- and autoreactive T cell repertoires.
Fri Aug 15 00:00:00 EDT 2014
CD40 ligand preferentially modulates immune response and enhances protection against influenza virus.
Journal of immunology (Baltimore, Md. : 1950)
Hashem AM,Gravel C,Chen Z,Yi Y,Tocchi M,Jaentschke B,Fan X,Li C,Rosu-Myles M,Pereboev A,He R,Wang J,Li X
25-0031 was used in Flow cytometry/Cell sorting to characterise an increased in vivo load of CD40-targeted Ag upon the secretion of the NP-CD40L fusion protein from adenovirus-infected cells.
Tue Jul 15 00:00:00 EDT 2014
rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study.
Gene therapy
Rocca CJ,Ur SN,Harrison F,Cherqui S
25-0031 was used in Immunofluorescence to report an optimised kidney-targeted gene delivery strategy using recombinant adeno-associated virus administered via retrograde renal vein injection in mice.
Sun Jun 01 00:00:00 EDT 2014
The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector.
BioMed research international
Hemmi M,Tachibana M,Tsuzuki S,Shoji M,Sakurai F,Kawabata K,Kobiyama K,Ishii KJ,Akira S,Mizuguchi H
25-0031 was used in Flow cytometry/Cell sorting to suggest that type I IFN signaling has an important role in the translation of systemic innate immune response into mucosal adaptive immunity by amplifying the innate immune signaling and activating CTLs in the iLN.
Mon May 02 00:00:00 EDT 2016
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Journal of neuroimmunology
Dey M,Chang AL,Wainwright DA,Ahmed AU,Han Y,Balyasnikova IV,Lesniak MS
25-0031 was used in Flow cytometry/Cell sorting to assess the benefit of higher HO1 expression in Tregs in glioma.
Wed Jan 15 00:00:00 EST 2014
Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.
Journal of inflammation research
Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC
25-0031 was used in Flow cytometry/Cell sorting to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.
Thu Mar 27 00:00:00 EDT 2014
Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome.
Molecular therapy. Methods & clinical development
Shimizu K,Sakurai F,Tomita K,Nagamoto Y,Nakamura S,Katayama K,Tachibana M,Kawabata K,Mizuguchi H
25-0031 was used in Flow cytometry/Cell sorting to investigate how insertion of microRNA-targeted sequences into replication-incompetent adenovirus vector genomes can suppress leaky expression of adenoviral genes.
Wed May 27 00:00:00 EDT 2015
Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis.
PloS one
Weitkamp JH,Rosen MJ,Zhao Z,Koyama T,Geem D,Denning TL,Rock MT,Moore DJ,Halpern MD,Matta P,Denning PW
25-0031 was used in Flow cytometry/Cell sorting to study the development of γδ intraepithelial lymphocytes in the ileum of human infants and examine their role in pathogenesis of necrotizing enterocolitis.
Tue Oct 06 00:00:00 EDT 2015
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Goto R,You S,Zaitsu M,Chatenoud L,Wood KJ
25-0031 was used in Flow cytometry/Cell sorting to investigate the result of delayed anti-CD3 therapy on the number and dominance of alloreactive/graft infiltrating cells.
Mon Jul 01 00:00:00 EDT 2013
CD22 is required for protection against West Nile virus Infection.
Journal of virology
Ma DY,Suthar MS,Kasahara S,Gale M,Clark EA
25-0031 was used in Flow cytometry/Cell sorting to elucidate the immunological requirements for an antibody response following West Nile virus infection.
Fri Mar 01 00:00:00 EST 2013
Differential expression of the Ly49G(B6), but not the Ly49G(BALB), receptor isoform during natural killer cell reconstitution after hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Barao I,Wright PW,Sungur CM,Anderson SK,Redelman D,Murphy WJ
25-0031 was used in Flow cytometry/Cell sorting to evaluate the expression of two isoforms of the inhibitory NK cell receptor, Ly49G, in CB6F1 mice following hematopoietic stem cell transplantation.
Tue Oct 01 00:00:00 EDT 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
25-0031 was used in Flow cytometry/Cell sorting to identify a unique function for gV-sPLA2 in the activation and recruitment of immune cells.
Sat Jun 15 00:00:00 EDT 2013
Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Bassity E,Flies A,Strutt TM,Garcia-Hernandez Mde L,McKinstry KK,Zou T,Swain SL,Dutton RW
25-0031 was used in Flow cytometry/Cell sorting to define the mechanisms by which Tc1 or Tc17 CD8 effectors confer protection against influenza infection.
Tue Jan 01 00:00:00 EST 2013
CD11b+GR1+ myeloid cells secrete NGF and promote trigeminal ganglion neurite growth: implications for corneal nerve regeneration.
Investigative ophthalmology & visual science
Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S
25-0031 was used in Flow cytometry/Cell sorting to study trigeminal ganglion neurites using mice with fluorescent bone marrow cells to show increased growth when CD11b+GR1+ myeloid cells secrete NGF.
Tue Sep 03 00:00:00 EDT 2013
Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant.
Immunobiology
Engel AL,Sun GC,Gad E,Rastetter LR,Strobe K,Yang Y,Dang Y,Disis ML,Lu H
25-0031 was used in an ELISpot assay to evaluate the effect of protein-bound polysaccharide-K on dendritic cell activation and its potential as a vaccine adjuvant.
Sun Dec 01 00:00:00 EST 2013
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Cellular & molecular immunology
Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L
25-0031 was used in Flow cytometry/Cell sorting to provide a novel understanding of the interaction between iTregs and DCs, and its role in iTreg-mediated immune suppression.
Thu Mar 01 00:00:00 EST 2012
IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.
PLoS pathogens
Owens BM,Beattie L,Moore JW,Brown N,Mann JL,Dalton JE,Maroof A,Kaye PM
25-0031 was used in Flow cytometry/Cell sorting to demonstrate that only CD11c(hi) dendritic cells that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo.
Tue Jan 29 00:00:00 EST 2013
Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.
Journal of leukocyte biology
Dickgreber N,Farrand KJ,van Panhuys N,Knight DA,McKee SJ,Chong ML,Miranda-Hernandez S,Baxter AG,Locksley RM,Le Gros G,Hermans IF
25-0031 was used in Flow cytometry/Cell sorting to investigate the regulated pattern of IL-4 expression by maturing NKT cells, which may endow these cells with a capacity to influence the development of surrounding cells in the thymus.
Thu Nov 01 00:00:00 EDT 2012
Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.
PloS one
Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M
25-0031 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.
Tue Jun 11 00:00:00 EDT 2013
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.
Cell
Teijaro JR,Walsh KB,Cahalan S,Fremgen DM,Roberts E,Scott F,Martinborough E,Peach R,Oldstone MB,Rosen H
25-0031 was used in Flow cytometry/Cell sorting to elucidate cellular and signalling mechanisms that are important in initiating cytokine storm.
Fri Sep 16 00:00:00 EDT 2011
Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC.
Blood
Barao I,Alvarez M,Ames E,Orr MT,Stefanski HE,Blazar BR,Lanier LL,Anderson SK,Redelman D,Murphy WJ
25-0031 was used in Flow cytometry/Cell sorting to show that during reconstitution after HSCT and various activation stimuli, preferential expansion of the Ly49G2 receptor on NK cells occurs independently of MHC haplotype.
Thu Jun 30 00:00:00 EDT 2011
Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.
Blood
Taveirne S,Filtjens J,Van Ammel E,De Colvenaer V,Kerre T,Taghon T,Vandekerckhove B,Plum J,Held W,Leclercq G
25-0031 was used in Functional assays to assess whether inhibitory MHC-I receptors educate only natural killer cells or whether they evoke responses in all cell types, which express them.
Thu Jul 14 00:00:00 EDT 2011
Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Barao I,Alvarez M,Redelman D,Weiss JM,Ortaldo JR,Wiltrout RH,Murphy WJ
25-0031 was used in Flow cytometry/Cell sorting to highlight cytokine gene transfer-based methods as a potential platform for natural killer cell recovery after bone marrow transplantation in mice.
Thu Dec 01 00:00:00 EST 2011
CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.
International immunology
Ebisawa M,Hase K,Takahashi D,Kitamura H,Knoop KA,Williams IR,Ohno H
25-0031 was used in Flow cytometry/Cell sorting to suggest that the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation.
Fri Apr 01 00:00:00 EDT 2011
The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.
Parasite immunology
Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L
25-0031 was used in Flow cytometry/Cell sorting to investigate TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells, showing that the magnitude of activation rather than TCR diversity determines the outcome of infection.
Tue Mar 01 00:00:00 EST 2011
Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma.
Journal of immunology (Baltimore, Md. : 1950)
Anraku M,Tagawa T,Wu L,Yun Z,Keshavjee S,Zhang L,Johnston MR,de Perrot M
25-0031 was used in Flow cytometry/Cell sorting to evaluate the potential of a combined Treg blockade-permetrexed anti-tumour treatment.
Thu Jul 15 00:00:00 EDT 2010
Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.
PloS one
de Souza JB,Okomo U,Alexander ND,Aziz N,Owens BM,Kaur H,Jasseh M,Muangnoicharoen S,Sumariwalla PF,Warhurst DC,Ward SA,Conway DJ,Ulloa L,Tracey KJ,Foxwell BM,Kaye PM,Walther M
25-0031 was used in Flow cytometry/Cell sorting to find that oAC provided significant protection against P. berghei ANKA-induced ECM, increasing overall survival time compared to untreated mice.
Thu Apr 15 00:00:00 EDT 2010
Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.
American journal of respiratory cell and molecular biology
Hoshino T,Okamoto M,Sakazaki Y,Kato S,Young HA,Aizawa H
25-0031 was used in Flow cytometry/Cell sorting to elucidate the role of proinflammatory cytokines in chemotherapeutic drug-induced lung injury.
Tue Dec 01 00:00:00 EST 2009
Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.
Journal of leukocyte biology
Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D
25-0031 was used in Flow cytometry/Cell sorting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..
Tue Sep 01 00:00:00 EDT 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
25-0031 was used in Flow cytometry/Cell sorting to study the role of Tc17 cells in influenza infection, showing that they protect against lethality.
Sun Mar 15 00:00:00 EDT 2009
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Astrakhan A,Ochs HD,Rawlings DJ
25-0031 was used in Flow cytometry/Cell sorting to investigate the role for WASp within the iNKT lineage.
Mon Jun 15 00:00:00 EDT 2009
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
International journal of cancer
Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH
Thu Jun 01 00:00:00 EDT 2006
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infection and immunity
Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG
25-0031 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.
Wed Nov 01 00:00:00 EST 2006
Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Krieg C,Han P,Stone R,Goularte OD,Kaye J
Tue Nov 15 00:00:00 EST 2005
CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.
Investigative ophthalmology & visual science
Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M
Sat Oct 01 00:00:00 EDT 2005
